Comparison of the skeletal effects induced by daily administration of PTHrP (1-36) and PTHrP (107-139) to ovariectomized mice

• Published in: Journal of cellular physiology Vol. 227; no. 4; pp. 1752 - 1760
• Main Authors: de Castro, Luis Fernández, Lozano, Daniel, Portal-Núñez, Sergio, Maycas, Marta, De la Fuente, Mónica, Caeiro, José R., Esbrit, Pedro
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2012
• Subjects: Animals; Bone Remodeling - drug effects; Bone Remodeling - genetics; Bone Resorption - genetics; Bone Resorption - prevention & control; Female; Glycoproteins - genetics; Injections, Subcutaneous; Intercellular Signaling Peptides and Proteins - genetics; Mice; Mice, Inbred C57BL; Osteogenesis - drug effects; Osteogenesis - genetics; Oxidative Stress; Parathyroid Hormone-Related Protein - administration & dosage; Peptide Fragments - administration & dosage; RNA, Messenger - genetics; RNA, Messenger - metabolism

We here compared the changes induced by subcutaneous injection of PTHrP (1–36) or PTHrP (107–139) (80 µg/kg/day, 5 days/week for 4 or 8 weeks) in bone histology and bone remodeling factors, and in bone marrow cells (BMCs) ex vivo, in ovariectomized (OVX) mice. We also examined the osteogenic effects...