Differentiating Antiproliferative and Chemopreventive Modes of Activity for Electron‐Deficient Aryl Isothiocyanates against Human MCF‐7 Cells

• Published in: ChemMedChem Vol. 13; no. 16; pp. 1695 - 1710
• Main Authors: Anderson, Ruthellen H., Lensing, Cody J., Forred, Benjamin J., Amolins, Michael W., Aegerter, Cassandra L., Vitiello, Peter F., Mays, Jared R.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 20.08.2018; Wiley Subscription Services, Inc
• Subjects: Anticancer properties; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antioxidant Response Elements - genetics; Antioxidants; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; antiproliferation; Antiproliferatives; Aromatic compounds; Benzene Derivatives - chemical synthesis; Benzene Derivatives - chemistry; Benzene Derivatives - pharmacology; Bifurcations; Brassica; Breast cancer; Broccoli; Cancer; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemistry, Medicinal; Clinical trials; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gene Expression - drug effects; Humans; isothiocyanates; Isothiocyanates - chemical synthesis; Isothiocyanates - chemistry; Isothiocyanates - pharmacology; Life Sciences & Biomedicine; MCF-7 Cells; Medical research; Metabolites; Molecular Structure; Pharmacology & Pharmacy; Science & Technology; Secondary metabolites; Small Molecule Libraries - chemical synthesis; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology; Structure-Activity Relationship; structure–activity relationships; Sulforaphane; Time dependence; Transcription; PHENETHYL ISOTHIOCYANATE; GLUCOSINOLATE; sulforaphane; antioxidants; isothiocyanates; PREVENTION; IDENTIFICATION; CRUCIFEROUS VEGETABLES; BREAST-CANCER; CARCINOGENESIS; INHIBITION; structure-activity relationships; NRF2; antiproliferation

The consumption of Brassica vegetables provides beneficial effects through organic isothiocyanates (ITCs), products of the enzymatic hydrolysis of glucosinolate secondary metabolites. The ITC l‐sulforaphane (l‐SFN) is the principle agent in broccoli that demonstrates several modes of anticancer acti...