Transposable element exonization generates a reservoir of evolving and functional protein isoforms

• Published in: Cell Vol. 187; no. 26; pp. 7603 - 7620.e22
• Main Authors: Arribas, Yago A., Baudon, Blandine, Rotival, Maxime, Suárez, Guadalupe, Bonté, Pierre-Emmanuel, Casas, Vanessa, Roubert, Apollinaire, Klein, Paul, Bonnin, Elisa, Mchich, Basma, Legoix, Patricia, Baulande, Sylvain, Sadacca, Benjamin, Diharce, Julien, Waterfall, Joshua J., Etchebest, Catherine, Carrascal, Montserrat, Goudot, Christel, Quintana-Murci, Lluís, Burbage, Marianne, Merlotti, Antonela, Amigorena, Sebastian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.12.2024; Elsevier
• Subjects: Alternative Splicing - genetics; cryptic splice sites; DNA Transposable Elements - genetics; Evolution, Molecular; exon birth; Exons - genetics; Humans; Immunology; Life Sciences; natural selection; non-canonical proteome; protein evolution; protein isoforms; Protein Isoforms - genetics; Protein Isoforms - metabolism; protein structure; proteome; Proteomics; ribosome profiling; ribosomes; Ribosomes - metabolism; RNA Splice Sites - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; transcriptome; Transcriptome - genetics; transcriptomics; transposable elements; transposons; unannotated splicing; protein structure; ribosome profiling; protein evolution; protein isoforms; proteomics; non-canonical proteome; unannotated splicing; cryptic splice sites; transposable elements; exon birth; Protein structure

Alternative splicing enhances protein diversity in different ways, including through exonization of transposable elements (TEs). Recent transcriptomic analyses identified thousands of unannotated spliced transcripts with exonizing TEs, but their contribution to the proteome and biological relevance...