Expression of VEGF gene isoforms in a rat segmental bone defect model treated with EPCs

• Published in: Journal of orthopaedic trauma Vol. 26; no. 12; p. 689
• Main Authors: Li, Ru, Nauth, Aaron, Li, Claire, Qamirani, Erion, Atesok, Kivanc, Schemitsch, Emil H
• Format: Journal Article
• Language: English
• Published: United States 01.12.2012
• Subjects: Animals; Endothelial Cells - metabolism; Endothelial Cells - transplantation; Femoral Fractures - metabolism; Femoral Fractures - surgery; Protein Isoforms - metabolism; Rats; Stem Cell Transplantation - methods; Stem Cells - metabolism; Treatment Outcome; Up-Regulation; Vascular Endothelial Growth Factor A - metabolism

Angiogenesis and osteogenesis are essential for bone growth, fracture repair, and bone remodeling. Vascular endothelial growth factor (VEGF) has an important role in bone repair by promoting angiogenesis and osteogenesis. In our previous study, endothelial progenitor cells (EPCs) promoted bone heali...