Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 44; no. 6; pp. 1043 - 1054
• Main Authors: Mahmoudi, Ebrahim, Fitzsimmons, Chantel, Geaghan, Michael P., Shannon Weickert, Cynthia, Atkins, Joshua R., Wang, Xi, Cairns, Murray J.
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.05.2019; Springer International Publishing
• Subjects: Alternative splicing; Autopsy; Behavioral plasticity; Bioavailability; Circular RNA; Cognitive ability; Gene regulation; Gene silencing; Gray Matter - metabolism; Humans; Mental disorders; MicroRNAs - metabolism; miRNA; Neurological diseases; Non-coding RNA; Pathophysiology; Post-transcription; Prefrontal cortex; Prefrontal Cortex - metabolism; RNA, Circular - metabolism; Schizophrenia; Schizophrenia - metabolism; Substantia grisea; Synaptic plasticity; Tissue Banks

Circular RNAs (circRNAs) are a covalently closed subclass of non-coding RNA molecules formed by back splicing of linear precursor RNA. These molecules are relatively stable and particularly abundant in the mammalian brain and therefore may participate in neural development and function. With the eme...