Lymphocytic mitochondrial aconitase activity is reduced in Alzheimer's disease and mild cognitive impairment

• Published in: Journal of Alzheimer's disease Vol. 44; no. 2; p. 649
• Main Authors: Mangialasche, Francesca, Baglioni, Mauro, Cecchetti, Roberta, Kivipelto, Miia, Ruggiero, Carmelinda, Piobbico, Danilo, Kussmaul, Lothar, Monastero, Roberto, Brancorsini, Stefano, Mecocci, Patrizia
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2015
• Subjects: Aconitate Hydratase - blood; Aged; Alzheimer Disease - blood; Biomarkers - blood; Blotting, Western; Cognitive Dysfunction - blood; Disease Progression; Female; Free Radicals - metabolism; Humans; Lymphocytes - metabolism; Male; Mental Status Schedule; Mitochondria - metabolism; Polymerase Chain Reaction; RNA, Messenger - metabolism; Vitamin E - blood; free radicals; Alzheimer disease; antioxidants; mitochondria; reactive oxygen species; Aconitase (aconitate hydratase); reactive nitrogen species; mild cognitive impairment; oxidative stress; lymphocyte

Specific mechanisms behind the role of oxidative/nitrosative stress and mitochondrial dysfunction in Alzheimer's disease (AD) pathogenesis remain elusive. Mitochondrial aconitase (ACO2) is a Krebs cycle enzyme sensitive to free radical-mediated damage. We assessed activity and expression of ACO...