Comprehensive metabolic modulations of sphingolipids are promising severity indicators in COVID‐19

• Published in: The FASEB journal Vol. 38; no. 14; pp. e23827 - n/a
• Main Authors: Uranbileg, Baasanjav, Isago, Hideaki, Nakayama, Hitoshi, Jubishi, Daisuke, Okamoto, Koh, Sakai, Eri, Kubota, Masayuki, Tsutsumi, Takeya, Moriya, Kyoji, Kurano, Makoto
• Format: Journal Article
• Language: English
• Published: United States 31.07.2024
• Subjects: Adult; Aged; Biomarkers - blood; Biomarkers - metabolism; COVID-19 - blood; COVID-19 - metabolism; COVID-19 - virology; COVID‐19; Female; hexosylceramide (HexCer); Humans; lactosylceramide (LacCer); Male; Middle Aged; SARS-CoV-2; Severity of Illness Index; sphingolipid; Sphingolipids - blood; Sphingolipids - metabolism; sphingosine (Sph); Sphingosine - analogs & derivatives; Sphingosine - metabolism; COVID‐19; hexosylceramide (HexCer); sphingolipid; lactosylceramide (LacCer); sphingosine (Sph)

The COVID‐19 pandemic, caused by SARS‐CoV‐2, has had a significant worldwide impact, affecting millions of people. COVID‐19 is characterized by a heterogenous clinical phenotype, potentially involving hyperinflammation and prolonged tissue damage, although the exact underlying mechanisms are yet to...