Melatonin Ameliorates Neuropsychiatric Behaviors, Gut Microbiome, and Microbiota-Derived Metabolites in Rats with Chronic Sleep Deprivation

• Published in: International journal of molecular sciences Vol. 24; no. 23; p. 16820
• Main Authors: Li, Bingcong, Hsieh, Yin-Ru, Lai, Wen-De, Tung, Te-Hsuan, Chen, Yu-Xuan, Yang, Chia-Hui, Fang, Yu-Chiao, Huang, Shih-Yi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2023
• Subjects: Bacteria; Behavior; Bile acids; Digestive system; Endocrine system; Fatty acids; Feces; Gut microbiota; Gut-brain axis; Insomnia; Medical research; Medicine, Experimental; Melatonin; Mental depression; Mental disorders; Mental health; Metabolites; Microbiota; Microbiota (Symbiotic organisms); Sleep deprivation; Sleep disorders; Steroids; Massachusetts; Taiwan; sleep deprivation; intestinal metabolites; cognitive; depression-like behavior; melatonin

With the increasing prevalence of sleep deprivation (SD)-related disorders, the effective treatment of sleep disorders has become a critical health research topic. Thus, we hypothesized and investigated the effectiveness of a 3-week melatonin intervention on neuropsychiatric behavioral responses med...