Association of MSX1 gene polymorphisms and maxillary lateral incisor agenesis in Non-syndromic cleft lip and/or palate individuals
To investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and palate (NSCL/P) in a South Indian population. The study sample was divided into four groups: Group I: Twenty five Cleft lip and palate (NSCL/P) subjects...
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| Published in | Journal of oral biology and craniofacial research (Amsterdam) Vol. 15; no. 2; pp. 440 - 443 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.03.2025
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2212-4268 2212-4276 |
| DOI | 10.1016/j.jobcr.2025.02.003 |
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| Abstract | To investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and palate (NSCL/P) in a South Indian population.
The study sample was divided into four groups: Group I: Twenty five Cleft lip and palate (NSCL/P) subjects with unilateral/bilateral congenitally missing maxillary lateral incisors, without agenesis of any other permanent teeth, Group II: Twenty five individuals with NSCL/P and a full complement of teeth, Group III: Twenty five non-cleft individuals with unilateral/bilateral congenitally missing maxillary lateral incisors and Control group: Twenty five healthy individuals with normal teeth development and without orofacial defects. MSX1 gene polymorphisms rs12532, rs1042484 and rs11726039 were genotyped by Sanger sequencing method with pre designed primer using ABI 3730 DNA sequencer. Associations were tested using Pearson Chi-square analysis.
The three SNPs, rs12532, rs1042484 and rs11726039 of MSX1 gene exhibited polymorphism. rs12532 was associated with reduced risk of maxillary lateral incisor agenesis in NSCL/P subjects. rs1042484 had significant association with the NSCL/P without maxillary lateral incisor agenesis (full complement of teeth) subjects. rs11726039 showed significant association with NSCL/P with or without maxillary lateral incisor agenesis.
The present study on a South Indian population revealed a significant association between the MSX1 gene polymorphisms and tooth agenesis in NSCL/P subjects. Keywords: MSX1, non syndromic cleft lip and palate, lateral incisor agenesis. |
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| AbstractList | AbstractBackgroundTo investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and palate (NSCL/P) in a South Indian population. MethodsThe study sample was divided into four groups: Group I: Twenty five Cleft lip and palate (NSCL/P) subjects with unilateral/bilateral congenitally missing maxillary lateral incisors, without agenesis of any other permanent teeth, Group II: Twenty five individuals with NSCL/P and a full complement of teeth, Group III: Twenty five non-cleft individuals with unilateral/bilateral congenitally missing maxillary lateral incisors and Control group: Twenty five healthy individuals with normal teeth development and without orofacial defects. MSX1 gene polymorphisms rs12532, rs1042484 and rs11726039 were genotyped by Sanger sequencing method with pre designed primer using ABI 3730 DNA sequencer. Associations were tested using Pearson Chi-square analysis. ResultsThe three SNPs, rs12532, rs1042484 and rs11726039 of MSX1 gene exhibited polymorphism. rs12532 was associated with reduced risk of maxillary lateral incisor agenesis in NSCL/P subjects. rs1042484 had significant association with the NSCL/P without maxillary lateral incisor agenesis (full complement of teeth) subjects. rs11726039 showed significant association with NSCL/P with or without maxillary lateral incisor agenesis. ConclusionThe present study on a South Indian population revealed a significant association between the MSX1 gene polymorphisms and tooth agenesis in NSCL/P subjects. Keywords: MSX1, non syndromic cleft lip and palate, lateral incisor agenesis. To investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and palate (NSCL/P) in a South Indian population.BackgroundTo investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and palate (NSCL/P) in a South Indian population.The study sample was divided into four groups: Group I: Twenty five Cleft lip and palate (NSCL/P) subjects with unilateral/bilateral congenitally missing maxillary lateral incisors, without agenesis of any other permanent teeth, Group II: Twenty five individuals with NSCL/P and a full complement of teeth, Group III: Twenty five non-cleft individuals with unilateral/bilateral congenitally missing maxillary lateral incisors and Control group: Twenty five healthy individuals with normal teeth development and without orofacial defects. MSX1 gene polymorphisms rs12532, rs1042484 and rs11726039 were genotyped by Sanger sequencing method with pre designed primer using ABI 3730 DNA sequencer. Associations were tested using Pearson Chi-square analysis.MethodsThe study sample was divided into four groups: Group I: Twenty five Cleft lip and palate (NSCL/P) subjects with unilateral/bilateral congenitally missing maxillary lateral incisors, without agenesis of any other permanent teeth, Group II: Twenty five individuals with NSCL/P and a full complement of teeth, Group III: Twenty five non-cleft individuals with unilateral/bilateral congenitally missing maxillary lateral incisors and Control group: Twenty five healthy individuals with normal teeth development and without orofacial defects. MSX1 gene polymorphisms rs12532, rs1042484 and rs11726039 were genotyped by Sanger sequencing method with pre designed primer using ABI 3730 DNA sequencer. Associations were tested using Pearson Chi-square analysis.The three SNPs, rs12532, rs1042484 and rs11726039 of MSX1 gene exhibited polymorphism. rs12532 was associated with reduced risk of maxillary lateral incisor agenesis in NSCL/P subjects. rs1042484 had significant association with the NSCL/P without maxillary lateral incisor agenesis (full complement of teeth) subjects. rs11726039 showed significant association with NSCL/P with or without maxillary lateral incisor agenesis.ResultsThe three SNPs, rs12532, rs1042484 and rs11726039 of MSX1 gene exhibited polymorphism. rs12532 was associated with reduced risk of maxillary lateral incisor agenesis in NSCL/P subjects. rs1042484 had significant association with the NSCL/P without maxillary lateral incisor agenesis (full complement of teeth) subjects. rs11726039 showed significant association with NSCL/P with or without maxillary lateral incisor agenesis.The present study on a South Indian population revealed a significant association between the MSX1 gene polymorphisms and tooth agenesis in NSCL/P subjects. Keywords: MSX1, non syndromic cleft lip and palate, lateral incisor agenesis.ConclusionThe present study on a South Indian population revealed a significant association between the MSX1 gene polymorphisms and tooth agenesis in NSCL/P subjects. Keywords: MSX1, non syndromic cleft lip and palate, lateral incisor agenesis. Background: To investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and palate (NSCL/P) in a South Indian population. Methods: The study sample was divided into four groups: Group I: Twenty five Cleft lip and palate (NSCL/P) subjects with unilateral/bilateral congenitally missing maxillary lateral incisors, without agenesis of any other permanent teeth, Group II: Twenty five individuals with NSCL/P and a full complement of teeth, Group III: Twenty five non-cleft individuals with unilateral/bilateral congenitally missing maxillary lateral incisors and Control group: Twenty five healthy individuals with normal teeth development and without orofacial defects. MSX1 gene polymorphisms rs12532, rs1042484 and rs11726039 were genotyped by Sanger sequencing method with pre designed primer using ABI 3730 DNA sequencer. Associations were tested using Pearson Chi-square analysis. Results: The three SNPs, rs12532, rs1042484 and rs11726039 of MSX1 gene exhibited polymorphism. rs12532 was associated with reduced risk of maxillary lateral incisor agenesis in NSCL/P subjects. rs1042484 had significant association with the NSCL/P without maxillary lateral incisor agenesis (full complement of teeth) subjects. rs11726039 showed significant association with NSCL/P with or without maxillary lateral incisor agenesis. Conclusion: The present study on a South Indian population revealed a significant association between the MSX1 gene polymorphisms and tooth agenesis in NSCL/P subjects. Keywords: MSX1, non syndromic cleft lip and palate, lateral incisor agenesis. To investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and palate (NSCL/P) in a South Indian population. The study sample was divided into four groups: Group I: Twenty five Cleft lip and palate (NSCL/P) subjects with unilateral/bilateral congenitally missing maxillary lateral incisors, without agenesis of any other permanent teeth, Group II: Twenty five individuals with NSCL/P and a full complement of teeth, Group III: Twenty five non-cleft individuals with unilateral/bilateral congenitally missing maxillary lateral incisors and Control group: Twenty five healthy individuals with normal teeth development and without orofacial defects. MSX1 gene polymorphisms rs12532, rs1042484 and rs11726039 were genotyped by Sanger sequencing method with pre designed primer using ABI 3730 DNA sequencer. Associations were tested using Pearson Chi-square analysis. The three SNPs, rs12532, rs1042484 and rs11726039 of MSX1 gene exhibited polymorphism. rs12532 was associated with reduced risk of maxillary lateral incisor agenesis in NSCL/P subjects. rs1042484 had significant association with the NSCL/P without maxillary lateral incisor agenesis (full complement of teeth) subjects. rs11726039 showed significant association with NSCL/P with or without maxillary lateral incisor agenesis. The present study on a South Indian population revealed a significant association between the MSX1 gene polymorphisms and tooth agenesis in NSCL/P subjects. Keywords: MSX1, non syndromic cleft lip and palate, lateral incisor agenesis. |
| Author | Padmanaban, Sridevi Kailasam, Vignesh Ramanathan, Gnanasambandan Kamalakannan, Dhanyashri Paul, Solomon F.D. |
| Author_xml | – sequence: 1 givenname: Dhanyashri surname: Kamalakannan fullname: Kamalakannan, Dhanyashri organization: Department of Orthodontics and Dentofacial Orthopaedics, Sri Ramachandra Dental College, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India – sequence: 2 givenname: Vignesh orcidid: 0000-0002-2848-9368 surname: Kailasam fullname: Kailasam, Vignesh email: theorthodontist@gmail.com organization: Department of Orthodontics and Dentofacial Orthopaedics, Sri Ramachandra Dental College, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India – sequence: 3 givenname: Sridevi surname: Padmanaban fullname: Padmanaban, Sridevi organization: Department of Orthodontics and Dentofacial Orthopaedics, Sri Ramachandra Dental College, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India – sequence: 4 givenname: Solomon F.D. surname: Paul fullname: Paul, Solomon F.D. organization: Department of Human genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India – sequence: 5 givenname: Gnanasambandan surname: Ramanathan fullname: Ramanathan, Gnanasambandan organization: Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40092365$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1620/tjem.226.243 10.1093/bioinformatics/bth457 10.1111/j.1365-263X.2011.01184.x 10.1089/dna.2010.1208 10.1597/15-107 10.3389/fcell.2020.592271 10.1016/j.ydbio.2010.01.031 10.1038/nature15393 10.4317/medoral.18357 10.1597/10-178 10.1111/odi.13127 10.1597/16-037 10.3346/jkms.2013.28.4.522 10.1111/odi.14174 10.1056/NEJMoa032909 10.1093/aje/153.10.1007 10.1177/0022034514527617 10.1002/gepi.10255 10.1016/j.ijporl.2015.04.034 |
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| Snippet | To investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and palate... AbstractBackgroundTo investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft... Background: To investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and... |
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| Title | Association of MSX1 gene polymorphisms and maxillary lateral incisor agenesis in Non-syndromic cleft lip and/or palate individuals |
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