Impact of Vehicle Physicochemical Properties on Modeling-Based Predictions of Cyclosporine Ophthalmic Emulsion Bioavailability and Tear Film Breakup Time - Walenga, Ross L.; Babiskin, Andrew H.; Zhang, Xinyuan; Absar, Mohammad; Zhao, Liang; Lionberger, Robert A. (Journal of pharmaceutical sciences, 2019)
Keywords: bioavailability; bioequivalence; Biological Availability; Conjunctiva - metabolism; Cornea - metabolism; cyclosporine; Cyclosporine - pharmacokinetics; Drug Compounding - methods; emulsion; Emulsions - pharmacokinetics; Excipients - chemistry; Humans; Immunosuppressive Agents - pharmacokinetics; Ophthalmic Solutions - pharmacokinetics; Tears - metabolism; Therapeutic Equivalency; viscosity; cyclosporine; emulsion; viscosity; bioavailability; bioequivalence