Degradation of selenoprotein S and selenoprotein K through PPARγ-mediated ubiquitination is required for adipocyte differentiation
Adipocyte differentiation is known to be related with endoplasmic reticulum (ER) stress. We have reported that selenoprotein S (SelS) and selenoprotein K (SelK) have a function in the regulation of ER stress and ER-associated degradation. However, the association between adipocyte differentiation an...
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Published in | Cell death and differentiation Vol. 26; no. 6; pp. 1007 - 1023 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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01.06.2019
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Abstract | Adipocyte differentiation is known to be related with endoplasmic reticulum (ER) stress. We have reported that selenoprotein S (SelS) and selenoprotein K (SelK) have a function in the regulation of ER stress and ER-associated degradation. However, the association between adipocyte differentiation and the ER-resident selenoproteins, SelS and SelK, is unclear. In this study, we found that the levels of SelS and SelK were decreased during adipocyte differentiation and were inversely related to the levels of peroxisome proliferator-activated receptor γ (PPARγ), a central regulator of adipogenesis. It has been recently reported that PPARγ has E3 ubiquitin ligase activity. Here, we report that PPARγ directly interacts with both SelS and SelK via its ligand-binding domain to induce ubiquitination and degradation of the selenoproteins. Lysine residues at the 150th position of SelS and the 47th and 48th positions of SelK were the target sites for ubiquitination by PPARγ. We also found that adipocyte differentiation was inhibited when either SelS or SelK was not degraded by PPARγ. Thus, these data indicate that PPARγ-mediated ubiquitination and degradation of SelS and SelK is required for adipocyte differentiation. |
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AbstractList | Adipocyte differentiation is known to be related with endoplasmic reticulum (ER) stress. We have reported that selenoprotein S (SelS) and selenoprotein K (SelK) have a function in the regulation of ER stress and ER-associated degradation. However, the association between adipocyte differentiation and the ER-resident selenoproteins, SelS and SelK, is unclear. In this study, we found that the levels of SelS and SelK were decreased during adipocyte differentiation and were inversely related to the levels of peroxisome proliferator-activated receptor γ (PPARγ), a central regulator of adipogenesis. It has been recently reported that PPARγ has E3 ubiquitin ligase activity. Here, we report that PPARγ directly interacts with both SelS and SelK via its ligand-binding domain to induce ubiquitination and degradation of the selenoproteins. Lysine residues at the 150th position of SelS and the 47th and 48th positions of SelK were the target sites for ubiquitination by PPARγ. We also found that adipocyte differentiation was inhibited when either SelS or SelK was not degraded by PPARγ. Thus, these data indicate that PPARγ-mediated ubiquitination and degradation of SelS and SelK is required for adipocyte differentiation. |
Author | Lee, Jea Hwang Jang, Jun Ki Jin, Yunjung Ham, Minju Kang, Hyunwoo Kim, Ick Young Ko, Kwan Young |
Author_xml | – sequence: 1 givenname: Jea Hwang surname: Lee fullname: Lee, Jea Hwang organization: Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, 02114, USA – sequence: 2 givenname: Jun Ki surname: Jang fullname: Jang, Jun Ki organization: Division of Life Sciences, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul, 02841, Republic of Korea – sequence: 3 givenname: Kwan Young surname: Ko fullname: Ko, Kwan Young organization: Division of Life Sciences, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul, 02841, Republic of Korea – sequence: 4 givenname: Yunjung surname: Jin fullname: Jin, Yunjung organization: Division of Life Sciences, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul, 02841, Republic of Korea – sequence: 5 givenname: Minju surname: Ham fullname: Ham, Minju organization: Division of Life Sciences, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul, 02841, Republic of Korea – sequence: 6 givenname: Hyunwoo surname: Kang fullname: Kang, Hyunwoo organization: Division of Life Sciences, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul, 02841, Republic of Korea – sequence: 7 givenname: Ick Young surname: Kim fullname: Kim, Ick Young email: ickkim@korea.ac.kr organization: Division of Life Sciences, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul, 02841, Republic of Korea. ickkim@korea.ac.kr |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30082770$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/j.bbrc.2006.12.183 10.1126/science.1209038 10.1016/S0002-9440(10)63151-3 10.1038/nrm2066 10.1371/journal.pone.0064284 10.1038/onc.2013.504 10.1128/MCB.14.8.5501 10.1016/j.bbamcr.2012.09.001 10.1111/febs.13052 10.1089/ars.2015.6478 10.1074/jbc.M006577200 10.1038/oby.2008.473 10.1038/sj.ijo.0800732 10.18632/oncotarget.10337 10.1016/j.virol.2016.05.001 10.1074/jbc.M113.534529 10.4049/jimmunol.1002878 10.1074/jbc.M603355200 10.1038/nrm3198 10.1126/science.1083516 10.1074/jbc.M115.680215 10.1152/ajpendo.00608.2012 10.1016/j.bbamcr.2014.04.002 10.1172/JCI200419900 10.1038/nm.3159 10.1074/jbc.M111.234559 10.1007/s11912-010-0139-7 10.1016/j.abb.2010.08.001 10.1074/jbc.M110.152934 10.1016/j.cmet.2006.07.001 10.1038/nature06902 10.1373/clinchem.2007.100156 10.1146/annurev.biochem.77.061307.091829 10.1194/jlr.M034603 10.1152/ajpendo.00380.2010 10.1074/jbc.274.18.12632 10.1006/bbrc.1998.8393 10.1038/25931 10.1016/j.cell.2005.11.026 10.1074/jbc.M109.006288 10.1016/j.cmet.2009.04.009 10.1038/cdd.2013.181 10.1016/j.bbagrm.2015.08.002 10.3892/etm.2013.1237 10.1016/j.bbrc.2017.03.060 10.1007/s00125-012-2809-5 10.1016/j.molmed.2011.07.010 10.1101/gad.1709008 10.1621/nrs.08004 10.1002/ajmg.a.32035 10.1074/jbc.M109.052928 10.1002/cbin.10644 10.1016/j.cell.2009.01.041 10.1074/jbc.M110.126821 10.1126/science.2538923 10.1074/jbc.M111.310920 10.1074/jbc.M111.260547 10.1074/jbc.M001297200 10.1007/s10549-016-4013-7 |
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References | A Majdalawieh (180_CR43) 2010; 8 GV Kryukov (180_CR24) 2003; 300 KL Spalding (180_CR3) 2008; 453 H Sha (180_CR40) 2009; 9 S Park (180_CR59) 2015; 1849 CY Kim (180_CR18) 2013; 54 SF Li (180_CR31) 2013; 304 V Chau (180_CR48) 1989; 243 LA Barness (180_CR1) 2007; 143A M Cnop (180_CR30) 2012; 18 J Yan (180_CR39) 2016; 40 MI Lefterova (180_CR10) 2008; 22 UH Gandhi (180_CR17) 2011; 286 T Ito (180_CR42) 2004; 164 T Akune (180_CR7) 2004; 113 S Hauser (180_CR45) 2000; 275 D Finley (180_CR49) 1994; 14 A Lanczky (180_CR55) 2016; 160 K Basen-Engquist (180_CR52) 2011; 13 S Ferranti de (180_CR2) 2008; 54 JK Jang (180_CR27) 2017; 486 Y David (180_CR50) 2011; 286 SR Farmer (180_CR8) 2006; 4 O Beekum van (180_CR12) 2009; 17 KS Kim (180_CR56) 2010; 285 VA Shchedrina (180_CR29) 2011; 286 OJ Noh (180_CR35) 2010; 285 YM Cho (180_CR23) 2014; 281 M Lehrke (180_CR44) 2005; 123 GU Jeong (180_CR61) 2016; 495 JH Kim (180_CR13) 2014; 21 YH Jeon (180_CR36) 2014; 1843 AM Szasz (180_CR54) 2016; 7 Y Hou (180_CR15) 2012; 3 KH Kim (180_CR25) 2007; 354 S Du (180_CR26) 2010; 502 J Han (180_CR20) 2013; 56 ED Rosen (180_CR6) 2006; 7 Y Zhang (180_CR37) 2011; 300 JH Lee (180_CR22) 2015; 290 T Miyahara (180_CR41) 2000; 275 JH Lee (180_CR21) 2014; 289 P Tontonoz (180_CR9) 2008; 77 M Ahmadian (180_CR14) 2013; 19 P Walter (180_CR19) 2011; 334 E Kelly (180_CR28) 2009; 284 YH Park (180_CR57) 2012; 1823 Y Hou (180_CR16) 2014; 33 AD Jacobson (180_CR46) 2009; 284 I Dreher (180_CR38) 1998; 245 P Ballar (180_CR58) 2006; 281 IM Faust (180_CR4) 1978; 235 RT Nolte (180_CR33) 1998; 395 AG Cristancho (180_CR5) 2011; 12 CM Smas (180_CR11) 1999; 274 L Boukhzar (180_CR60) 2016; 24 P Xu (180_CR47) 2009; 137 S Verma (180_CR51) 2011; 186 I Tasdelen (180_CR34) 2013; 8 F Picard (180_CR53) 1998; 22 Y Zhao (180_CR32) 2013; 6 |
References_xml | – volume: 354 start-page: 127 year: 2007 ident: 180_CR25 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2006.12.183 contributor: fullname: KH Kim – volume: 3 year: 2012 ident: 180_CR15 publication-title: Nat Commun contributor: fullname: Y Hou – volume: 334 start-page: 1081 year: 2011 ident: 180_CR19 publication-title: Science doi: 10.1126/science.1209038 contributor: fullname: P Walter – volume: 164 start-page: 623 year: 2004 ident: 180_CR42 publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)63151-3 contributor: fullname: T Ito – volume: 7 start-page: 885 year: 2006 ident: 180_CR6 publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm2066 contributor: fullname: ED Rosen – volume: 8 start-page: e64284 year: 2013 ident: 180_CR34 publication-title: PLoS ONE doi: 10.1371/journal.pone.0064284 contributor: fullname: I Tasdelen – volume: 33 start-page: 5619 year: 2014 ident: 180_CR16 publication-title: Oncogene doi: 10.1038/onc.2013.504 contributor: fullname: Y Hou – volume: 14 start-page: 5501 year: 1994 ident: 180_CR49 publication-title: Mol Cell Biol doi: 10.1128/MCB.14.8.5501 contributor: fullname: D Finley – volume: 1823 start-page: 2217 year: 2012 ident: 180_CR57 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2012.09.001 contributor: fullname: YH Park – volume: 281 start-page: 5132 year: 2014 ident: 180_CR23 publication-title: FEBS J doi: 10.1111/febs.13052 contributor: fullname: YM Cho – volume: 24 start-page: 557 year: 2016 ident: 180_CR60 publication-title: Antioxid Redox Signal doi: 10.1089/ars.2015.6478 contributor: fullname: L Boukhzar – volume: 275 start-page: 35715 year: 2000 ident: 180_CR41 publication-title: J Biol Chem doi: 10.1074/jbc.M006577200 contributor: fullname: T Miyahara – volume: 17 start-page: 213 year: 2009 ident: 180_CR12 publication-title: Obesity doi: 10.1038/oby.2008.473 contributor: fullname: O Beekum van – volume: 22 start-page: 1088 year: 1998 ident: 180_CR53 publication-title: Int J Obes Relat Metab Disord doi: 10.1038/sj.ijo.0800732 contributor: fullname: F Picard – volume: 7 start-page: 49322 year: 2016 ident: 180_CR54 publication-title: Oncotarget doi: 10.18632/oncotarget.10337 contributor: fullname: AM Szasz – volume: 495 start-page: 71 year: 2016 ident: 180_CR61 publication-title: Virology doi: 10.1016/j.virol.2016.05.001 contributor: fullname: GU Jeong – volume: 289 start-page: 13758 year: 2014 ident: 180_CR21 publication-title: J Biol Chem doi: 10.1074/jbc.M113.534529 contributor: fullname: JH Lee – volume: 186 start-page: 2127 year: 2011 ident: 180_CR51 publication-title: J Immunol doi: 10.4049/jimmunol.1002878 contributor: fullname: S Verma – volume: 281 start-page: 35359 year: 2006 ident: 180_CR58 publication-title: J Biol Chem doi: 10.1074/jbc.M603355200 contributor: fullname: P Ballar – volume: 12 start-page: 722 year: 2011 ident: 180_CR5 publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm3198 contributor: fullname: AG Cristancho – volume: 300 start-page: 1439 year: 2003 ident: 180_CR24 publication-title: Science doi: 10.1126/science.1083516 contributor: fullname: GV Kryukov – volume: 290 start-page: 29941 year: 2015 ident: 180_CR22 publication-title: J Biol Chem doi: 10.1074/jbc.M115.680215 contributor: fullname: JH Lee – volume: 304 start-page: E990 year: 2013 ident: 180_CR31 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00608.2012 contributor: fullname: SF Li – volume: 1843 start-page: 1356 year: 2014 ident: 180_CR36 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2014.04.002 contributor: fullname: YH Jeon – volume: 113 start-page: 846 year: 2004 ident: 180_CR7 publication-title: J Clin Invest doi: 10.1172/JCI200419900 contributor: fullname: T Akune – volume: 19 start-page: 557 year: 2013 ident: 180_CR14 publication-title: Nat Med doi: 10.1038/nm.3159 contributor: fullname: M Ahmadian – volume: 286 start-page: 44104 year: 2011 ident: 180_CR50 publication-title: J Biol Chem doi: 10.1074/jbc.M111.234559 contributor: fullname: Y David – volume: 13 start-page: 71 year: 2011 ident: 180_CR52 publication-title: Curr Oncol Rep doi: 10.1007/s11912-010-0139-7 contributor: fullname: K Basen-Engquist – volume: 502 start-page: 137 year: 2010 ident: 180_CR26 publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2010.08.001 contributor: fullname: S Du – volume: 285 start-page: 40496 year: 2010 ident: 180_CR35 publication-title: J Biol Chem doi: 10.1074/jbc.M110.152934 contributor: fullname: OJ Noh – volume: 4 start-page: 263 year: 2006 ident: 180_CR8 publication-title: Cell Metab doi: 10.1016/j.cmet.2006.07.001 contributor: fullname: SR Farmer – volume: 453 start-page: 783 year: 2008 ident: 180_CR3 publication-title: Nature doi: 10.1038/nature06902 contributor: fullname: KL Spalding – volume: 54 start-page: 945 year: 2008 ident: 180_CR2 publication-title: Clin Chem doi: 10.1373/clinchem.2007.100156 contributor: fullname: S Ferranti de – volume: 77 start-page: 289 year: 2008 ident: 180_CR9 publication-title: Annu Rev Biochem doi: 10.1146/annurev.biochem.77.061307.091829 contributor: fullname: P Tontonoz – volume: 54 start-page: 2069 year: 2013 ident: 180_CR18 publication-title: J Lipid Res doi: 10.1194/jlr.M034603 contributor: fullname: CY Kim – volume: 300 start-page: E77 year: 2011 ident: 180_CR37 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00380.2010 contributor: fullname: Y Zhang – volume: 274 start-page: 12632 year: 1999 ident: 180_CR11 publication-title: J Biol Chem doi: 10.1074/jbc.274.18.12632 contributor: fullname: CM Smas – volume: 245 start-page: 101 year: 1998 ident: 180_CR38 publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1998.8393 contributor: fullname: I Dreher – volume: 395 start-page: 137 year: 1998 ident: 180_CR33 publication-title: Nature doi: 10.1038/25931 contributor: fullname: RT Nolte – volume: 123 start-page: 993 year: 2005 ident: 180_CR44 publication-title: Cell doi: 10.1016/j.cell.2005.11.026 contributor: fullname: M Lehrke – volume: 284 start-page: 16891 year: 2009 ident: 180_CR28 publication-title: J Biol Chem doi: 10.1074/jbc.M109.006288 contributor: fullname: E Kelly – volume: 9 start-page: 556 year: 2009 ident: 180_CR40 publication-title: Cell Metab doi: 10.1016/j.cmet.2009.04.009 contributor: fullname: H Sha – volume: 21 start-page: 594 year: 2014 ident: 180_CR13 publication-title: Cell Death Differ doi: 10.1038/cdd.2013.181 contributor: fullname: JH Kim – volume: 1849 start-page: 1237 year: 2015 ident: 180_CR59 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbagrm.2015.08.002 contributor: fullname: S Park – volume: 6 start-page: 937 year: 2013 ident: 180_CR32 publication-title: Exp Ther Med doi: 10.3892/etm.2013.1237 contributor: fullname: Y Zhao – volume: 486 start-page: 444 year: 2017 ident: 180_CR27 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2017.03.060 contributor: fullname: JK Jang – volume: 235 start-page: E279 year: 1978 ident: 180_CR4 publication-title: Am J Physiol contributor: fullname: IM Faust – volume: 56 start-page: 911 year: 2013 ident: 180_CR20 publication-title: Diabetologia doi: 10.1007/s00125-012-2809-5 contributor: fullname: J Han – volume: 18 start-page: 59 year: 2012 ident: 180_CR30 publication-title: Trends Mol Med doi: 10.1016/j.molmed.2011.07.010 contributor: fullname: M Cnop – volume: 22 start-page: 2941 year: 2008 ident: 180_CR10 publication-title: Genes Dev doi: 10.1101/gad.1709008 contributor: fullname: MI Lefterova – volume: 8 start-page: e004 year: 2010 ident: 180_CR43 publication-title: Nucl Recept Signal doi: 10.1621/nrs.08004 contributor: fullname: A Majdalawieh – volume: 143A start-page: 3016 year: 2007 ident: 180_CR1 publication-title: Am J Med Genet A doi: 10.1002/ajmg.a.32035 contributor: fullname: LA Barness – volume: 284 start-page: 35485 year: 2009 ident: 180_CR46 publication-title: J Biol Chem doi: 10.1074/jbc.M109.052928 contributor: fullname: AD Jacobson – volume: 40 start-page: 1033 year: 2016 ident: 180_CR39 publication-title: Cell Biol Int doi: 10.1002/cbin.10644 contributor: fullname: J Yan – volume: 137 start-page: 133 year: 2009 ident: 180_CR47 publication-title: Cell doi: 10.1016/j.cell.2009.01.041 contributor: fullname: P Xu – volume: 285 start-page: 40294 year: 2010 ident: 180_CR56 publication-title: J Biol Chem doi: 10.1074/jbc.M110.126821 contributor: fullname: KS Kim – volume: 243 start-page: 1576 year: 1989 ident: 180_CR48 publication-title: Science doi: 10.1126/science.2538923 contributor: fullname: V Chau – volume: 286 start-page: 42937 year: 2011 ident: 180_CR29 publication-title: J Biol Chem doi: 10.1074/jbc.M111.310920 contributor: fullname: VA Shchedrina – volume: 286 start-page: 27471 year: 2011 ident: 180_CR17 publication-title: J Biol Chem doi: 10.1074/jbc.M111.260547 contributor: fullname: UH Gandhi – volume: 275 start-page: 18527 year: 2000 ident: 180_CR45 publication-title: J Biol Chem doi: 10.1074/jbc.M001297200 contributor: fullname: S Hauser – volume: 160 start-page: 439 year: 2016 ident: 180_CR55 publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-016-4013-7 contributor: fullname: A Lanczky |
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SubjectTerms | Adipocytes Adipocytes - metabolism Adipogenesis Animals Cell Differentiation Endoplasmic reticulum HT29 Cells Humans Lysine MCF-7 Cells Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Obese Mutation PPAR gamma - genetics PPAR gamma - metabolism Selenoproteins Selenoproteins - genetics Selenoproteins - metabolism Tumor Cells, Cultured Ubiquitin Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitination |
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Title | Degradation of selenoprotein S and selenoprotein K through PPARγ-mediated ubiquitination is required for adipocyte differentiation |
URI | https://www.ncbi.nlm.nih.gov/pubmed/30082770 https://www.proquest.com/docview/2222645129/abstract/ https://search.proquest.com/docview/2084912660 https://pubmed.ncbi.nlm.nih.gov/PMC6748118 |
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