Development of a human stanniocalcin radioimmunoassay: serum and tissue hormone levels and pharmacokinetics in the rat

• Published in: Molecular and cellular endocrinology Vol. 162; no. 1; pp. 131 - 144
• Main Authors: De Niu, Ping, Radman, Dennis P, Jaworski, Eva M, Deol, Harminder, Gentz, Reiner, Su, Jeffrey, Olsen, Henrik S, Wagner, Graham F
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 25.04.2000
• Subjects: Animals; Cattle; Female; Glycoproteins - analysis; Glycoproteins - blood; Glycoproteins - metabolism; Half-Life; Hormone; Hormones - analysis; Hormones - blood; Hormones - metabolism; Human; Humans; Immunohistochemistry; Kinetics; Male; Models, Biological; Oncorhynchus mykiss; Pharmacokinetics; Radioimmunoassay - methods; Rat; Rats; Rats, Wistar; Recombinant Proteins - analysis; Recombinant Proteins - blood; Recombinant Proteins - pharmacokinetics; Stanniocalcin; Tissue Distribution; Tissue uptake; Stanniocalcin; Hormone; Human; Rat; Pharmacokinetics; Tissue uptake

Stanniocalcin (STC) is a polypeptide hormone that was first discovered in fish and recently identified in humans and other mammals. In fish STC is produced by one gland, circulates freely in the blood and plays an integral role in mineral homeostasis. In mammals, STC is produced in a number of diffe...