Transposable element exonization generates a reservoir of evolving and functional protein isoforms - Arribas, Yago A.; Baudon, Blandine; Rotival, Maxime; Suárez, Guadalupe; Bonté, Pierre-Emmanuel; Casas, Vanessa; Roubert, Apollinaire; Klein, Paul; Bonnin, Elisa; Mchich, Basma; Legoix, Patricia; Baulande, Sylvain; et al. (Cell, 2024)
Keywords: Alternative Splicing - genetics; cryptic splice sites; DNA Transposable Elements - genetics; Evolution, Molecular; exon birth; Exons - genetics; Humans; Immunology; Life Sciences; natural selection; non-canonical proteome; protein evolution; protein isoforms; Protein Isoforms - genetics; Protein Isoforms - metabolism; protein structure; proteome; Proteomics; ribosome profiling; ribosomes; Ribosomes - metabolism; RNA Splice Sites - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; transcriptome; Transcriptome - genetics; transcriptomics; transposable elements; transposons; unannotated splicing; protein structure; ribosome profiling; protein evolution; protein isoforms; proteomics; non-canonical proteome; unannotated splicing; cryptic splice sites; transposable elements; exon birth; Protein structure