Evaluation of a PET Radioligand to Image O -GlcNAcase in Brain and Periphery of Rhesus Monkey and Knock-Out Mouse

• Published in: Journal of Nuclear Medicine Vol. 60; no. 1; pp. 129 - 134
• Main Authors: Paul, Soumen, Haskali, Mohammad B., Liow, Jeih-San, Zoghbi, Sami S., Barth, Vanessa N., Kolodrubetz, Marcy Comly, Bond, Michelle R., Morse, Cheryl L., Gladding, Robert L., Frankland, Michael P., Kant, Nancy, Slieker, Lawrence, Shcherbinin, Sergey, Nuthall, Hugh N., Zanotti-Fregonara, Paolo, Hanover, John A., Jesudason, Cynthia, Pike, Victor W., Innis, Robert B.
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.01.2019
• Subjects: Acetamides - pharmacokinetics; Alzheimer's disease; Amygdala; Animals; beta-N-Acetylhexosaminidases - metabolism; Biological Transport; Brain; Brain - diagnostic imaging; Brain - metabolism; Fluorine isotopes; Image Processing, Computer-Assisted; Kidneys; Kinetics; Laboratory animals; Ligands; Liver; Macaca mulatta; Medical imaging; Mice; Mice, Knockout; Monkeys; Neostriatum; Neurodegenerative diseases; Neuroimaging; Neurology; Organs; Pharmacokinetics; Pharmacology; Phosphorylation; Piperidines - pharmacokinetics; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Proteins; Radiation therapy; Radioactivity; Radioisotopes; Radiometry; Selectivity; Spleen; Tau protein; Thiazoles - pharmacokinetics; Tissue Distribution; Tomography; O-GlcNAcase; tau; Alzheimer disease; PET

Accumulation of hyperphosphorylated tau, a microtubule-associated protein, plays an important role in the progression of Alzheimer disease. Animal studies suggest that one strategy for treating Alzheimer disease and related tauopathies may be inhibition of -GlcNAcase (OGA), which may subsequently de...