Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder

• Published in: BJU international Vol. 109; no. 11; pp. 1716 - 1726
• Main Authors: Miyamoto, Hiroshi, Yao, Jorge L., Chaux, Alcides, Zheng, Yichun, Hsu, Iawen, Izumi, Koji, Chang, Chawnshang, Messing, Edward M., Netto, George J., Yeh, Shuyuan
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2012; Wiley-Blackwell; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; androgen receptor; Biological and medical sciences; Bladder cancer; bladder tumour; Carcinoma - metabolism; Carcinoma - pathology; Carcinoma - surgery; Cohort Studies; Female; Humans; immunohistochemistry; Male; Medical research; Medical sciences; Middle Aged; Mortality; Neoplasm Invasiveness; Neoplasm Staging; Nephrology. Urinary tract diseases; oestrogen receptor; Prognosis; progression; Receptors, Androgen - metabolism; Receptors, Estrogen - metabolism; recurrence; Tumors; Tumors of the urinary system; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - surgery; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Urothelium - metabolism; Urothelium - pathology; Immunohistochemistry; Estrogen receptor; Nephrology; Relapse; Urinary system disease; Prognosis; progression; Urinary tract disease; Urinary tract; oestrogen receptor; Bladder tumor; Urology; recurrence; Anatomic pathology; Urinary system; Urinary bladder; Androgen receptor; Evolution; Bladder disease; bladder tumour; Hormonal receptor; Urothelium

What's known on the subject? and What does the study add? Steroid hormone receptor signals have been implicated in bladder tumourigenesis and tumour progression. The expression of androgen and/or oestrogen receptors has been assessed in bladder cancer, leading to conflicting data of expression...