Hepatocellular carcinoma metastatic to skin: diagnostic utility of antihuman hepatocyte antibody in combination with albumin in situ hybridization

Background:  Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated, hindering accurate diagnosis on routine examination by hematoxylin‐eosin stain. Antihuman hepatocyte antibody is highly sensitive for HCC but can...

Full description

Saved in:
Bibliographic Details
Published inJournal of cutaneous pathology Vol. 36; no. 2; pp. 262 - 266
Main Authors Wood, Angela J., Lappinga, Paul J., Ahmed, Iftikhar
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.02.2009
Wiley-Blackwell
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Background:  Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated, hindering accurate diagnosis on routine examination by hematoxylin‐eosin stain. Antihuman hepatocyte antibody is highly sensitive for HCC but can be strongly expressed in other adenocarcinomas. Albumin in situ hybridization (ISH) is highly specific and sensitive for HCC; in combination with antihuman hepatocyte antibody, it has a diagnostic sensitivity approaching 100%. To our knowledge, the combination of antihuman hepatocyte antibody and albumin ISH has not previously been examined in the context of cutaneous HCC. Methods:  We present histologic findings and results of ancillary studies for three patients with metastatic HCC. These patients had a poorly differentiated cytokeratin‐positive cutaneous neoplasm. All three cases were evaluated with antihuman hepatocyte antibody and albumin ISH. Results:  Neoplastic cells were strongly positive for antihuman hepatocyte antibody, and ISH detected albumin messenger RNA in nearly 100% of the neoplastic cells in all three cases. Conclusions:  The combination of antihuman hepatocyte antibody and albumin ISH is highly sensitive and specific for HCC metastatic to skin and is useful in the differential diagnosis of a poorly differentiated cytokeratin‐positive neoplasm.
AbstractList Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated, hindering accurate diagnosis on routine examination by hematoxylin-eosin stain. Antihuman hepatocyte antibody is highly sensitive for HCC but can be strongly expressed in other adenocarcinomas. Albumin in situ hybridization (ISH) is highly specific and sensitive for HCC; in combination with antihuman hepatocyte antibody, it has a diagnostic sensitivity approaching 100%. To our knowledge, the combination of antihuman hepatocyte antibody and albumin ISH has not previously been examined in the context of cutaneous HCC. We present histologic findings and results of ancillary studies for three patients with metastatic HCC. These patients had a poorly differentiated cytokeratin-positive cutaneous neoplasm. All three cases were evaluated with antihuman hepatocyte antibody and albumin ISH. Neoplastic cells were strongly positive for antihuman hepatocyte antibody, and ISH detected albumin messenger RNA in nearly 100% of the neoplastic cells in all three cases. The combination of antihuman hepatocyte antibody and albumin ISH is highly sensitive and specific for HCC metastatic to skin and is useful in the differential diagnosis of a poorly differentiated cytokeratin-positive neoplasm.
Background:Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated, hindering accurate diagnosis on routine examination by hematoxylin-eosin stain. Antihuman hepatocyte antibody is highly sensitive for HCC but can be strongly expressed in other adenocarcinomas. Albumin in situ hybridization (ISH) is highly specific and sensitive for HCC; in combination with antihuman hepatocyte antibody, it has a diagnostic sensitivity approaching 100%. To our knowledge, the combination of antihuman hepatocyte antibody and albumin ISH has not previously been examined in the context of cutaneous HCC.Methods:We present histologic findings and results of ancillary studies for three patients with metastatic HCC. These patients had a poorly differentiated cytokeratin-positive cutaneous neoplasm. All three cases were evaluated with antihuman hepatocyte antibody and albumin ISH.Results:Neoplastic cells were strongly positive for antihuman hepatocyte antibody, and ISH detected albumin messenger RNA in nearly 100% of the neoplastic cells in all three cases.Conclusions:The combination of antihuman hepatocyte antibody and albumin ISH is highly sensitive and specific for HCC metastatic to skin and is useful in the differential diagnosis of a poorly differentiated cytokeratin-positive neoplasm.Wood AJ, Lappinga PJ, Ahmed I. Hepatocellular carcinoma metastatic to skin: diagnostic utility of antihuman hepatocyte antibody in combination with albumin in situ hybridization. J Cutan Pathol 2009; 36: 262-266. [copy 2008 Blackwell Munksgaard.
Background:  Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated, hindering accurate diagnosis on routine examination by hematoxylin‐eosin stain. Antihuman hepatocyte antibody is highly sensitive for HCC but can be strongly expressed in other adenocarcinomas. Albumin in situ hybridization (ISH) is highly specific and sensitive for HCC; in combination with antihuman hepatocyte antibody, it has a diagnostic sensitivity approaching 100%. To our knowledge, the combination of antihuman hepatocyte antibody and albumin ISH has not previously been examined in the context of cutaneous HCC. Methods:  We present histologic findings and results of ancillary studies for three patients with metastatic HCC. These patients had a poorly differentiated cytokeratin‐positive cutaneous neoplasm. All three cases were evaluated with antihuman hepatocyte antibody and albumin ISH. Results:  Neoplastic cells were strongly positive for antihuman hepatocyte antibody, and ISH detected albumin messenger RNA in nearly 100% of the neoplastic cells in all three cases. Conclusions:  The combination of antihuman hepatocyte antibody and albumin ISH is highly sensitive and specific for HCC metastatic to skin and is useful in the differential diagnosis of a poorly differentiated cytokeratin‐positive neoplasm.
BACKGROUNDCutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated, hindering accurate diagnosis on routine examination by hematoxylin-eosin stain. Antihuman hepatocyte antibody is highly sensitive for HCC but can be strongly expressed in other adenocarcinomas. Albumin in situ hybridization (ISH) is highly specific and sensitive for HCC; in combination with antihuman hepatocyte antibody, it has a diagnostic sensitivity approaching 100%. To our knowledge, the combination of antihuman hepatocyte antibody and albumin ISH has not previously been examined in the context of cutaneous HCC.METHODSWe present histologic findings and results of ancillary studies for three patients with metastatic HCC. These patients had a poorly differentiated cytokeratin-positive cutaneous neoplasm. All three cases were evaluated with antihuman hepatocyte antibody and albumin ISH.RESULTSNeoplastic cells were strongly positive for antihuman hepatocyte antibody, and ISH detected albumin messenger RNA in nearly 100% of the neoplastic cells in all three cases.CONCLUSIONSThe combination of antihuman hepatocyte antibody and albumin ISH is highly sensitive and specific for HCC metastatic to skin and is useful in the differential diagnosis of a poorly differentiated cytokeratin-positive neoplasm.
Background:  Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated, hindering accurate diagnosis on routine examination by hematoxylin‐eosin stain. Antihuman hepatocyte antibody is highly sensitive for HCC but can be strongly expressed in other adenocarcinomas. Albumin in situ hybridization (ISH) is highly specific and sensitive for HCC; in combination with antihuman hepatocyte antibody, it has a diagnostic sensitivity approaching 100%. To our knowledge, the combination of antihuman hepatocyte antibody and albumin ISH has not previously been examined in the context of cutaneous HCC. Methods:  We present histologic findings and results of ancillary studies for three patients with metastatic HCC. These patients had a poorly differentiated cytokeratin‐positive cutaneous neoplasm. All three cases were evaluated with antihuman hepatocyte antibody and albumin ISH. Results:  Neoplastic cells were strongly positive for antihuman hepatocyte antibody, and ISH detected albumin messenger RNA in nearly 100% of the neoplastic cells in all three cases. Conclusions:  The combination of antihuman hepatocyte antibody and albumin ISH is highly sensitive and specific for HCC metastatic to skin and is useful in the differential diagnosis of a poorly differentiated cytokeratin‐positive neoplasm.
Author Ahmed, Iftikhar
Lappinga, Paul J.
Wood, Angela J.
Author_xml – sequence: 1
  givenname: Angela J.
  surname: Wood
  fullname: Wood, Angela J.
– sequence: 2
  givenname: Paul J.
  surname: Lappinga
  fullname: Lappinga, Paul J.
– sequence: 3
  givenname: Iftikhar
  surname: Ahmed
  fullname: Ahmed, Iftikhar
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21046805$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/18727662$$D View this record in MEDLINE/PubMed
BookMark eNqNkc1u1DAQgC1URLeFV0C-wC3BduKfIHFAK6BIleBAz5Z_WS-JvcSO2vAYPDHJ7qocwbJka-absTXfFbiIKToAIEY1XtabfY0ZQhWiDNUEIVEjjEhXPzwBm8fEBdigBjUV6wS_BFc57xHCTDD6DFxiwQlnjGzA7xt3UCUZ1_dTr0Zo1GhCTIOCgysqF1WCgSXB_CPEt9AG9T2mvMamEvpQZpg8VLGE3TSoCHenZnNxx6BOdoYhQpMGHeLSKkV4H8oOql5Pw5JYdg5lgrtZj8GGX0fkOXjqVZ_di_N5De4-fvi2valuv3z6vH1_W5mWiK6yxFqvdYs9t60njfFtywnB1FomuNKWLyPpPOHacIEE81ZpalsqEMZccd1cg9envocx_ZxcLnIIeR2Eii5NWTLWYcqa5p8gQU1LCV1BcQLNmHIenZeHMQxqnCVGchUn93L1I1c_chUnj-Lkw1L68vzGpAdn_xaeTS3AqzOgslG9H1U0IT9yBKOWCUQX7t2Juw-9m__7A3J793W9NX8ArSe5jw
CODEN JCUPBN
CitedBy_id crossref_primary_10_1111_j_1365_4632_2011_05001_x
crossref_primary_10_3342_kjorl_hns_2016_16159
crossref_primary_10_1007_s12663_011_0187_z
crossref_primary_10_1016_j_ad_2011_06_010
crossref_primary_10_3348_jksr_2012_67_4_285
crossref_primary_10_1002_hep_29615
crossref_primary_10_1007_s00432_022_04030_0
crossref_primary_10_1002_jgh3_12743
crossref_primary_10_1097_MNM_0000000000001380
crossref_primary_10_1097_DAD_0b013e31823069cf
crossref_primary_10_1097_CM9_0000000000000083
crossref_primary_10_4166_kjg_2020_75_6_362
crossref_primary_10_1016_j_adengl_2012_05_014
Cites_doi 10.1097/00000478-199702000-00003
10.1046/j.1365-4362.2001.01319.x
10.1007/s00534-006-1141-1
10.1046/j.1365-2230.1999.00423.x
10.1309/8L872RPHEJRKF5JJ
10.1007/s10620-006-9465-x
10.1111/j.1478-3231.2006.01399.x
10.1309/1GUHU5LK2A82JTJR
10.1034/j.1600-0560.2003.00128.x
10.1159/000325720
ContentType Journal Article
Copyright 2008 Blackwell Munksgaard
2009 INIST-CNRS
Copyright_xml – notice: 2008 Blackwell Munksgaard
– notice: 2009 INIST-CNRS
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QO
8FD
FR3
P64
7X8
DOI 10.1111/j.1600-0560.2008.01029.x
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Biotechnology Research Abstracts
Technology Research Database
Engineering Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Engineering Research Database
Biotechnology Research Abstracts
Technology Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitleList MEDLINE
Engineering Research Database

MEDLINE - Academic
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1600-0560
EndPage 266
ExternalDocumentID 10_1111_j_1600_0560_2008_01029_x
18727662
21046805
CUP1029
Genre caseStudy
Journal Article
Case Reports
GroupedDBID ---
.3N
.GA
.GJ
.Y3
05W
0R~
10A
1OB
1OC
29K
31~
33P
36B
3O-
3SF
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5GY
5HH
5LA
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAESR
AAEVG
AAHHS
AAKAS
AANLZ
AAONW
AAQQT
AASGY
AAXRX
AAZKR
ABCQN
ABCUV
ABDBF
ABEML
ABJNI
ABPVW
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFS
ACGOF
ACMXC
ACPOU
ACPRK
ACSCC
ACXBN
ACXQS
ADBBV
ADBTR
ADEOM
ADIZJ
ADKYN
ADMGS
ADOZA
ADXAS
ADZCM
ADZMN
AEEZP
AEIGN
AEIMD
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFEBI
AFFNX
AFFPM
AFGKR
AFPWT
AFZJQ
AHBTC
AHEFC
AIACR
AITYG
AIURR
AIWBW
AJBDE
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMBMR
AMYDB
ASPBG
ATUGU
AVWKF
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BY8
C45
CAG
COF
CS3
CYRXZ
D-6
D-7
D-E
D-F
D-I
DC6
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
DU5
EAD
EAP
EBC
EBD
EBS
EJD
EMB
EMK
EMOBN
ESX
EX3
F00
F01
F04
F5P
FEDTE
FUBAC
FZ0
G-S
G.N
GODZA
H.X
HF~
HGLYW
HVGLF
HZI
HZ~
IHE
IX1
J0M
K48
KBYEO
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
MEWTI
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
O66
O9-
OIG
OVD
P2P
P2W
P2X
P2Z
P4B
P4D
PALCI
Q.N
Q11
QB0
R.K
RIWAO
RJQFR
ROL
RX1
SAMSI
SUPJJ
SV3
TEORI
TUS
UB1
W8V
W99
WBKPD
WHWMO
WIH
WIJ
WIK
WOHZO
WOW
WQJ
WRC
WUP
WVDHM
WXI
WXSBR
XG1
YFH
ZGI
ZXP
ZZTAW
~IA
~WT
AAVGM
ABHUG
ABPTK
ACXME
ADAWD
ADDAD
AFVGU
AGJLS
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QO
8FD
FR3
P64
7X8
ID FETCH-LOGICAL-c4289-d2ddfbb41f7d4f23cf4472215dd687abd70299f27bc78086fdab5d4580117a7b3
IEDL.DBID DR2
ISSN 0303-6987
IngestDate Fri Aug 16 08:13:34 EDT 2024
Sat Aug 17 01:56:58 EDT 2024
Fri Aug 23 02:55:42 EDT 2024
Sat Sep 28 07:50:31 EDT 2024
Sun Oct 22 16:10:10 EDT 2023
Sat Aug 24 01:03:20 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords Drug combination
Antibody
Dermatology
In situ
Albumin
Hepatic disease
Hepatocellular carcinoma
Malignant tumor
Hybridization
Metastasis
Anatomic pathology
Hepatocyte
Digestive diseases
Metastatic
Skin
Diagnosis
Cancer
Language English
License CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4289-d2ddfbb41f7d4f23cf4472215dd687abd70299f27bc78086fdab5d4580117a7b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Case Study-2
ObjectType-Feature-4
ObjectType-Report-1
ObjectType-Article-3
PMID 18727662
PQID 20345253
PQPubID 23462
PageCount 5
ParticipantIDs proquest_miscellaneous_66915633
proquest_miscellaneous_20345253
crossref_primary_10_1111_j_1600_0560_2008_01029_x
pubmed_primary_18727662
pascalfrancis_primary_21046805
wiley_primary_10_1111_j_1600_0560_2008_01029_x_CUP1029
PublicationCentury 2000
PublicationDate February 2009
PublicationDateYYYYMMDD 2009-02-01
PublicationDate_xml – month: 02
  year: 2009
  text: February 2009
PublicationDecade 2000
PublicationPlace Oxford, UK
PublicationPlace_xml – name: Oxford, UK
– name: Malden, MA
– name: United States
PublicationTitle Journal of cutaneous pathology
PublicationTitleAlternate J Cutan Pathol
PublicationYear 2009
Publisher Blackwell Publishing Ltd
Wiley-Blackwell
Publisher_xml – name: Blackwell Publishing Ltd
– name: Wiley-Blackwell
References 2004; 122
2003; 119
1997; 44
1997; 21
2006; 35
2004; 25
1999; 24
2007; 51
2007; 52
2003; 30
2001; 40
2007; 14
2001; 64
2007; 27
e_1_2_5_14_2
e_1_2_5_13_2
e_1_2_5_9_2
Okusaka T (e_1_2_5_8_2) 1997; 44
Al‐Mashat FM (e_1_2_5_12_2) 2004; 25
e_1_2_5_7_2
e_1_2_5_10_2
e_1_2_5_6_2
e_1_2_5_5_2
e_1_2_5_4_2
e_1_2_5_11_2
e_1_2_5_2_2
Nggada HA (e_1_2_5_15_2) 2006; 35
Fang YR (e_1_2_5_3_2) 2001; 64
References_xml – volume: 21
  start-page: 147
  year: 1997
  article-title: Detection of albumin messenger RNA in hepatic and extrahepatic neoplasms: a marker of hepatocellular differentiation
  publication-title: Am J Surg Pathol
– volume: 24
  start-page: 78
  year: 1999
  article-title: Cutaneous metastasis from hepatocellular carcinoma resembling pyogenic granuloma
  publication-title: Clin Exp Dermatol
– volume: 119
  start-page: 361
  year: 2003
  article-title: Immunoreactivity of Hep Par 1 in hepatic and extrahepatic tumors and its correlation with albumin in situ hybridization in hepatocellular carcinoma
  publication-title: Am J Clin Pathol
– volume: 35
  start-page: 181
  year: 2006
  article-title: Cutaneous metastasis from hepatocellular carcinoma: a rare presentation and review of the literature
  publication-title: Afr J Med Med Sci
– volume: 122
  start-page: 85
  year: 2004
  article-title: Immunoreactivity of hepatocyte paraffin 1 monoclonal antibody in cutaneous metastatic tumors
  publication-title: Am J Clin Pathol
– volume: 44
  start-page: 251
  year: 1997
  article-title: Prognosis of hepatocellular carcinoma patients with extrahepatic metastases
  publication-title: Hepatogastroenterology
– volume: 25
  start-page: 370
  year: 2004
  article-title: Hepatocellular carcinoma with cutaneous metastasis
  publication-title: Saudi Med J
– volume: 64
  start-page: 253
  year: 2001
  article-title: An unusual cutaneous metastasis from hepatocellular carcinoma
  publication-title: Zhonghua Yi Xue Za Zhi (Taipei)
– volume: 51
  start-page: 214
  year: 2007
  article-title: Cutaneous metastasis of occult hepatocellular carcinoma: a case report
  publication-title: Acta Cytol
– volume: 40
  start-page: 782
  year: 2001
  article-title: Cutaneous metastases from hepatocellular carcinoma
  publication-title: Int J Dermatol
– volume: 52
  start-page: 1114
  year: 2007
  article-title: Cutaneous and colonic metastases after resection of hepatocellular carcinoma
  publication-title: Dig Dis Sci
– volume: 14
  start-page: 328
  year: 2007
  article-title: Cutaneous metastasis from hepatocellular carcinoma as the first clinical sign
  publication-title: J Hepatobiliary Pancreat Surg
– volume: 30
  start-page: 637
  year: 2003
  article-title: Cutaneous metastasis of hepatocellular carcinoma diagnosed with hepatocyte paraffin (Hep Par 1) antibody immunohistochemistry
  publication-title: J Cutan Pathol
– volume: 27
  start-page: 192
  year: 2007
  article-title: Incidence of needle tract seeding and responses of soft tissue metastasis by hepatocellular carcinoma postradiotherapy
  publication-title: Liver Int
– ident: e_1_2_5_2_2
  doi: 10.1097/00000478-199702000-00003
– ident: e_1_2_5_10_2
  doi: 10.1046/j.1365-4362.2001.01319.x
– ident: e_1_2_5_6_2
  doi: 10.1007/s00534-006-1141-1
– ident: e_1_2_5_11_2
  doi: 10.1046/j.1365-2230.1999.00423.x
– ident: e_1_2_5_13_2
  doi: 10.1309/8L872RPHEJRKF5JJ
– ident: e_1_2_5_5_2
  doi: 10.1007/s10620-006-9465-x
– volume: 44
  start-page: 251
  year: 1997
  ident: e_1_2_5_8_2
  article-title: Prognosis of hepatocellular carcinoma patients with extrahepatic metastases
  publication-title: Hepatogastroenterology
  contributor:
    fullname: Okusaka T
– ident: e_1_2_5_9_2
  doi: 10.1111/j.1478-3231.2006.01399.x
– volume: 64
  start-page: 253
  year: 2001
  ident: e_1_2_5_3_2
  article-title: An unusual cutaneous metastasis from hepatocellular carcinoma
  publication-title: Zhonghua Yi Xue Za Zhi (Taipei)
  contributor:
    fullname: Fang YR
– volume: 25
  start-page: 370
  year: 2004
  ident: e_1_2_5_12_2
  article-title: Hepatocellular carcinoma with cutaneous metastasis
  publication-title: Saudi Med J
  contributor:
    fullname: Al‐Mashat FM
– volume: 35
  start-page: 181
  year: 2006
  ident: e_1_2_5_15_2
  article-title: Cutaneous metastasis from hepatocellular carcinoma: a rare presentation and review of the literature
  publication-title: Afr J Med Med Sci
  contributor:
    fullname: Nggada HA
– ident: e_1_2_5_4_2
  doi: 10.1309/1GUHU5LK2A82JTJR
– ident: e_1_2_5_14_2
  doi: 10.1034/j.1600-0560.2003.00128.x
– ident: e_1_2_5_7_2
  doi: 10.1159/000325720
SSID ssj0016865
Score 1.9430734
Snippet Background:  Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated,...
Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated, hindering accurate...
Background:  Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated,...
Background:Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated,...
BACKGROUNDCutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated,...
SourceID proquest
crossref
pubmed
pascalfrancis
wiley
SourceType Aggregation Database
Index Database
Publisher
StartPage 262
SubjectTerms Aged
Albumins - biosynthesis
Albumins - immunology
Antibodies, Neoplasm - chemistry
Antibodies, Neoplasm - immunology
Biological and medical sciences
Carcinoma, Hepatocellular - immunology
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Dermatology
Diagnosis, Differential
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hepatocytes - immunology
Hepatocytes - metabolism
Humans
In Situ Hybridization - methods
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Neoplasm Metastasis
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - immunology
RNA, Messenger - biosynthesis
RNA, Neoplasm - biosynthesis
Skin Neoplasms - immunology
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Skin Neoplasms - secondary
Tumors
Title Hepatocellular carcinoma metastatic to skin: diagnostic utility of antihuman hepatocyte antibody in combination with albumin in situ hybridization
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1600-0560.2008.01029.x
https://www.ncbi.nlm.nih.gov/pubmed/18727662
https://search.proquest.com/docview/20345253
https://search.proquest.com/docview/66915633
Volume 36
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlh1IIfabNpmmqQ69eYsuS7NxKHiyFlFK6kJvRk5gldoi9kO3P6C_ujOTd1iGFUAI-LF5ZSKMZz4znmxlCPnHuFVO5SMAWZUmeS5OUmeOJw-bGxmaGp5icfP5VzOb5lwt-MeCfMBcm1ofYfHBDyQjvaxRwpbuxkAvMigaVPUAiQVeWU7QnUyYR3XXyfVNJKhVF6CoJLM0SAX72GNRz70QjTbV9rTogmo_dLu4zR8fWbVBPZy_IYr2xiEpZTJe9npqfd2o-Ps7OX5LngxVLP0e2e0WeuOY1eXo-xOnfkF8z0HJ9i1EBhLlSgx2LmvZK0SvXK0xiqg3tW9ot6uaI2gj3w3sgBugX0NZTOPI6dBCkl3GyVe_CTd3aFa0bCssGtz5wFsXPyTRAreEPuLq6X9LLFaajDYmmO2R-dvrjeJYM3R8SAy5RmdjMWq91nnppc58x43MsbJlya0UhlbYSNl36TGojC3DMvFWa25wXWOVOSc3ekq2mbdwunDTWvJG6YGDOgQF6qHipYZjPSiUNd3pC0vVJV9exyEf1l3MExK6Q2EPLTiR2dTshByOW2DyYYdS8OOQT8nHNIxWILFJcNa5ddjANw2gy-_cIIUrwqxmMeBeZ68-yCjA4hcgmRAQWefB6q-P5N_y1978PvifPYiQNoTz7ZKu_WboPYJD1-iCI2m9ORSlM
link.rule.ids 315,783,787,1378,27937,27938,46307,46731
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9swEBejg20wus-u2Uerh7061JYl2X0b3Uq2NWWMBvpm9ElNV7ssDjT9M_YX905ysnl0MMYgD8GRhXS6y_1O90XIW869YioXCWBRluS5NEmZOZ44bG5sbGZ4isnJ02MxmeWfTvlp3w4Ic2FifYj1hRtKRvi_RgHHC-mhlAtMiwad3cdEgrIsxwAo74L0M5TS91_XtaRSUYS-ksDULBFgaQ_Dem6daaCrHl6qOZDNx34XtwHSIb4NCurwEfm22lqMSzkfLzo9Nte_VX38T3t_TDZ7IEvfRc57Qu645im5N-1d9c_Ijwkouq5FxwBGulKDTYua9kLRC9cpzGOqDe1aOj-vm31qY8QfPgNJQNOAtp7CqdehiSA9i5MtOxce6tYuad1QWDdY9oG5KN4o0xBtDT_AZ153C3q2xIy0Ptf0OZkdfjg5mCR9A4jEgFVUJjaz1mudp17a3GfM-BxrW6bcWlFIpa2ETZc-k9rIAmwzb5XmNucFFrpTUrMtstG0jduGo8ayN1IXDBAdYNA9xUsNw3xWKmm40yOSro66uox1Pqpf7CMgdoXE7rt2IrGrqxHZGfDE-sUMHefFHh-R3RWTVCC1SHHVuHYxh2kYOpTZn0cIUYJpzWDEi8hdP5dVAOYUIhsREXjkr9dbHcy-4LeX__riLrk_OZkeVUcfjz-_Ig-iYw0je16Tje77wr0BfNbpnSB3N85sLWU
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1ba9RAFB6kQhHEeq1btZ0HX7M0mUuSvkl1WS8tRVzoW5grDUuTxc2C68_wF_ecmexqpIKIkIclOxlmzpyT852cGyGvhfCKKS4TwKIs4Tw3SZk5kThsbmxsZkSKycln53I64x8uxWUf_4S5MLE-xPaDG0pGeF-jgC-sHwq5xKxoUNl9SCToynIMePIul8C5CJA-b0tJpbIIbSWBp1kiwdAeRvXcOtNAVd1fqCVQzcd2F7fh0SG8Dfppskfmm53FsJT5eNXpsfn-W9HH_7P1h-RBD2Ppm8h3j8gd1zwmu2e9o_4J-TEFNde16BbAOFdqsGVR014reu06hVlMtaFdS5fzujmhNsb74T2QAzQMaOspnHkdWgjSqzjZunPhpm7tmtYNhWWDXR9Yi-L3ZBpireEPuJZ1t6JXa8xH6zNNn5LZ5N2X02nSt39IDNhEZWIza73WPPW55T5jxnOsbJkKa2WRK21z2HTps1ybvADLzFulheWiwDJ3KtfsGdlp2sY9h5PGoje5LhjgOUCgx0qUGob5rFS5EU6PSLo56WoRq3xUv1hHQOwKid337ERiV99G5HDAEtsHM3SbF8diRI42PFKBzCLFVePa1RKmYehOZn8eIWUJhjWDEfuRuX4uqwDEKWU2IjKwyF-vtzqdXeCvg3998IjsXrydVJ_en398Qe5FrxqG9bwkO93XlXsF4KzTh0HqbgAZdSwU
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hepatocellular+carcinoma+metastatic+to+skin%3A+diagnostic+utility+of+antihuman+hepatocyte+antibody+in+combination+with+albumin+in+situ+hybridization&rft.jtitle=Journal+of+cutaneous+pathology&rft.au=Wood%2C+Angela+J&rft.au=Lappinga%2C+Paul+J&rft.au=Ahmed%2C+Iftikhar&rft.date=2009-02-01&rft.eissn=1600-0560&rft.volume=36&rft.issue=2&rft.spage=262&rft_id=info:doi/10.1111%2Fj.1600-0560.2008.01029.x&rft_id=info%3Apmid%2F18727662&rft.externalDocID=18727662
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0303-6987&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0303-6987&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0303-6987&client=summon