Gene x environment interactions impact endometrial function and the menstrual cycle: PROGINS, life history, anthropometry, and physical activity

• Published in: American journal of human biology Vol. 25; no. 5; pp. 681 - 694
• Main Authors: Rowe, Elizabeth J., Eisenstein, Toby K., Meissler, Joseph, Rockwell, L. Christie
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2013; Wiley Subscription Services, Inc
• Subjects: Adult; Anthropometry; Endometrium - physiology; Energy Metabolism; Female; Gene-Environment Interaction; Humans; Menstrual Cycle; Middle Aged; Motor Activity; Progesterone - metabolism; Receptors, Progesterone - genetics; Receptors, Progesterone - metabolism; Reproduction; Young Adult

Objectives We assessed the impact of a high frequency, functionally significant allelic variant of the progesterone receptor gene (PROGINS) on endometrial function and menstrual cycle characteristics. Further we asked whether PROGINS moderates the impact of life history characteristics, anthropometr...