ESC reverses epithelial mesenchymal transition induced by transforming growth factor-β via inhibition of Smad signal pathway in HepG2 liver cancer cells

• Published in: Cancer cell international Vol. 15; no. 1; p. 114
• Main Authors: Liu, Xiao-Ni, Wang, Shuang, Yang, Qing, Wang, Ya-Jie, Chen, De-Xi, Zhu, Xiao-Xin
• Format: Journal Article
• Language: English
• Published: England BioMed Central 10.12.2015
• Subjects: Liver cancer; Primary Research; Hepatocellular carcinoma; Stellera chamaejasme L; Epithelial mesenchymal transition; Metastasis; Smad signaling pathway; Transforming growth factor

Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studi...