Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents

• Published in: Psychological medicine Vol. 52; no. 6; pp. 1175 - 1182
• Main Authors: Li, Jin, Liu, Bing, Banaschewski, Tobias, Bokde, Arun L.W., Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Jiang, Tianzi
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.04.2022
• Subjects: Adolescent; Adolescents; Avoidable; Brain mechanisms; Brain structure; Cortex; Genetic susceptibility; Genome-wide association studies; Genome-Wide Association Study; Genomics; Humans; Molecular modelling; Multicenter studies; Multicenter Studies as Topic; Neuroimaging; Original Article; Path analysis; Prefrontal Cortex; Self report; Smoking; Smoking - genetics; Teenagers; Tobacco; Tobacco Smoking; Tobacco Use; orbitofrontal cortex; Cortical volume; polygenic risk score; tobacco use; smoking

Tobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the g...