Juvenile Administration of Methylphenidate Attenuates Adult Hippocampal Neurogenesis

• Published in: Biological psychiatry (1969) Vol. 60; no. 10; pp. 1121 - 1130
• Main Authors: Lagace, Diane C., Yee, Jessica K., Bolaños, Carlos A., Eisch, Amelia J.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.11.2006; Elsevier Science
• Subjects: ADHD; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal - drug effects; Biological and medical sciences; BrdU; Bromodeoxyuridine - metabolism; Cell Proliferation - drug effects; Central Nervous System Stimulants - pharmacology; development; Female; hippocampus; Hippocampus - cytology; Hippocampus - drug effects; Hippocampus - growth & development; Immunohistochemistry - methods; Male; Medical sciences; Methylphenidate - pharmacology; Neurons - drug effects; Neuropharmacology; Organogenesis - drug effects; Pharmacology. Drug treatments; Photic Stimulation - adverse effects; Pregnancy; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; psychostimulant; Rats; Ritalin; Stress, Psychological - drug therapy; Stress, Psychological - pathology; Time Factors; ADHD; Ritalin; development; hippocampus; BrdU; psychostimulant; Human; CNS stimulant; Hyperactivity; Psychotropic; Central nervous system; psycho- stimulant; Neurogenesis; Encephalon; Chemotherapy; Treatment; Attentional disorder; Piperidine derivatives; Development; Adult; Attention disorder with hyperactivity; Hippocampus; Methylphenidate

The neural consequences of early-life exposure to methylphenidate (MPH; Ritalin) are of great interest given the widespread, and sometimes inappropriate, use in children. Here we examine the impact of juvenile MPH exposure on adult hippocampal neurogenesis. Rats received MPH (2.0 mg/kg, intraperiton...