Diagnostic pitfalls in the evaluation of fine needle aspiration cytology of the thyroid: correlation with histopathology in 260 cases

Fine needle aspiration cytology (FNAC) of the thyroid is a non-invasive, cost-effective screening procedure that is valuable for distinguishing neoplastic lesions from non-neoplastic nodules. The aim of this study was to determine the diagnostic accuracy of FNACs performed at our institution by corr...

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Published inCytopathology (Oxford) Vol. 20; no. 2; pp. 103 - 108
Main Authors Haberal, A.N, Toru, S, Özen, Ö, Arat, Z, Bilezikçi, B
Format Journal Article
LanguageEnglish
Published Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.04.2009
Blackwell Publishing Ltd
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Biopsy, Fine-Needle
Carcinoma, Papillary - diagnosis
Carcinoma, Papillary - pathology
Child
cytodiagnosis
Diagnosis, Differential
Diagnostic Errors
diagnostic pitfalls
Female
fine needle aspiration cytology
Hashimoto Disease - diagnosis
Hashimoto Disease - pathology
Humans
Male
Middle Aged
sensitivity
Sensitivity and Specificity
specificity
thyroid gland
Thyroid Gland - pathology
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
Young Adult
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Abstract Fine needle aspiration cytology (FNAC) of the thyroid is a non-invasive, cost-effective screening procedure that is valuable for distinguishing neoplastic lesions from non-neoplastic nodules. The aim of this study was to determine the diagnostic accuracy of FNACs performed at our institution by correlating FNAC results with histopathological diagnoses. Two hundred and seventy-one aspiration cytology specimens followed by thyroidectomy were included in the study, and the results of 260 adequate FNACs were compared with their histological diagnoses. The sensitivity and specificity of thyroid FNAC for detecting neoplasia were 92.6% and 91.6%, respectively. There were 15 (5.7%) false positives and six (2.3%) false negatives. The results showed that follicular cells that exhibit some of the features of papillary carcinoma could be observed in a cytology slide of Hashimoto's thyroiditis, leading to a diagnostic pitfall. In addition, cellularity and overlapping cytological criteria in hyperplasia might lead to a false diagnosis.
AbstractList Objectives:  Fine needle aspiration cytology (FNAC) of the thyroid is a non‐invasive, cost‐effective screening procedure that is valuable for distinguishing neoplastic lesions from non‐neoplastic nodules. The aim of this study was to determine the diagnostic accuracy of FNACs performed at our institution by correlating FNAC results with histopathological diagnoses. Methods:  Two hundred and seventy‐one aspiration cytology specimens followed by thyroidectomy were included in the study, and the results of 260 adequate FNACs were compared with their histological diagnoses. Results:  The sensitivity and specificity of thyroid FNAC for detecting neoplasia were 92.6% and 91.6%, respectively. There were 15 (5.7%) false positives and six (2.3%) false negatives. Conclusions:  The results showed that follicular cells that exhibit some of the features of papillary carcinoma could be observed in a cytology slide of Hashimoto’s thyroiditis, leading to a diagnostic pitfall. In addition, cellularity and overlapping cytological criteria in hyperplasia might lead to a false diagnosis.
OBJECTIVESFine needle aspiration cytology (FNAC) of the thyroid is a non-invasive, cost-effective screening procedure that is valuable for distinguishing neoplastic lesions from non-neoplastic nodules. The aim of this study was to determine the diagnostic accuracy of FNACs performed at our institution by correlating FNAC results with histopathological diagnoses.METHODSTwo hundred and seventy-one aspiration cytology specimens followed by thyroidectomy were included in the study, and the results of 260 adequate FNACs were compared with their histological diagnoses.RESULTSThe sensitivity and specificity of thyroid FNAC for detecting neoplasia were 92.6% and 91.6%, respectively. There were 15 (5.7%) false positives and six (2.3%) false negatives.CONCLUSIONSThe results showed that follicular cells that exhibit some of the features of papillary carcinoma could be observed in a cytology slide of Hashimoto's thyroiditis, leading to a diagnostic pitfall. In addition, cellularity and overlapping cytological criteria in hyperplasia might lead to a false diagnosis.
Fine needle aspiration cytology (FNAC) of the thyroid is a non-invasive, cost-effective screening procedure that is valuable for distinguishing neoplastic lesions from non-neoplastic nodules. The aim of this study was to determine the diagnostic accuracy of FNACs performed at our institution by correlating FNAC results with histopathological diagnoses. Two hundred and seventy-one aspiration cytology specimens followed by thyroidectomy were included in the study, and the results of 260 adequate FNACs were compared with their histological diagnoses. The sensitivity and specificity of thyroid FNAC for detecting neoplasia were 92.6% and 91.6%, respectively. There were 15 (5.7%) false positives and six (2.3%) false negatives. The results showed that follicular cells that exhibit some of the features of papillary carcinoma could be observed in a cytology slide of Hashimoto's thyroiditis, leading to a diagnostic pitfall. In addition, cellularity and overlapping cytological criteria in hyperplasia might lead to a false diagnosis.
Objectives:  Fine needle aspiration cytology (FNAC) of the thyroid is a non‐invasive, cost‐effective screening procedure that is valuable for distinguishing neoplastic lesions from non‐neoplastic nodules. The aim of this study was to determine the diagnostic accuracy of FNACs performed at our institution by correlating FNAC results with histopathological diagnoses. Methods:  Two hundred and seventy‐one aspiration cytology specimens followed by thyroidectomy were included in the study, and the results of 260 adequate FNACs were compared with their histological diagnoses. Results:  The sensitivity and specificity of thyroid FNAC for detecting neoplasia were 92.6% and 91.6%, respectively. There were 15 (5.7%) false positives and six (2.3%) false negatives. Conclusions:  The results showed that follicular cells that exhibit some of the features of papillary carcinoma could be observed in a cytology slide of Hashimoto’s thyroiditis, leading to a diagnostic pitfall. In addition, cellularity and overlapping cytological criteria in hyperplasia might lead to a false diagnosis.
Fine needle aspiration cytology (FNAC) of the thyroid is a non-invasive, cost-effective screening procedure that is valuable for distinguishing neoplastic lesions from non-neoplastic nodules. The aim of this study was to determine the diagnostic accuracy of FNACs performed at our institution by correlating FNAC results with histopathological diagnoses. Two hundred and seventy-one aspiration cytology specimens followed by thyroidectomy were included in the study, and the results of 260 adequate FNACs were compared with their histological diagnoses. The sensitivity and specificity of thyroid FNAC for detecting neoplasia were 92.6% and 91.6%, respectively. There were 15 (5.7%) false positives and six (2.3%) false negatives. The results showed that follicular cells that exhibit some of the features of papillary carcinoma could be observed in a cytology slide of Hashimoto's thyroiditis, leading to a diagnostic pitfall. In addition, cellularity and overlapping cytological criteria in hyperplasia might lead to a false diagnosis.
Author Toru, S.
Haberal, A. N.
Arat, Z.
Özen, Ö.
Bilezikçi, B.
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  article-title: Fine‐needle aspirates of follicular lesions of the thyroid gland: the intermediate‐type smear
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Snippet Fine needle aspiration cytology (FNAC) of the thyroid is a non-invasive, cost-effective screening procedure that is valuable for distinguishing neoplastic...
Objectives:  Fine needle aspiration cytology (FNAC) of the thyroid is a non‐invasive, cost‐effective screening procedure that is valuable for distinguishing...
Objectives:  Fine needle aspiration cytology (FNAC) of the thyroid is a non‐invasive, cost‐effective screening procedure that is valuable for distinguishing...
OBJECTIVESFine needle aspiration cytology (FNAC) of the thyroid is a non-invasive, cost-effective screening procedure that is valuable for distinguishing...
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StartPage 103
SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
Biopsy, Fine-Needle
Carcinoma, Papillary - diagnosis
Carcinoma, Papillary - pathology
Child
cytodiagnosis
Diagnosis, Differential
Diagnostic Errors
diagnostic pitfalls
Female
fine needle aspiration cytology
Hashimoto Disease - diagnosis
Hashimoto Disease - pathology
Humans
Male
Middle Aged
sensitivity
Sensitivity and Specificity
specificity
thyroid gland
Thyroid Gland - pathology
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
Young Adult
Title Diagnostic pitfalls in the evaluation of fine needle aspiration cytology of the thyroid: correlation with histopathology in 260 cases
URI https://api.istex.fr/ark:/67375/WNG-3Z832PDP-3/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1365-2303.2008.00594.x
https://www.ncbi.nlm.nih.gov/pubmed/18713250
https://search.proquest.com/docview/67097266
Volume 20
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