Renal sympathetic nervous system hyperactivity in early streptozotocin-induced diabetic kidney disease

• Published in: Neurourology and urodynamics Vol. 30; no. 3; pp. 438 - 446
• Main Authors: Salman, Ibrahim M., Ameer, Omar Z., Sattar, Munavvar A., Abdullah, Nor A., Yam, Mun F., Abdullah, Ghassan Z., Abdulkarim, Muthanna F., Khan, Md. Abdul Hye, Johns, Edward J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2011
• Subjects: Analysis of Variance; Animals; Biomarkers - blood; Blood Pressure; Creatinine - blood; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - physiopathology; diabetic kidney disease; Diabetic Nephropathies - blood; Diabetic Nephropathies - etiology; Diabetic Nephropathies - physiopathology; Electric Stimulation; Glomerular Filtration Rate; Kidney - blood supply; Kidney - innervation; Kidney - physiopathology; Male; Rats; Rats, Sprague-Dawley; Renal Circulation; renal denervation; renal nerve stimulation; renal sympathetic nerve; Sodium - blood; streptozotocin; Sympathectomy; Sympathetic Nervous System - physiopathology; Time Factors; Vascular Resistance

Aim We assessed the role of renal sympathetic nervous system in the deterioration of renal hemodynamic and excretory functions in rats with streptozotocin (STZ)‐induced diabetic kidney disease (DKD). Methods Male Sprague–Dawley (SD) rats were induced with diabetes mellitus (DM) using STZ (55 mg/kg,...