Development of a prolonged-release gastroretentive tablet formulation of ciprofloxacin hydrochloride: Pharmacokinetic characterization in healthy human volunteers

• Published in: International journal of pharmaceutics Vol. 409; no. 1; pp. 128 - 136
• Main Authors: Mostafavi, Abolfazl, Emami, Jaber, Varshosaz, Jaleh, Davies, Neal M., Rezazadeh, Mahboubeh
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 16.05.2011; Elsevier
• Subjects: Adult; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - pharmacokinetics; Area Under Curve; Biological and medical sciences; Chromatography, High Pressure Liquid - methods; Ciprofloxacin; Ciprofloxacin - administration & dosage; Ciprofloxacin - pharmacokinetics; Cross-Over Studies; Delayed-Action Preparations; drugs; Floating; gastrointestinal system; Gastroretentive; General pharmacology; high performance liquid chromatography; HPLC; Humans; In vivo; in vivo studies; Kinetics; Male; Medical sciences; Microbial Sensitivity Tests; pathogens; Pharmaceutical technology. Pharmaceutical industry; pharmacokinetics; Pharmacology. Drug treatments; physical properties; polymers; Polymers - chemistry; Reproducibility of Results; Tablets; Time Factors; volunteers; Young Adult; In vivo; Gastroretentive; Ciprofloxacin; Floating; HPLC; Human; Pharmaceutical technology; Healthy subject; Controlled release form; HPLC chromatography; Characterization; Fluoroquinolone derivatives; Formulation; Dosage form; Tablet; Antibacterial agent; Pharmacokinetics; Quinolone derivatives

Controlled-release floating tablets (●), conventional immediate release tablets (○), and co-administration of conventional immediate release and controlled release floating tablets (▴) in healthy volunteers. The fluroquinolone anti-biotic ciprofloxacin is primarily dissolved and absorbed from the up...