MicroRNA‐19a enhances proliferation of bronchial epithelial cells by targeting TGFβR2 gene in severe asthma

• Published in: Allergy (Copenhagen) Vol. 70; no. 2; pp. 212 - 219
• Main Authors: Haj‐Salem, I., Fakhfakh, R., Bérubé, J.‐C., Jacques, E., Plante, S., Simard, M. J., Bossé, Y., Chakir, J.
• Format: Journal Article
• Language: English
• Published: Denmark 01.02.2015
• Subjects: 3' Untranslated Regions; Adult; Aged; Asthma - diagnosis; Asthma - genetics; Biopsy; Case-Control Studies; Cell Proliferation; epithelial cells; Female; Forced Expiratory Volume; Gene Expression Regulation; Humans; Male; microRNA; MicroRNAs - genetics; Middle Aged; Phosphorylation; Protein-Serine-Threonine Kinases - genetics; Receptors, Transforming Growth Factor beta - genetics; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; RNA Interference; RNA, Messenger - genetics; severe asthma; Severity of Illness Index; Smad3 Protein - metabolism; Sputum - cytology; TGF‐β receptor 2; Young Adult; severe asthma; epithelial cells; microRNA; TGF-β receptor 2

Background Allergic asthma is characterized by inflammation and airway remodeling. Bronchial epithelium is considered a key player in coordinating airway wall remodeling. In mild asthma, the epithelium is damaged and fails to proliferate and to repair, whereas in severe asthma, the epithelium is hig...