Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis

• Published in: Critical care medicine Vol. 45; no. 1; p. e97
• Main Authors: Li, Xiaoou, Kondo, Yutaka, Bao, Yi, Staudenmaier, Laura, Lee, Albert, Zhang, Jingping, Ledderose, Carola, Junger, Wolfgang G
• Format: Journal Article
• Language: English
• Published: United States 01.01.2017
• Subjects: Adenosine Triphosphate - physiology; Animals; Apyrase - pharmacology; Chemotaxis, Leukocyte - immunology; Humans; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Activation; Neutrophils - physiology; Sepsis - immunology; Sepsis - mortality; Suramin - pharmacology

Sepsis remains an unresolved clinical problem. Therapeutic strategies focusing on inhibition of neutrophils (polymorphonuclear neutrophils) have failed, which indicates that a more detailed understanding of the underlying pathophysiology of sepsis is required. Polymorphonuclear neutrophil activation...