Modulation of intracellular glutathione affects adipogenesis in 3T3-L1 cells

• Published in: Journal of cellular physiology Vol. 226; no. 8; pp. 2016 - 2024
• Main Authors: Vigilanza, Paola, Aquilano, Katia, Baldelli, Sara, Rotilio, Giuseppe, Ciriolo, Maria Rosa
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2011
• Subjects: 3T3-L1 Cells; Adipocytes - drug effects; Adipocytes - metabolism; Adipogenesis - drug effects; Animals; Buthionine Sulfoximine - pharmacology; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Proteins - biosynthesis; Enzyme Inhibitors - pharmacology; Glutamate-Cysteine Ligase - biosynthesis; Glutathione - analogs & derivatives; Glutathione - metabolism; Glutathione - pharmacology; Mice; PPAR gamma - biosynthesis; PPAR gamma - metabolism; Stilbenes - pharmacology; Triglycerides - biosynthesis

Impairment of redox homeostasis has been extensively associated with obesity, as a consequence of the chronic inflammatory state present in overweight subjects. Deregulation of glutathione (GSH), the most important non‐enzymatic intracellular anti‐oxidant, induces insulin resistance in mature adipoc...