Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort

• Published in: Psychological medicine Vol. 50; no. 6; pp. 1020 - 1031
• Main Authors: Tozzi, Leonardo, Garczarek, Lisa, Janowitz, Deborah, Stein, Dan J, Wittfeld, Katharina, Dobrowolny, Henrik, Lagopoulos, Jim, Hatton, Sean N, Hickie, Ian B, Carballedo, Angela, Brooks, Samantha J, Vuletic, Daniella, Uhlmann, Anne, Veer, Ilya M, Walter, Henrik, Bülow, Robin, Völzke, Henry, Klinger-König, Johanna, Schnell, Knut, Schoepf, Dieter, Grotegerd, Dominik, Opel, Nils, Dannlowski, Udo, Kugel, Harald, Schramm, Elisabeth, Konrad, Carsten, Kircher, Tilo, Jüksel, Dilara, Nenadić, Igor, Krug, Axel, Hahn, Tim, Steinsträter, Olaf, Redlich, Ronny, Zaremba, Dario, Zurowski, Bartosz, Fu, Cynthia H Y, Dima, Danai, Cole, James, Grabe, Hans J, Connolly, Colm G, Yang, Tony T, Ho, Tiffany C, LeWinn, Kaja Z, Li, Meng, Groenewold, Nynke A, Salminen, Lauren E, Walter, Martin, Simmons, Alan N, van Erp, Theo G M, Jahanshad, Neda, Baune, Bernhard T, van der Wee, Nic J A, van Tol, Marie-Jose, Penninx, Brenda W J H, Hibar, Derrek P, Thompson, Paul M, Veltman, Dick J, Schmaal, Lianne, Frodl, Thomas
• Format: Journal Article
• Language: English
• Published: England Cambridge University Press 01.04.2020
• Subjects: Abuse; Adolescent; Adult; Adults; Age; Age composition; Age Factors; Aged; Aged, 80 and over; Brain; Brain Cortical Thickness; Brain structure; Case-Control Studies; Cerebral Cortex - pathology; Child; Child Abuse; Child abuse & neglect; Childhood; Children; Cognition; Cohort Studies; Cortex; Cortex (cingulate); Cortex (parietal); Depressive Disorder, Major - pathology; Depressive personality disorders; Emotions; Female; Gyrus Cinguli - pathology; Humans; Magnetic Resonance Imaging; Male; Males; Maturation; Medical diagnosis; Men; Mental depression; Mental disorders; Middle Aged; Neuroimaging; Parietal lobe; Parietal Lobe - pathology; Prefrontal Cortex - pathology; Regions; Severity; Subtypes; Superior temporal sulcus; Surface area; Temporal lobe; Temporal Lobe - pathology; Temporal lobes; Theory of mind; Time; Trauma; Violence; Young Adult; ENIGMA; Childhood maltreatment; major depressive disorder; cortical thickness

Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age. Within the ENIGMA-MDD network, sever...