RET Fusions Define a Unique Molecular and Clinicopathologic Subtype of Non–Small-Cell Lung Cancer

• Published in: Journal of clinical oncology Vol. 30; no. 35; pp. 4352 - 4359
• Main Authors: Wang, Rui, Hu, Haichuan, Pan, Yunjian, Li, Yuan, Ye, Ting, Li, Chenguang, Luo, Xiaoyang, Wang, Lei, Li, Hang, Zhang, Yang, Li, Fei, Lu, Yongming, Lu, Qiong, Xu, Jie, Garfield, David, Shen, Lei, Ji, Hongbin, Pao, William, Sun, Yihua, Chen, Haiquan
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Society of Clinical Oncology 10.12.2012
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Female; Gene Fusion; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Medical sciences; Middle Aged; Pneumology; Proto-Oncogene Proteins c-ret - genetics; Tumors; Tumors of the respiratory system and mediastinum; Lung disease; Anatomic pathology; Cancerology; Histopathology; Respiratory disease; Lung cancer; C-Onc gene; Bronchus disease; Malignant tumor; non-small cell lung carcinoma; Protooncogene; Cancer
• ISSN: 0732-183X; 1527-7755; 1527-7755
• DOI: 10.1200/JCO.2012.44.1477

The RET fusion gene has been recently described in a subset of non-small-cell lung cancers (NSCLCs). Because we have limited knowledge about these tumors, this study was aimed at determining the clinicopathologic characteristics of patients with NSCLC harboring the RET fusion gene. We examined the R...