Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers

• Published in: Medicinal research reviews Vol. 32; no. 2; pp. 326 - 348
• Main Authors: Zen, Ke, Zhang, Chen-Yu
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.03.2012
• Subjects: biomarker; Biomarkers, Tumor - blood; cancer diagnosis; circulating; Humans; microarray; microRNA (miRNA); MicroRNAs - blood; MicroRNAs - genetics; Monitoring, Physiologic; Neoplasms - classification; Neoplasms - diagnosis; Prognosis; qRT-PCR; Solexa

Specific and sensitive non‐invasive biomarkers for the detection of human epithelial malignancies are urgently required to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs (miRNAs) are 19–24 nt noncoding RNAs that are frequently dysregulated in cancer and have shown great pro...