Electrotransfer of CpG free plasmids enhances gene expression in skin

• Published in: Bioelectrochemistry (Amsterdam, Netherlands) Vol. 130; p. 107343
• Main Authors: Chabot, S, Bellard, E, Reynes, J P, Tiraby, G, Teissie, J, Golzio, M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier BV 01.12.2019; Elsevier
• Subjects: Biotechnology; CpG islands; Cytosine; Deoxyribonucleic acid; DNA; DNA vaccines; Electroporation; Fluorescence; Gene expression; Gene therapy; Gene transfer; Green fluorescent protein; Guanine; Life Sciences; Plasmids; Skin; Therapeutic applications; Transgenes; Vaccination; Vaccines; Wound healing; Electroporation; Skin; CpG free plasmid; Imaging; Electropermeabilization; Gene electrotransfer; skin; gene electrotransfer; electroporation; electropermeabilization; imaging

Skin is a very suitable target for gene therapy and DNA vaccination due to its accessibility, its surface and its ability to produce transgenes. Gene electrotransfer (GET) to the skin is under development for clinical applications for DNA vaccine or local treatment such as wound healing. Local treat...