Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort
Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age. Within the ENIGMA-MDD network, sever...
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| Published in | Psychological medicine Vol. 50; no. 6; pp. 1020 - 1031 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Cambridge University Press
01.04.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.
Within the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.
CM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.
Severity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind. |
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| AbstractList | BACKGROUNDChildhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.METHODSWithin the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.RESULTSCM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.CONCLUSIONSSeverity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind. Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age. Within the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer. CM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions. Severity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind. |
| Author | Lagopoulos, Jim Connolly, Colm G Stein, Dan J Vuletic, Daniella Baune, Bernhard T Frodl, Thomas Li, Meng Yang, Tony T Jüksel, Dilara Groenewold, Nynke A Bülow, Robin Veltman, Dick J Nenadić, Igor Ho, Tiffany C Konrad, Carsten Dima, Danai Garczarek, Lisa Brooks, Samantha J van Erp, Theo G M Thompson, Paul M Klinger-König, Johanna Kugel, Harald Grabe, Hans J Schmaal, Lianne Steinsträter, Olaf Salminen, Lauren E Fu, Cynthia H Y Walter, Henrik Hatton, Sean N Veer, Ilya M Zurowski, Bartosz Schoepf, Dieter Janowitz, Deborah Hickie, Ian B Tozzi, Leonardo Völzke, Henry Redlich, Ronny Schnell, Knut Dobrowolny, Henrik Krug, Axel Carballedo, Angela LeWinn, Kaja Z Hahn, Tim Jahanshad, Neda Grotegerd, Dominik Walter, Martin Cole, James van der Wee, Nic J A Zaremba, Dario Uhlmann, Anne Schramm, Elisabeth Opel, Nils Dannlowski, Udo Hibar, Derrek P van Tol, Marie-Jose Kircher, Tilo Penninx, Brenda W J H Wittfeld, Katharina Simmons, Alan N |
| AuthorAffiliation | 39 Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA 40 Discipline of Psychiatry, School of Medicine, University of Adelaide, SA 5005 Adelaide, Australia 41 Department of Psychiatry, Melbourne Medical School, The University of Melbourne, VIC 3010 Melbourne, Australia 24 Core Facility Brain Imaging, Faculty of Medicine, Philipps-University of Marburg, Germany 31 Department of Biomedical Sciences, Florida State University Tallahassee, FL, USA 42 The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia 10 Department of Psychiatry, University of Vermont, Burlington, VT, USA 21 Psychiatric University Clinic, Basel, Switzerland 29 Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK 11 Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, |
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Psychology, School of Arts and Social Sciences, City, University of London, London, UK – name: 45 Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands – name: 38 School of Medicine, Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA – name: 35 Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of California, Marina del Rey, CA, USA – name: 17 Department of Psychiatry and Psychotherapy, University of Bonn, Germany, and Department of Psychiatry and Psychotherapy, Vitos Weil-Lahn, Hesse, Germany – name: 27 Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK – name: 30 Department of Psychiatry & Langley Porter Psychiatric Institute, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA – name: 32 Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of California, San Francisco (UCSF), USA – name: 26 School of Psychology, College of Applied Health and Communities, University of East London, London, UK – name: 36 Department of Psychiatry and Psychotherapy, University of Tuebingen, Germany – name: 1 Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany – name: 4 SAMRC Unit on Risk & Resilience in Mental Disorders, UCT Department of Psychiatry and Mental Health, Cape Town, South Africa – name: 23 Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany – name: 10 Department of Psychiatry, University of Vermont, Burlington, VT, USA – name: 9 School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, UK – name: 40 Discipline of Psychiatry, School of Medicine, University of Adelaide, SA 5005 Adelaide, Australia – name: 20 Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg, Germany – name: 43 Department of Psychiatry, Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands – name: 15 Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany – name: 44 Department of Biomedical Sciences of Cells and Systems, Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands – name: 47 Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia – name: 41 Department of Psychiatry, Melbourne Medical School, The University of Melbourne, VIC 3010 Melbourne, Australia – name: 46 Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia – name: 34 Leibniz Institute for Neurobiology, Magdeburg, Germany – name: 14 Department of General Psychiatry, University Hospital Heidelberg, Germany – name: 3 Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany – name: 48 German Center of Neurodegenerative Diseases (DZNE), Site Magdeburg, Germany – name: 6 Brain and Mind Centre, University of Sydney, Camperdown, Australia – name: 29 Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK – name: 21 Psychiatric University Clinic, Basel, Switzerland – name: 39 Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA – name: 25 Center for Integrative Psychiatry, University of Lübeck, Lübeck, Germany – name: 42 The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia – name: 5 German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Germany – name: 22 Department of Psychiatry and Psychotherapy, Agaplesion Diakoniklinikum, Rotenburg, Germany – name: 31 Department of Biomedical Sciences, Florida State University Tallahassee, FL, USA – name: 33 Department of Psychology and Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA – name: 16 Department of Psychiatry and Psychotherapy, Asklepios Fachklinikum Göttingen, Göttingen, Germany – name: 19 Institute of Clinical Radiology, University of Münster, Germany – name: 2 Department of Psychiatry and Behavioral Sciences, Stanford University, California, USA |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31084657$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © Cambridge University Press 2019 |
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| Keywords | ENIGMA Childhood maltreatment major depressive disorder cortical thickness |
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| Snippet | Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM... BackgroundChildhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine... BACKGROUNDChildhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine... |
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| SubjectTerms | Abuse Adolescent Adult Adults Age Age composition Age Factors Aged Aged, 80 and over Brain Brain Cortical Thickness Brain structure Case-Control Studies Cerebral Cortex - pathology Child Child Abuse Child abuse & neglect Childhood Children Cognition Cohort Studies Cortex Cortex (cingulate) Cortex (parietal) Depressive Disorder, Major - pathology Depressive personality disorders Emotions Female Gyrus Cinguli - pathology Humans Magnetic Resonance Imaging Male Males Maturation Medical diagnosis Men Mental depression Mental disorders Middle Aged Neuroimaging Parietal lobe Parietal Lobe - pathology Prefrontal Cortex - pathology Regions Severity Subtypes Superior temporal sulcus Surface area Temporal lobe Temporal Lobe - pathology Temporal lobes Theory of mind Time Trauma Violence Young Adult |
| Title | Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort |
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