Evaluation of a PET Radioligand to Image O -GlcNAcase in Brain and Periphery of Rhesus Monkey and Knock-Out Mouse - Paul, Soumen; Haskali, Mohammad B.; Liow, Jeih-San; Zoghbi, Sami S.; Barth, Vanessa N.; Kolodrubetz, Marcy Comly; Bond, Michelle R.; Morse, Cheryl L.; Gladding, Robert L.; Frankland, Michael P.; Kant, Nancy; Slieker, Lawrence; et al. (Journal of Nuclear Medicine, 2019)
Keywords: Acetamides - pharmacokinetics; Alzheimer's disease; Amygdala; Animals; beta-N-Acetylhexosaminidases - metabolism; Biological Transport; Brain; Brain - diagnostic imaging; Brain - metabolism; Fluorine isotopes; Image Processing, Computer-Assisted; Kidneys; Kinetics; Laboratory animals; Ligands; Liver; Macaca mulatta; Medical imaging; Mice; Mice, Knockout; Monkeys; Neostriatum; Neurodegenerative diseases; Neuroimaging; Neurology; Organs; Pharmacokinetics; Pharmacology; Phosphorylation; Piperidines - pharmacokinetics; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Proteins; Radiation therapy; Radioactivity; Radioisotopes; Radiometry; Selectivity; Spleen; Tau protein; Thiazoles - pharmacokinetics; Tissue Distribution; Tomography; O-GlcNAcase; tau; Alzheimer disease; PET