Modulation of synaptic plasticity by brain estrogen in the hippocampus

• Published in: Biochimica et biophysica acta Vol. 1800; no. 10; pp. 1030 - 1044
• Main Authors: Mukai, Hideo, Kimoto, Tetsuya, Hojo, Yasushi, Kawato, Suguru, Murakami, Gen, Higo, Shimpei, Hatanaka, Yusuke, Ogiue-Ikeda, Mari
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2010
• Subjects: Androgen; Animals; Estradiol; Estradiol - metabolism; Estrogen; Estrogen receptor; Estrogen Receptor alpha - metabolism; Estrogen Receptor beta - metabolism; Estrogens - metabolism; Female; Hippocampus; Hippocampus - cytology; Hippocampus - metabolism; Humans; LTD; LTP; Male; Neuronal Plasticity - physiology; Neurons - cytology; Neurons - metabolism; Neurosteroid; Spine; Synapses - metabolism; Synaptic plasticity; DHEA; PREG; Estrogen receptor; AMPA; DPN; Spine; Estrogen; LTP; Neurosteroid; CNQX; Estradiol; estrone; DHT; LC-MS/MS; T; PPT; StAR; Synaptic plasticity; HSD; NMDA; 17β-estradiol; PSD; Androgen; GPR30; ACSF; RIA; LTD; Hippocampus
• ISSN: 0304-4165; 0006-3002; 1872-8006
• DOI: 10.1016/j.bbagen.2009.11.002

The hippocampus is a center for learning and memory as well as a target of Alzheimer's disease in aged humans. Synaptic modulation by estrogen is essential to understand the molecular mechanisms of estrogen replacement therapy. Because the local synthesis of estrogen occurs in the hippocampus o...