Gene expression profiling of renal cell carcinoma: a DNA macroarray analysis

• Published in: BJU international Vol. 98; no. 1; pp. 205 - 216
• Main Authors: LOVISOLO, JON A.J., CASATI, BARBARA, CLERICI, LIBERO, MARAFANTE, ERMINIO, BONO, ALDO V., CELATO, NICOLA, SALVADORE, MAURIZIO
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2006; Blackwell
• Subjects: Biological and medical sciences; Carcinoma, Renal Cell - genetics; DNA macroarray; DNA, Neoplasm - analysis; DNA, Neoplasm - genetics; Female; gene expression; Gene Expression Profiling - methods; genomics; Humans; Kidney Neoplasms - genetics; Kidneys; macroarray; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Oligonucleotide Array Sequence Analysis; quantitative real‐time PCR; renal cell carcinoma; Tumors of the urinary system; Kidney disease; Human; Nephrology; Urinary system disease; Carcinoma; macroarray; Malignant tumor; Gene expression; Real time; quantitative real-time PCR; Urology; Gene expression profile; Polymerase chain reaction; renal cell carcinoma; Cancerology; Kidney cancer; Genetics; Grawitz tumor; genomics; Molecular biology; DNA macroarray; Quantitative analysis

OBJECTIVES To examine differences in gene expression levels between renal cell carcinoma (RCC) tissue and ‘normal’ appearing renal tissue using a commercially available DNA macroarray. MATERIALS AND METHODS Tissue was obtained from 47 consecutive radical nephrectomies, 29 of which were eligible. DNA...