A critical appraisal of the premotor symptoms of Parkinson's disease: Potential usefulness in early diagnosis and design of neuroprotective trials

• Published in: Movement disorders Vol. 26; no. 5; pp. 775 - 783
• Main Author: Lang, Anthony E.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2011
• Subjects: Autonomic Nervous System Diseases - etiology; Behavioral Symptoms - etiology; Clinical Trials as Topic; Cognition Disorders - etiology; Disease Progression; Early Diagnosis; Humans; neuroprotection; non-motor; olfaction; Parkinson Disease - complications; Parkinson Disease - diagnosis; Parkinson Disease - therapy; Parkinson's disease; Predictive Value of Tests; premotor; rapid eye movement behavior disorder; screening; Sensitivity and Specificity; Sleep Wake Disorders - etiology

The neurodegenerative process is well established in Parkinson patients presenting to a physician with early motor signs. There is increasing evidence that a variety of nonmotor features can antedate the typical presentation by many years. As the search for successful disease‐modifying treatment adv...