Plagiochin E, an antifungal active macrocyclic bis(bibenzyl), induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway

• Published in: Biochimica et biophysica acta Vol. 1800; no. 4; pp. 439 - 447
• Main Authors: Wu, Xiu-Zhen, Chang, Wen-Qiang, Cheng, Ai-Xia, Sun, Ling-Mei, Lou, Hong-Xiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2010
• Subjects: Annexin A5 - drug effects; Annexin A5 - metabolism; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Bridged-Ring Compounds - chemistry; Bridged-Ring Compounds - isolation & purification; Bridged-Ring Compounds - pharmacology; Candida albicans; Candida albicans - cytology; Candida albicans - drug effects; Candida albicans - enzymology; Candida albicans - genetics; Caspase Inhibitors; Cell Cycle - drug effects; Cell cycle arrest; DNA Primers; Flow Cytometry; Macrocyclic Compounds - chemistry; Macrocyclic Compounds - isolation & purification; Macrocyclic Compounds - pharmacology; Marchantia - chemistry; Metacaspase; Models, Molecular; Molecular Conformation; Plagiochin E; Protease Inhibitors - pharmacology; Reverse Transcriptase Polymerase Chain Reaction; RNA, Fungal - genetics; RNA, Fungal - isolation & purification; Stilbenes - chemistry; Stilbenes - isolation & purification; Stilbenes - pharmacology; Candida albicans; Cell cycle arrest; Plagiochin E; Metacaspase; Apoptosis

Plagiochin E (PLE) is an antifungal active macrocyclic bis(bibenzyl) isolated from liverwort Marchantia polymorpha L. To elucidate the mechanism of action, previous studies revealed that the antifungal effect of PLE was associated with the accumulation of ROS, an important regulator of apoptosis in...