CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells

Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27-CD70 receptor-ligand interaction in Tregs is not clear. Here we show that after prolonged in vitro stimulation, a significa...

Full description

Saved in:
Bibliographic Details
Published inCommunications biology Vol. 3; no. 1; p. 375
Main Authors Arroyo Hornero, Rebeca, Georgiadis, Christos, Hua, Peng, Trzupek, Dominik, He, Li-Zhen, Qasim, Waseem, Todd, John A, Ferreira, Ricardo C, Wood, Kathryn J, Issa, Fadi, Hester, Joanna
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 14.07.2020
Nature Publishing Group UK
Subjects
Allergies
Animals
Autoimmunity
Biology
CD27 antigen
CD27 Ligand - genetics
CD27 Ligand - metabolism
CD70 antigen
Clonal deletion
CRISPR-Associated Protein 9
CRISPR-Cas Systems
Female
Flow Cytometry
Forkhead Transcription Factors - metabolism
Gene Editing
Gene Knockout Techniques
Homeostasis
Humans
Immunoregulation
Immunostimulation
Lymphocytes
Lymphocytes T
Mice, Inbred BALB C
Peripheral blood
Phenotypes
Ribonucleic acid
RNA
Sequence Analysis, RNA
T cell receptors
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
T-Lymphocytes, Regulatory - transplantation
Transcriptome
Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism
Online AccessGet full text

Cover

Abstract Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27-CD70 receptor-ligand interaction in Tregs is not clear. Here we show that after prolonged in vitro stimulation, a significant proportion of human Tregs gain stable CD70 expression while losing CD27. The expression of CD70 in expanded Tregs is associated with a profound loss of regulatory function and an unusual ability to provide CD70-directed co-stimulation to TCR-activated conventional T cells. Genetic deletion of CD70 or its blockade prevents Tregs from delivering this co-stimulatory signal, thus maintaining their regulatory activity. High resolution targeted single-cell RNA sequencing of human peripheral blood confirms the presence of CD27 CD70 Treg cells. These findings have important implications for Treg-based clinical studies where cells are expanded over extended periods in order to achieve sufficient treatment doses.
AbstractList Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27-CD70 receptor-ligand interaction in Tregs is not clear. Here we show that after prolonged in vitro stimulation, a significant proportion of human Tregs gain stable CD70 expression while losing CD27. The expression of CD70 in expanded Tregs is associated with a profound loss of regulatory function and an unusual ability to provide CD70-directed co-stimulation to TCR-activated conventional T cells. Genetic deletion of CD70 or its blockade prevents Tregs from delivering this co-stimulatory signal, thus maintaining their regulatory activity. High resolution targeted single-cell RNA sequencing of human peripheral blood confirms the presence of CD27 − CD70 + Treg cells. These findings have important implications for Treg-based clinical studies where cells are expanded over extended periods in order to achieve sufficient treatment doses. Regulatory T cells maintain immune homeostasis and help control development of autoimmunity and allergy. Arroyo-Hornero et al show that upon prolonged stimulation, regulatory T cells may switch to an immunostimulatory phenotype by upregulating the expression of the co-stimulatory molecule CD70.
Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27-CD70 receptor-ligand interaction in Tregs is not clear. Here we show that after prolonged in vitro stimulation, a significant proportion of human Tregs gain stable CD70 expression while losing CD27. The expression of CD70 in expanded Tregs is associated with a profound loss of regulatory function and an unusual ability to provide CD70-directed co-stimulation to TCR-activated conventional T cells. Genetic deletion of CD70 or its blockade prevents Tregs from delivering this co-stimulatory signal, thus maintaining their regulatory activity. High resolution targeted single-cell RNA sequencing of human peripheral blood confirms the presence of CD27 CD70 Treg cells. These findings have important implications for Treg-based clinical studies where cells are expanded over extended periods in order to achieve sufficient treatment doses.
Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27-CD70 receptor-ligand interaction in Tregs is not clear. Here we show that after prolonged in vitro stimulation, a significant proportion of human Tregs gain stable CD70 expression while losing CD27. The expression of CD70 in expanded Tregs is associated with a profound loss of regulatory function and an unusual ability to provide CD70-directed co-stimulation to TCR-activated conventional T cells. Genetic deletion of CD70 or its blockade prevents Tregs from delivering this co-stimulatory signal, thus maintaining their regulatory activity. High resolution targeted single-cell RNA sequencing of human peripheral blood confirms the presence of CD27-CD70+ Treg cells. These findings have important implications for Treg-based clinical studies where cells are expanded over extended periods in order to achieve sufficient treatment doses.Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27-CD70 receptor-ligand interaction in Tregs is not clear. Here we show that after prolonged in vitro stimulation, a significant proportion of human Tregs gain stable CD70 expression while losing CD27. The expression of CD70 in expanded Tregs is associated with a profound loss of regulatory function and an unusual ability to provide CD70-directed co-stimulation to TCR-activated conventional T cells. Genetic deletion of CD70 or its blockade prevents Tregs from delivering this co-stimulatory signal, thus maintaining their regulatory activity. High resolution targeted single-cell RNA sequencing of human peripheral blood confirms the presence of CD27-CD70+ Treg cells. These findings have important implications for Treg-based clinical studies where cells are expanded over extended periods in order to achieve sufficient treatment doses.
Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27-CD70 receptor-ligand interaction in Tregs is not clear. Here we show that after prolonged in vitro stimulation, a significant proportion of human Tregs gain stable CD70 expression while losing CD27. The expression of CD70 in expanded Tregs is associated with a profound loss of regulatory function and an unusual ability to provide CD70-directed co-stimulation to TCR-activated conventional T cells. Genetic deletion of CD70 or its blockade prevents Tregs from delivering this co-stimulatory signal, thus maintaining their regulatory activity. High resolution targeted single-cell RNA sequencing of human peripheral blood confirms the presence of CD27−CD70+ Treg cells. These findings have important implications for Treg-based clinical studies where cells are expanded over extended periods in order to achieve sufficient treatment doses.Regulatory T cells maintain immune homeostasis and help control development of autoimmunity and allergy. Arroyo-Hornero et al show that upon prolonged stimulation, regulatory T cells may switch to an immunostimulatory phenotype by upregulating the expression of the co-stimulatory molecule CD70.
Abstract Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27-CD70 receptor-ligand interaction in Tregs is not clear. Here we show that after prolonged in vitro stimulation, a significant proportion of human Tregs gain stable CD70 expression while losing CD27. The expression of CD70 in expanded Tregs is associated with a profound loss of regulatory function and an unusual ability to provide CD70-directed co-stimulation to TCR-activated conventional T cells. Genetic deletion of CD70 or its blockade prevents Tregs from delivering this co-stimulatory signal, thus maintaining their regulatory activity. High resolution targeted single-cell RNA sequencing of human peripheral blood confirms the presence of CD27 − CD70 + Treg cells. These findings have important implications for Treg-based clinical studies where cells are expanded over extended periods in order to achieve sufficient treatment doses.
ArticleNumber 375
Author Issa, Fadi
Arroyo Hornero, Rebeca
Wood, Kathryn J
Hua, Peng
Todd, John A
He, Li-Zhen
Hester, Joanna
Ferreira, Ricardo C
Georgiadis, Christos
Qasim, Waseem
Trzupek, Dominik
Author_xml – sequence: 1
  givenname: Rebeca
  orcidid: 0000-0001-7026-7358
  surname: Arroyo Hornero
  fullname: Arroyo Hornero, Rebeca
  organization: Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK
– sequence: 2
  givenname: Christos
  surname: Georgiadis
  fullname: Georgiadis, Christos
  organization: Molecular and Cellular Immunology Unit, UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK
– sequence: 3
  givenname: Peng
  orcidid: 0000-0003-3774-5033
  surname: Hua
  fullname: Hua, Peng
  organization: MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
– sequence: 4
  givenname: Dominik
  surname: Trzupek
  fullname: Trzupek, Dominik
  organization: JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK
– sequence: 5
  givenname: Li-Zhen
  surname: He
  fullname: He, Li-Zhen
  organization: Celldex Therapeutics, Inc., Hampton, NJ, 08827, USA
– sequence: 6
  givenname: Waseem
  surname: Qasim
  fullname: Qasim, Waseem
  organization: Molecular and Cellular Immunology Unit, UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK
– sequence: 7
  givenname: John A
  orcidid: 0000-0003-2740-8148
  surname: Todd
  fullname: Todd, John A
  organization: JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK
– sequence: 8
  givenname: Ricardo C
  surname: Ferreira
  fullname: Ferreira, Ricardo C
  organization: JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK
– sequence: 9
  givenname: Kathryn J
  surname: Wood
  fullname: Wood, Kathryn J
  organization: Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK
– sequence: 10
  givenname: Fadi
  orcidid: 0000-0002-8279-7732
  surname: Issa
  fullname: Issa, Fadi
  organization: Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK
– sequence: 11
  givenname: Joanna
  orcidid: 0000-0002-7466-3849
  surname: Hester
  fullname: Hester, Joanna
  email: joanna.hester@nds.ox.ac.uk
  organization: Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK. joanna.hester@nds.ox.ac.uk
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32665635$$D View this record in MEDLINE/PubMed
BookMark eNpdkU-L1TAUxYOMOH-cD-BGAm7cVG9y27TZCPJ0VBhwM4K7kCa38zq0yTNpB9-394U3DqOLcAP3nJMcfufsJMRAjL0S8E4Adu9zLQGwAgmVAN1W3TN2JlHrClUtT57cT9llzncAILTWCusX7BSlUo3C5oz93HxqgdPvXaKcxxi4p4XSPAbKfNlSOcnuaF1Gx2kYRmfdnsehOGzw5Pl2nW3giW7XyS4x7fkNdzRN-SV7Ptgp0-XDvGA_rj7fbL5W19-_fNt8vK5cLdulsoN1DntBGru66aRFKVvZOSHQ97oRFslTT-C1J6mcbKhvPIlWDL7xSgFesA_H3N3az-QdhSXZyezSONu0N9GO5t9NGLfmNt6bFhW0qjsEvH0ISPHXSnkx85hLBRsortnIWtaglcby1pv_pHdxTeFQr6hQNUJACRRHlUsx50TD42cEmILOHNGZAzpT0Jnief20xaPjLyj8A3pjly0
CitedBy_id crossref_primary_10_1016_j_cyto_2024_156585
crossref_primary_10_1016_j_ccell_2022_10_001
crossref_primary_10_1038_s42003_021_02721_x
crossref_primary_10_3389_fimmu_2023_1321228
crossref_primary_10_1007_s10875_021_01084_6
crossref_primary_10_1038_s41467_022_30613_z
crossref_primary_10_3389_fimmu_2021_686530
crossref_primary_10_3389_fimmu_2024_1383894
crossref_primary_10_3390_vaccines11020245
crossref_primary_10_1177_09636897221149444
crossref_primary_10_3389_fimmu_2023_1191866
crossref_primary_10_1016_j_eururo_2022_09_008
crossref_primary_10_1093_cei_uxac078
crossref_primary_10_1016_j_bbadis_2023_166849
crossref_primary_10_1016_j_clim_2022_109202
crossref_primary_10_3390_genes14030555
crossref_primary_10_1038_s42003_023_04777_3
crossref_primary_10_3389_fimmu_2022_781364
crossref_primary_10_1186_s13046_021_02215_y
crossref_primary_10_1038_s41467_024_47981_3
crossref_primary_10_1007_s00109_021_02116_9
crossref_primary_10_1200_PO_23_00544
crossref_primary_10_3389_fimmu_2021_649311
crossref_primary_10_3390_cancers14184532
crossref_primary_10_1016_j_omtm_2021_04_009
crossref_primary_10_1172_jci_insight_171844
crossref_primary_10_3389_fimmu_2024_1374763
crossref_primary_10_1016_j_jaut_2023_103057
crossref_primary_10_1016_j_it_2021_11_001
crossref_primary_10_3389_fimmu_2023_1165973
crossref_primary_10_1073_pnas_2205454119
crossref_primary_10_1038_s41467_023_37614_6
crossref_primary_10_1093_rheumatology_kead273
crossref_primary_10_1016_j_pharmthera_2021_108106
crossref_primary_10_1016_j_prp_2023_154709
crossref_primary_10_3389_fonc_2023_1240061
Cites_doi 10.1158/1078-0432.CCR-15-0263
10.1016/j.ejca.2005.05.005
10.1038/nri3650
10.4049/jimmunol.154.6.2612
10.1200/JCO.2016.70.1508
10.4049/jimmunol.174.3.1357
10.1002/eji.200737824
10.1084/jem.20160849
10.15252/embj.201490312
10.1084/jem.20060651
10.1158/1078-0432.CCR-12-2064
10.1158/0008-5472.CAN-12-4174
10.1016/j.immuni.2013.10.016
10.1038/83713
10.1016/j.omtm.2018.01.006
10.1084/jem.20030916
10.4049/jimmunol.1300409
10.1038/83784
10.1111/j.1365-2567.2006.02550.x
10.1056/NEJMoa1200694
10.1002/eji.201343751
10.1126/science.1169152
10.1084/jem.20060772
10.1038/ni.1774
10.1182/blood-2003-07-2375
10.1038/nri2526
10.1073/pnas.0900408106
10.1084/jem.20160784
10.1084/jem.20050085
10.4049/jimmunol.151.5.2426
10.1126/sciimmunol.aau2042
10.1186/s13059-015-0844-5
10.1038/nri1027
10.1172/JCI35834
10.1002/eji.200838904
10.1089/10430340252898984
10.1186/s40425-015-0080-2
10.1038/80877
10.1111/imr.12172
10.1111/j.1600-6143.2012.04065.x
10.4049/jimmunol.181.4.2855
10.1016/S1074-7613(01)00236-9
10.4049/jimmunol.170.1.33
10.3324/haematol.2012.068791
10.1053/j.gastro.2010.12.002
10.1016/j.cell.2019.05.031
10.1016/j.jaci.2011.11.013
10.1111/j.1600-065X.2009.00774.x
10.1084/jem.20060468
10.4049/jimmunol.0802809
10.1038/nature12198
10.1016/j.immuni.2009.03.019
10.1016/j.immuni.2017.10.009
10.1093/rheumatology/keu171
10.1182/blood-2005-07-3032
10.1016/j.jdermsci.2010.06.011
10.4049/jimmunol.145.5.1356
10.1182/blood-2012-08-443473
10.1016/j.immuni.2016.10.021
10.4049/jimmunol.1700380
10.3389/fimmu.2018.01103
10.1084/jem.20070176
10.1016/j.immuni.2018.04.008
10.1146/annurev.immunol.21.120601.141122
10.1002/ijc.10207
10.1016/j.immuni.2009.10.001
10.1097/TP.0000000000001278
10.1038/ncomms1948
10.4049/jimmunol.181.2.1071
10.1016/j.humimm.2015.12.004
10.1191/0961203305lu2171oa
10.1111/imr.12158
10.1016/j.coi.2005.04.004
10.1126/science.1079490
10.1016/j.ymthe.2018.02.025
10.1038/83707
10.1186/s13073-020-00756-z
10.1126/science.1160062
10.1097/00000478-200005000-00014
10.1016/j.immuni.2016.04.020
10.1016/j.jaci.2015.02.022
10.1038/jid.2011.139
10.1161/CIRCRESAHA.117.312340
10.1016/j.stem.2013.08.012
10.1084/jem.20112061
10.4049/jimmunol.180.1.214
10.1016/j.immuni.2008.05.007
10.1016/j.immuni.2016.02.022
10.1111/imr.12175
10.1038/nm.2154
10.1002/eji.200737594
10.1172/JCI72932
10.4049/jimmunol.0802424
10.1182/blood-2004-01-0086
10.1126/science.1191996
10.1073/pnas.1401343111
10.1111/imr.12173
ContentType Journal Article
Copyright The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2020
Copyright_xml – notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2020
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7XB
88I
8FE
8FH
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M2P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.1038/s42003-020-1097-8
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
ProQuest Central (purchase pre-March 2016)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
ProQuest Natural Science Collection
ProQuest One Community College
ProQuest Central
ProQuest Central Student
SciTech Premium Collection
Biological Sciences
ProQuest Science Journals
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Science Journals (Alumni Edition)
ProQuest Central Student
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Central Essentials
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
Biological Science Database
ProQuest SciTech Collection
ProQuest Central China
ProQuest Central
ProQuest One Academic UKI Edition
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
MEDLINE - Academic
Publicly Available Content Database
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2399-3642
ExternalDocumentID 10_1038_s42003_020_1097_8
32665635
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Wellcome Trust
– fundername: Medical Research Council
  grantid: MR/N027930/1
– fundername: Department of Health
  grantid: RP-2014-05-007
– fundername: Wellcome Trust
  grantid: 211122/Z/18/Z
– fundername: Wellcome Trust
  grantid: 107212/A/15/Z
– fundername: ;
– fundername: ;
  grantid: SF1/2014
GroupedDBID 0R~
53G
88I
AAADF
AAJSJ
ABDBF
ABUWG
ACGFS
ACSMW
ADBBV
AFGXO
AFKRA
AJTQC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BBNVY
BCNDV
BENPR
BHPHI
CCPQU
CGR
CUY
CVF
DWQXO
EBS
ECM
EIF
GNUQQ
GROUPED_DOAJ
HCIFZ
HYE
M2P
M7P
M~E
NAO
NPM
O9-
OK1
PIMPY
RNT
RPM
SNYQT
AAYXX
C6C
CITATION
EBLON
PGMZT
3V.
7XB
8FE
8FH
8FK
LK8
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c427t-afacc3b1e9384582a322728c113db951a3edebe0d9de26c25eb5de171fd5d6603
IEDL.DBID RPM
ISSN 2399-3642
IngestDate Tue Sep 17 21:14:20 EDT 2024
Tue Aug 27 04:29:48 EDT 2024
Sat Aug 31 00:12:11 EDT 2024
Fri Aug 23 00:56:04 EDT 2024
Thu May 23 23:26:50 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c427t-afacc3b1e9384582a322728c113db951a3edebe0d9de26c25eb5de171fd5d6603
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-7466-3849
0000-0003-2740-8148
0000-0001-7026-7358
0000-0002-8279-7732
0000-0003-3774-5033
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360768/
PMID 32665635
PQID 2423651108
PQPubID 4669726
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7360768
proquest_miscellaneous_2424096930
proquest_journals_2423651108
crossref_primary_10_1038_s42003_020_1097_8
pubmed_primary_32665635
PublicationCentury 2000
PublicationDate 2020-07-14
PublicationDateYYYYMMDD 2020-07-14
PublicationDate_xml – month: 07
  year: 2020
  text: 2020-07-14
  day: 14
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Communications biology
PublicationTitleAlternate Commun Biol
PublicationYear 2020
Publisher Nature Publishing Group
Nature Publishing Group UK
Publisher_xml – name: Nature Publishing Group
– name: Nature Publishing Group UK
References SL Bailey-Bucktrout (1097_CR70) 2013; 39
OK Alkhairy (1097_CR53) 2015; 136
AL Joly (1097_CR78) 2018; 122
HJ Bovenschen (1097_CR20) 2011; 131
SN Nadig (1097_CR60) 2010; 16
KP van Gisbergen (1097_CR80) 2009; 182
F Ramsdell (1097_CR6) 2014; 14
JM van Montfrans (1097_CR55) 2012; 129
CR Ruprecht (1097_CR59) 2005; 201
M Croft (1097_CR85) 2009; 9
P Hoffmann (1097_CR74) 2004; 104
R Arens (1097_CR48) 2001; 15
LZ He (1097_CR67) 2013; 191
HA Burris (1097_CR91) 2017; 35
BK Han (1097_CR40) 2005; 14
M Miyara (1097_CR66) 2009; 30
J Held-Feindt (1097_CR39) 2002; 98
YP Rubtsov (1097_CR17) 2010; 329
KS Voo (1097_CR25) 2009; 106
H Fraser (1097_CR73) 2018; 8
M Vukmanovic-Stejic (1097_CR71) 2008; 118
M Manocha (1097_CR43) 2009; 183
Z Hovhannisyan (1097_CR24) 2011; 140
A Yonezawa (1097_CR89) 2015; 21
M Tsuji (1097_CR16) 2009; 323
J Martorell (1097_CR30) 1990; 145
U Baron (1097_CR5) 2007; 37
JR Brahmer (1097_CR86) 2012; 366
TN Golovina (1097_CR27) 2008; 181
R Bhairavabhotla (1097_CR62) 2016; 77
RS Wildin (1097_CR9) 2001; 27
E Salzer (1097_CR54) 2013; 98
S Hori (1097_CR4) 2003; 299
C Demaison (1097_CR97) 2002; 13
A Yamada (1097_CR50) 2005; 174
H Soares (1097_CR45) 2007; 204
S Feau (1097_CR84) 2012; 3
S Latour (1097_CR51) 2018; 9
J Barbi (1097_CR12) 2014; 259
JJ Coenen (1097_CR58) 2006; 107
RQ Hintzen (1097_CR44) 1995; 154
RC Duggleby (1097_CR57) 2007; 121
A Ferraro (1097_CR65) 2014; 111
JM Coquet (1097_CR31) 2013; 210
V Ramakrishna (1097_CR64) 2015; 3
S Sakaguchi (1097_CR2) 2004; 22
J Diegmann (1097_CR38) 2005; 41
C Procaccini (1097_CR76) 2016; 44
S Hori (1097_CR14) 2014; 259
AM Pesenacker (1097_CR26) 2013; 121
K Tesselaar (1097_CR34) 2003; 170
FH Karlsson (1097_CR23) 2013; 498
P Hoffmann (1097_CR75) 2009; 39
JH Esensten (1097_CR87) 2016; 44
T Stuart (1097_CR94) 2019; 177
R Sanchez Rodriguez (1097_CR21) 2014; 124
E Cuadrado (1097_CR77) 2018; 48
K Wing (1097_CR28) 2008; 322
RE O’Neill (1097_CR81) 2017; 199
D Trzupek (1097_CR68) 2020; 12
M Matter (1097_CR79) 2006; 203
J Hester (1097_CR92) 2012; 12
M Dhainaut (1097_CR61) 2015; 34
CL Bennett (1097_CR7) 2001; 27
C Georgiadis (1097_CR96) 2018; 26
W Liu (1097_CR10) 2006; 203
A De Milito (1097_CR36) 2004; 103
J Hendriks (1097_CR49) 2003; 198
X Zhou (1097_CR15) 2009; 10
Y Xiao (1097_CR46) 2008; 181
M De Simone (1097_CR63) 2016; 45
R Arroyo Hornero (1097_CR72) 2017; 101
SP Singh (1097_CR69) 2008; 180
J Hendriks (1097_CR47) 2000; 1
T Hishima (1097_CR37) 2000; 24
H Yin (1097_CR41) 2010; 59
1097_CR22
KJ Wood (1097_CR3) 2003; 3
G Finak (1097_CR95) 2015; 16
MA Nolte (1097_CR32) 2009; 229
DV Sawant (1097_CR13) 2014; 259
J Borst (1097_CR35) 2005; 17
YD Mahnke (1097_CR33) 2013; 43
N Seddiki (1097_CR11) 2006; 203
BD Curti (1097_CR90) 2013; 73
JK Park (1097_CR42) 2014; 53
T Ahrends (1097_CR82) 2017; 47
G Oldenhove (1097_CR18) 2009; 31
IR Ferrer (1097_CR1) 2014; 258
K Izawa (1097_CR52) 2017; 214
MS Matter (1097_CR83) 2008; 38
XO Yang (1097_CR19) 2008; 29
RH Vonderheide (1097_CR88) 2013; 19
C Boiers (1097_CR93) 2013; 13
RQ Hintzen (1097_CR29) 1993; 151
H Abolhassani (1097_CR56) 2017; 214
ME Brunkow (1097_CR8) 2001; 27
References_xml – volume: 21
  start-page: 3113
  year: 2015
  ident: 1097_CR89
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-15-0263
  contributor:
    fullname: A Yonezawa
– volume: 41
  start-page: 1794
  year: 2005
  ident: 1097_CR38
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2005.05.005
  contributor:
    fullname: J Diegmann
– volume: 14
  start-page: 343
  year: 2014
  ident: 1097_CR6
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3650
  contributor:
    fullname: F Ramsdell
– volume: 154
  start-page: 2612
  year: 1995
  ident: 1097_CR44
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.154.6.2612
  contributor:
    fullname: RQ Hintzen
– volume: 35
  start-page: 2028
  year: 2017
  ident: 1097_CR91
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2016.70.1508
  contributor:
    fullname: HA Burris
– volume: 174
  start-page: 1357
  year: 2005
  ident: 1097_CR50
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.174.3.1357
  contributor:
    fullname: A Yamada
– volume: 38
  start-page: 1847
  year: 2008
  ident: 1097_CR83
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200737824
  contributor:
    fullname: MS Matter
– volume: 214
  start-page: 91
  year: 2017
  ident: 1097_CR56
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20160849
  contributor:
    fullname: H Abolhassani
– volume: 34
  start-page: 1336
  year: 2015
  ident: 1097_CR61
  publication-title: EMBO J.
  doi: 10.15252/embj.201490312
  contributor:
    fullname: M Dhainaut
– volume: 203
  start-page: 2145
  year: 2006
  ident: 1097_CR79
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20060651
  contributor:
    fullname: M Matter
– volume: 19
  start-page: 1035
  year: 2013
  ident: 1097_CR88
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-12-2064
  contributor:
    fullname: RH Vonderheide
– volume: 73
  start-page: 7189
  year: 2013
  ident: 1097_CR90
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-4174
  contributor:
    fullname: BD Curti
– volume: 39
  start-page: 949
  year: 2013
  ident: 1097_CR70
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.10.016
  contributor:
    fullname: SL Bailey-Bucktrout
– volume: 27
  start-page: 20
  year: 2001
  ident: 1097_CR7
  publication-title: Nat. Genet.
  doi: 10.1038/83713
  contributor:
    fullname: CL Bennett
– volume: 8
  start-page: 198
  year: 2018
  ident: 1097_CR73
  publication-title: Mol. Ther. Methods Clin. Dev.
  doi: 10.1016/j.omtm.2018.01.006
  contributor:
    fullname: H Fraser
– volume: 198
  start-page: 1369
  year: 2003
  ident: 1097_CR49
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20030916
  contributor:
    fullname: J Hendriks
– volume: 191
  start-page: 4174
  year: 2013
  ident: 1097_CR67
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1300409
  contributor:
    fullname: LZ He
– volume: 27
  start-page: 68
  year: 2001
  ident: 1097_CR8
  publication-title: Nat. Genet.
  doi: 10.1038/83784
  contributor:
    fullname: ME Brunkow
– volume: 121
  start-page: 129
  year: 2007
  ident: 1097_CR57
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2006.02550.x
  contributor:
    fullname: RC Duggleby
– volume: 366
  start-page: 2455
  year: 2012
  ident: 1097_CR86
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1200694
  contributor:
    fullname: JR Brahmer
– volume: 43
  start-page: 2797
  year: 2013
  ident: 1097_CR33
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201343751
  contributor:
    fullname: YD Mahnke
– volume: 323
  start-page: 1488
  year: 2009
  ident: 1097_CR16
  publication-title: Science
  doi: 10.1126/science.1169152
  contributor:
    fullname: M Tsuji
– volume: 203
  start-page: 1701
  year: 2006
  ident: 1097_CR10
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20060772
  contributor:
    fullname: W Liu
– volume: 10
  start-page: 1000
  year: 2009
  ident: 1097_CR15
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1774
  contributor:
    fullname: X Zhou
– volume: 103
  start-page: 2180
  year: 2004
  ident: 1097_CR36
  publication-title: Blood
  doi: 10.1182/blood-2003-07-2375
  contributor:
    fullname: A De Milito
– volume: 9
  start-page: 271
  year: 2009
  ident: 1097_CR85
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2526
  contributor:
    fullname: M Croft
– volume: 106
  start-page: 4793
  year: 2009
  ident: 1097_CR25
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0900408106
  contributor:
    fullname: KS Voo
– volume: 214
  start-page: 73
  year: 2017
  ident: 1097_CR52
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20160784
  contributor:
    fullname: K Izawa
– volume: 201
  start-page: 1793
  year: 2005
  ident: 1097_CR59
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20050085
  contributor:
    fullname: CR Ruprecht
– volume: 151
  start-page: 2426
  year: 1993
  ident: 1097_CR29
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.151.5.2426
  contributor:
    fullname: RQ Hintzen
– ident: 1097_CR22
  doi: 10.1126/sciimmunol.aau2042
– volume: 16
  year: 2015
  ident: 1097_CR95
  publication-title: Genome Biol.
  doi: 10.1186/s13059-015-0844-5
  contributor:
    fullname: G Finak
– volume: 3
  start-page: 199
  year: 2003
  ident: 1097_CR3
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri1027
  contributor:
    fullname: KJ Wood
– volume: 118
  start-page: 3639
  year: 2008
  ident: 1097_CR71
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI35834
  contributor:
    fullname: M Vukmanovic-Stejic
– volume: 39
  start-page: 1088
  year: 2009
  ident: 1097_CR75
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200838904
  contributor:
    fullname: P Hoffmann
– volume: 13
  start-page: 803
  year: 2002
  ident: 1097_CR97
  publication-title: Hum. Gene Ther.
  doi: 10.1089/10430340252898984
  contributor:
    fullname: C Demaison
– volume: 3
  start-page: 37
  year: 2015
  ident: 1097_CR64
  publication-title: J. Immunother. Cancer
  doi: 10.1186/s40425-015-0080-2
  contributor:
    fullname: V Ramakrishna
– volume: 1
  start-page: 433
  year: 2000
  ident: 1097_CR47
  publication-title: Nat. Immunol.
  doi: 10.1038/80877
  contributor:
    fullname: J Hendriks
– volume: 259
  start-page: 115
  year: 2014
  ident: 1097_CR12
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12172
  contributor:
    fullname: J Barbi
– volume: 12
  start-page: 2008
  year: 2012
  ident: 1097_CR92
  publication-title: Am. J. Transpl.
  doi: 10.1111/j.1600-6143.2012.04065.x
  contributor:
    fullname: J Hester
– volume: 181
  start-page: 2855
  year: 2008
  ident: 1097_CR27
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.181.4.2855
  contributor:
    fullname: TN Golovina
– volume: 15
  start-page: 801
  year: 2001
  ident: 1097_CR48
  publication-title: Immunity
  doi: 10.1016/S1074-7613(01)00236-9
  contributor:
    fullname: R Arens
– volume: 170
  start-page: 33
  year: 2003
  ident: 1097_CR34
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.170.1.33
  contributor:
    fullname: K Tesselaar
– volume: 98
  start-page: 473
  year: 2013
  ident: 1097_CR54
  publication-title: Haematologica
  doi: 10.3324/haematol.2012.068791
  contributor:
    fullname: E Salzer
– volume: 140
  start-page: 957
  year: 2011
  ident: 1097_CR24
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.12.002
  contributor:
    fullname: Z Hovhannisyan
– volume: 177
  start-page: 1888
  year: 2019
  ident: 1097_CR94
  publication-title: Cell
  doi: 10.1016/j.cell.2019.05.031
  contributor:
    fullname: T Stuart
– volume: 129
  start-page: 787
  year: 2012
  ident: 1097_CR55
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2011.11.013
  contributor:
    fullname: JM van Montfrans
– volume: 229
  start-page: 216
  year: 2009
  ident: 1097_CR32
  publication-title: Immunol. Rev.
  doi: 10.1111/j.1600-065X.2009.00774.x
  contributor:
    fullname: MA Nolte
– volume: 203
  start-page: 1693
  year: 2006
  ident: 1097_CR11
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20060468
  contributor:
    fullname: N Seddiki
– volume: 182
  start-page: 5352
  year: 2009
  ident: 1097_CR80
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0802809
  contributor:
    fullname: KP van Gisbergen
– volume: 498
  start-page: 99
  year: 2013
  ident: 1097_CR23
  publication-title: Nature
  doi: 10.1038/nature12198
  contributor:
    fullname: FH Karlsson
– volume: 30
  start-page: 899
  year: 2009
  ident: 1097_CR66
  publication-title: Immunity
  doi: 10.1016/j.immuni.2009.03.019
  contributor:
    fullname: M Miyara
– volume: 47
  start-page: 848
  year: 2017
  ident: 1097_CR82
  publication-title: Immunity
  doi: 10.1016/j.immuni.2017.10.009
  contributor:
    fullname: T Ahrends
– volume: 53
  start-page: 1896
  year: 2014
  ident: 1097_CR42
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/keu171
  contributor:
    fullname: JK Park
– volume: 107
  start-page: 1018
  year: 2006
  ident: 1097_CR58
  publication-title: Blood
  doi: 10.1182/blood-2005-07-3032
  contributor:
    fullname: JJ Coenen
– volume: 59
  start-page: 198
  year: 2010
  ident: 1097_CR41
  publication-title: J. Dermatol Sci.
  doi: 10.1016/j.jdermsci.2010.06.011
  contributor:
    fullname: H Yin
– volume: 145
  start-page: 1356
  year: 1990
  ident: 1097_CR30
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.145.5.1356
  contributor:
    fullname: J Martorell
– volume: 121
  start-page: 2647
  year: 2013
  ident: 1097_CR26
  publication-title: Blood
  doi: 10.1182/blood-2012-08-443473
  contributor:
    fullname: AM Pesenacker
– volume: 45
  start-page: 1135
  year: 2016
  ident: 1097_CR63
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.10.021
  contributor:
    fullname: M De Simone
– volume: 199
  start-page: 3700
  year: 2017
  ident: 1097_CR81
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1700380
  contributor:
    fullname: RE O’Neill
– volume: 9
  start-page: 1103
  year: 2018
  ident: 1097_CR51
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.01103
  contributor:
    fullname: S Latour
– volume: 204
  start-page: 1095
  year: 2007
  ident: 1097_CR45
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20070176
  contributor:
    fullname: H Soares
– volume: 48
  start-page: 1046
  year: 2018
  ident: 1097_CR77
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.04.008
  contributor:
    fullname: E Cuadrado
– volume: 22
  start-page: 531
  year: 2004
  ident: 1097_CR2
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.21.120601.141122
  contributor:
    fullname: S Sakaguchi
– volume: 98
  start-page: 352
  year: 2002
  ident: 1097_CR39
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.10207
  contributor:
    fullname: J Held-Feindt
– volume: 31
  start-page: 772
  year: 2009
  ident: 1097_CR18
  publication-title: Immunity
  doi: 10.1016/j.immuni.2009.10.001
  contributor:
    fullname: G Oldenhove
– volume: 101
  start-page: 302
  year: 2017
  ident: 1097_CR72
  publication-title: Transplantation
  doi: 10.1097/TP.0000000000001278
  contributor:
    fullname: R Arroyo Hornero
– volume: 3
  year: 2012
  ident: 1097_CR84
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms1948
  contributor:
    fullname: S Feau
– volume: 181
  start-page: 1071
  year: 2008
  ident: 1097_CR46
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.181.2.1071
  contributor:
    fullname: Y Xiao
– volume: 77
  start-page: 201
  year: 2016
  ident: 1097_CR62
  publication-title: Hum. Immunol.
  doi: 10.1016/j.humimm.2015.12.004
  contributor:
    fullname: R Bhairavabhotla
– volume: 14
  start-page: 598
  year: 2005
  ident: 1097_CR40
  publication-title: Lupus
  doi: 10.1191/0961203305lu2171oa
  contributor:
    fullname: BK Han
– volume: 258
  start-page: 102
  year: 2014
  ident: 1097_CR1
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12158
  contributor:
    fullname: IR Ferrer
– volume: 17
  start-page: 275
  year: 2005
  ident: 1097_CR35
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2005.04.004
  contributor:
    fullname: J Borst
– volume: 299
  start-page: 1057
  year: 2003
  ident: 1097_CR4
  publication-title: Science
  doi: 10.1126/science.1079490
  contributor:
    fullname: S Hori
– volume: 26
  start-page: 1215
  year: 2018
  ident: 1097_CR96
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2018.02.025
  contributor:
    fullname: C Georgiadis
– volume: 27
  start-page: 18
  year: 2001
  ident: 1097_CR9
  publication-title: Nat. Genet.
  doi: 10.1038/83707
  contributor:
    fullname: RS Wildin
– volume: 12
  start-page: 55
  year: 2020
  ident: 1097_CR68
  publication-title: Genome Medicine
  doi: 10.1186/s13073-020-00756-z
  contributor:
    fullname: D Trzupek
– volume: 322
  start-page: 271
  year: 2008
  ident: 1097_CR28
  publication-title: Science
  doi: 10.1126/science.1160062
  contributor:
    fullname: K Wing
– volume: 24
  start-page: 742
  year: 2000
  ident: 1097_CR37
  publication-title: Am. J. Surg. Pathol.
  doi: 10.1097/00000478-200005000-00014
  contributor:
    fullname: T Hishima
– volume: 44
  start-page: 973
  year: 2016
  ident: 1097_CR87
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.04.020
  contributor:
    fullname: JH Esensten
– volume: 136
  start-page: 703
  year: 2015
  ident: 1097_CR53
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2015.02.022
  contributor:
    fullname: OK Alkhairy
– volume: 131
  start-page: 1853
  year: 2011
  ident: 1097_CR20
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2011.139
  contributor:
    fullname: HJ Bovenschen
– volume: 122
  start-page: 1385
  year: 2018
  ident: 1097_CR78
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.117.312340
  contributor:
    fullname: AL Joly
– volume: 13
  start-page: 535
  year: 2013
  ident: 1097_CR93
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.08.012
  contributor:
    fullname: C Boiers
– volume: 210
  start-page: 715
  year: 2013
  ident: 1097_CR31
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20112061
  contributor:
    fullname: JM Coquet
– volume: 180
  start-page: 214
  year: 2008
  ident: 1097_CR69
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.180.1.214
  contributor:
    fullname: SP Singh
– volume: 29
  start-page: 44
  year: 2008
  ident: 1097_CR19
  publication-title: Immunity
  doi: 10.1016/j.immuni.2008.05.007
  contributor:
    fullname: XO Yang
– volume: 44
  start-page: 712
  year: 2016
  ident: 1097_CR76
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.02.022
  contributor:
    fullname: C Procaccini
– volume: 259
  start-page: 159
  year: 2014
  ident: 1097_CR14
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12175
  contributor:
    fullname: S Hori
– volume: 16
  start-page: 809
  year: 2010
  ident: 1097_CR60
  publication-title: Nat. Med.
  doi: 10.1038/nm.2154
  contributor:
    fullname: SN Nadig
– volume: 37
  start-page: 2378
  year: 2007
  ident: 1097_CR5
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200737594
  contributor:
    fullname: U Baron
– volume: 124
  start-page: 1027
  year: 2014
  ident: 1097_CR21
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI72932
  contributor:
    fullname: R Sanchez Rodriguez
– volume: 183
  start-page: 270
  year: 2009
  ident: 1097_CR43
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0802424
  contributor:
    fullname: M Manocha
– volume: 104
  start-page: 895
  year: 2004
  ident: 1097_CR74
  publication-title: Blood
  doi: 10.1182/blood-2004-01-0086
  contributor:
    fullname: P Hoffmann
– volume: 329
  start-page: 1667
  year: 2010
  ident: 1097_CR17
  publication-title: Science
  doi: 10.1126/science.1191996
  contributor:
    fullname: YP Rubtsov
– volume: 111
  start-page: E1111
  year: 2014
  ident: 1097_CR65
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1401343111
  contributor:
    fullname: A Ferraro
– volume: 259
  start-page: 173
  year: 2014
  ident: 1097_CR13
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12173
  contributor:
    fullname: DV Sawant
SSID ssj0001999634
Score 2.3583739
Snippet Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs, although the...
Abstract Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory molecule CD27 is a marker of highly suppressive Tregs,...
SourceID pubmedcentral
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 375
SubjectTerms Allergies
Animals
Autoimmunity
Biology
CD27 antigen
CD27 Ligand - genetics
CD27 Ligand - metabolism
CD70 antigen
Clonal deletion
CRISPR-Associated Protein 9
CRISPR-Cas Systems
Female
Flow Cytometry
Forkhead Transcription Factors - metabolism
Gene Editing
Gene Knockout Techniques
Homeostasis
Humans
Immunoregulation
Immunostimulation
Lymphocytes
Lymphocytes T
Mice, Inbred BALB C
Peripheral blood
Phenotypes
Ribonucleic acid
RNA
Sequence Analysis, RNA
T cell receptors
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
T-Lymphocytes, Regulatory - transplantation
Transcriptome
Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ZS8QwEB48EHwRb-tFBJ-EsG3THH0STxZBEVHYt5I0KfrSrrsruP_eTI_VVfA5KW1ncnyZbzIfwGlacM2YUFRz62iiWUiNEhHlVloTpkUs60pM9w-i_5LcDfhgAfrdXRhMq-zWxHqhtlWOMfIe7vuCY9J6TxuMAuST3vnwnaJ-FPKsrZjGIizHUYKE7fLlzcPj03e8BZE9Szpik6neOKkTs_D8hDQsVfNb0x-8-Ttt8sc-dLsOay2AJBeNxzdgwZWbsNJISk63YHB1LUPiPtv81pLYNt_FjYnHeuTHfSvisHyEzqekKvAJDCdbUov2kVEjUV-NpuSZYHB_vA0vtzfPV33aqifQPInlhOpC5zkzkUuZQnJM-6krY5VHEbPG4yrNnPUeDG1qXSzymDvj3RXJqLDcChGyHVgqq9LtAYkjw7FQTFEgwLMyDcPCJPXhyimRigDOOsNlw6ZIRlaT20xljZUzb-WG7FYBHHamzdr5Ms6-vRvAyazZj3T8Q1266qPu4w-jKN0YwG7jidnbPAj1wJTxAOScj2YdsIr2fEv59lpX05ZMIBu5__9nHcBqjCMFS2omh7A0GX24Iw9HJua4HWlfW9vgUg
  priority: 102
  providerName: ProQuest
Title CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells
URI https://www.ncbi.nlm.nih.gov/pubmed/32665635
https://www.proquest.com/docview/2423651108/abstract/
https://www.proquest.com/docview/2424096930/abstract/
https://pubmed.ncbi.nlm.nih.gov/PMC7360768
Volume 3
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS8MwED_8QPBF_LY6RwSfhLq2aZL2cU5FBor4AXsrSZPiQDvZJrj_3lzajk3ffOpDEtreXcjvcr-7AzhPCyYp5YkvmTZ-LGngq4SHPtNCqyAtIuEqMd0_8LvXuD9ggxVgTS6MI-3nanhZvn9clsM3x638_Mg7DU-s83jfE5RjAKmzCquC0gUX3V2sIISncRPBpElnEjsGFjpKGG_1sUefRS0WybgmbwvH0R-M-ZsquXD23G7DVg0aSbf6uB1YMeUubFRtJGd7MOhdi4CY75rTWhJdc1zMhFh8RxZyrIjBkhEyn5FRgSvwClkT16iPjKu29KPxjLwQvNCf7MPr7c1L786vOyb4eRyJqS8LmedUhSalCQbEpN2uIkryMKRaWSwlqdFWa4FOtYl4HjGjrIpCERaaac4DegBr5ag0R0CiUDEsDlMUCOq0SIOgULFzqEzCU-7BRSO47LMqjJG5gDZNskrgmRV4FeBOPGg1os3qPTLJEMlxhmkIHpzNh6114x_K0oy-3BzrgGK7Rg8OK03M39ao0AOxpKP5BKycvTxiDcpV0K4N6PjfK09gM0J7wgqbcQvWpuMvc2rRyVS1Yb3b7T_37fPq5uHxqe28_Laz0R-HNeho
link.rule.ids 230,315,733,786,790,870,891,21416,27957,27958,33779,33780,43840,53827,53829
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1JT9tAFH6iQai9IJYuLoEOEqdKI2yPZ_EJQQClLBGqgpSbNfaMRS82xEEi_77z7EkgrcTZY9l-b5bvLf4-gKO05JoxoajmxtJEs5DmSkSUG2nyMC1j2TIx3Y7E8D65mvCJT7g1vq1ysSe2G7WpC8yRH-O5Lzg2rZ88PlFUjcLqqpfQ-ADrCXOhSg_Wzy5Gd79fsyyI51myKGcyddwkbTsWRk1YfKVq9UD6D2X-2yz55vS53IJNDxvJaefnbViz1Q5sdEKS812YDM5lSOyL72qtiPFdLrYhDuGRN39ZEYukEbqYk7rEOzCJbEgr1UemnTB9PZ2TMcGUfvMZ7i8vxoMh9ZoJtEhiOaO61EXB8simzh5cxdotWBmrIoqYyR2a0swa57fQpMbGooi5zZ2TIhmVhhshQvYFelVd2W9A4ijnSA9TlgjrjEzDsMyTNqSySqQigJ8Lw2WPHTVG1pa0mco6K2fOyl2JWwXQX5g286ukyV59GsDh8rKb3_iFurL1czvGhaAo2BjA184Ty6c56OngKOMByBUfLQcgd_bqlerPQ8uhLZnAGuT391_rB3wcjm9vsptfo-s9-BTjrEFSzaQPvdn02e47QDLLD_ys-wsyS9-F
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LTtwwFL1qqVqxgdIHhNLiSl1VyuThxE6W1cCIPkAsQBp1E_mpIiAzmofE8PX4Osko0B1rO0qsex0f-x6fA_CttLmglBWhyLUJM0HjUBYsCXPNtYxLm3KvxHR6xk4us1_jfNyz-vKkfSWvBvXN7aC--ue5ldNbFXU8sej8dMgpwwJSNNU2egmv3JxNy95G3R-vIJCnWVfHpEU0zzwPC7dLWHUN0anPYReHZ7zVW29R-g9pPiVM9lag0Tb87b69IZ5cD5YLOVD3T2QdnzW4t7DV4lLyo-myAy9M_Q5eN06Vq_cwHh7xmJi7ljZbE93SaMycOAhJete4iEFVCqFWZGLxCTyl1sR7AZJZ43w_ma3IBcGawfwDXI6OL4YnYWvKEKos5YtQWKEUlYkpaYE1N-H-CDwtVJJQLR1cE9RolxixLrVJmUpzI10WJDyxOteMxfQjbNST2uwBSROZo_6MtYgbNS_j2MrM79lMwUoWwPcuKtW00d6ofM2cFlUTzcpFs6mhFwEcdHGr2mk4rxAsshxvOgTwdd3sJhCOUNRmsvR93B4XHSED2G3CvH5blx8B8EcJsO6A4tyPW1xYvUh3G8b9Zz95CG_Oj0bVn59nvz_BZop5i3qe2QFsLGZL89lhoYX84rP-AUIMCNk
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CD70+expression+determines+the+therapeutic+efficacy+of+expanded+human+regulatory+T+cells&rft.jtitle=Communications+biology&rft.au=Arroyo%2C+Hornero+Rebeca&rft.au=Georgiadis+Christos&rft.au=Peng%2C+Hua&rft.au=Trzupek+Dominik&rft.date=2020-07-14&rft.pub=Nature+Publishing+Group&rft.eissn=2399-3642&rft.volume=3&rft.issue=1&rft_id=info:doi/10.1038%2Fs42003-020-1097-8
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2399-3642&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2399-3642&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2399-3642&client=summon