In vivo electroporation of skeletal muscle: threshold, efficacy and relation to electric field distribution

• Published in: Biochimica et biophysica acta Vol. 1428; no. 2; pp. 233 - 240
• Main Authors: Gehl, Julie, Sørensen, Thyge H., Nielsen, Kurt, Raskmark, Povl, Nielsen, Steen L., Skovsgaard, Torben, Mir, Lluis M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.08.1999
• Subjects: 51-chromium-EDTA; Animals; Chromium - chemistry; E-field; Edetic Acid - chemistry; Electrodes; Electromagnetic Fields; Electropermeabilization; Electroporation; Electroporation - methods; Female; Mathematics; Mice; Mice, Inbred C57BL; Mouse; Muscle; Muscle Fibers, Skeletal - chemistry; Muscle, Skeletal - chemistry; Permeability; Electroporation; Muscle; E-field; Mouse; 51-chromium-EDTA; Electropermeabilization

In vivo electroporation is increasingly being used to deliver small molecules as well as DNA to tissues. The aim of this study was to quantitatively investigate in vivo electroporation of skeletal muscle, and to determine the threshold for permeabilization. We designed a quantitative method to study...