Physiologically based pharmacokinetic model of lapatinib developed in mice and scaled to humans - Hudachek, Susan F.; Gustafson, Daniel L. (Journal of pharmacokinetics and pharmacodynamics, 2013)
Keywords: Administration, Oral; Animals; Antineoplastic Agents - pharmacokinetics; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Female; Humans; Liver - metabolism; Mice; Models, Biological; Neoplasms - drug therapy; Neoplasms - metabolism; Original Paper; Pharmacology/Toxicology; Pharmacy; Quinazolines - pharmacokinetics; Quinazolines - pharmacology; Tissue Distribution - physiology; Veterinary Medicine/Veterinary Science; Breast cancer; Lapatinib; Physiologically based pharmacokinetic modeling; Tyrosine kinase inhibitor