Impact of Vehicle Physicochemical Properties on Modeling-Based Predictions of Cyclosporine Ophthalmic Emulsion Bioavailability and Tear Film Breakup Time

• Published in: Journal of pharmaceutical sciences Vol. 108; no. 1; pp. 620 - 629
• Main Authors: Walenga, Ross L., Babiskin, Andrew H., Zhang, Xinyuan, Absar, Mohammad, Zhao, Liang, Lionberger, Robert A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019; Elsevier
• Subjects: bioavailability; bioequivalence; Biological Availability; Conjunctiva - metabolism; Cornea - metabolism; cyclosporine; Cyclosporine - pharmacokinetics; Drug Compounding - methods; emulsion; Emulsions - pharmacokinetics; Excipients - chemistry; Humans; Immunosuppressive Agents - pharmacokinetics; Ophthalmic Solutions - pharmacokinetics; Tears - metabolism; Therapeutic Equivalency; viscosity; cyclosporine; emulsion; viscosity; bioavailability; bioequivalence

Several physicochemical parameters are thought to affect in vivo performance of cyclosporine ophthalmic emulsion, including globule size distribution, viscosity profile as a function of applied shear, pH, zeta potential, osmolality, and surface tension. Using a modeling approach, this study predicts...