Resveratrol inhibited the metastatic behaviors of cisplatin‐resistant human oral cancer cells via phosphorylation of ERK/p‐38 and suppression of MMP‐2/9

• Published in: Journal of food biochemistry Vol. 45; no. 6; pp. e13666 - n/a
• Main Authors: Chang, Wen‐Shin, Tsai, Chia‐Wen, Yang, Jai‐Sing, Hsu, Yuan‐Man, Shih, Liang‐Chun, Chiu, Hong‐Yi, Bau, Da‐Tian, Tsai, Fuu‐Jen
• Format: Journal Article
• Language: English
• Published: United States 01.06.2021
• Subjects: cancer therapy; Carcinoma, Squamous Cell; Cell Line, Tumor; cisplatin; Cisplatin - pharmacology; cisplatin resistance; drug resistance; Humans; invasion; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; metastasis; migration; mouth neoplasms; Mouth Neoplasms - drug therapy; neoplasm cells; oral cancer; p38 Mitogen-Activated Protein Kinases; Phosphorylation; plant estrogens; resveratrol; Resveratrol - pharmacology; squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck; migration; invasion; metastasis; resveratrol; cisplatin resistance; oral cancer

Cisplatin resistance is a major clinical problem in the clinical management of oral squamous cell carcinoma (OSCC) patients. Resveratrol is a natural phytoestrogen with antitumor activities. Whether resveratrol can overcome cisplatin resistance and prevent metastasis in OSCC cells is not known. In t...