Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases

• Published in: International journal of molecular sciences Vol. 25; no. 24; p. 13446
• Main Authors: Xing, Cencan, Chen, Hongyu, Bi, Wangyu, Lei, Tong, Hang, Zhongci, Du, Hongwu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.12.2024
• Subjects: Addictive behaviors; Advertising executives; Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer's disease; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - drug therapy; Amyotrophic Lateral Sclerosis - metabolism; Animals; Antipsychotics; Anxiety; Brain research; Cognition & reasoning; Development and progression; Disease; Dopamine; Drugs; Health aspects; Humans; Hypothalamus; Lorcaserin; Medical research; Medicine, Experimental; Memory; Mental depression; Mental illness; Metabolites; Motility; Nausea; Nervous system; Nervous system diseases; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - metabolism; Neurons; Neurophysiology; Palonosetron; Parkinson Disease - drug therapy; Parkinson Disease - metabolism; Physiological aspects; Physiology; Proteins; Psychosis; Psychotropic drugs; Receptors, Serotonin - metabolism; Schizophrenia; Serotonin; Serotonin - metabolism; Sleep; Vomiting; Mississippi; neurodegenerative diseases; clinical trials; therapeutic target; 5-HT

There is increasing interest in the potential therapeutic role of 5-HT (serotonin) in the treatment of neurodegenerative diseases, which are characterized by the progressive degeneration and death of nerve cells. 5-HT is a vital neurotransmitter that plays a central role in regulating mood, cognitio...