RNA-Seq transcriptomics and pathway analyses reveal potential regulatory genes and molecular mechanisms in high- and low-residual feed intake in Nordic dairy cattle

• Published in: BMC genomics Vol. 18; no. 1; p. 258
• Main Authors: Salleh, M S, Mazzoni, G, Höglund, J K, Olijhoek, D W, Lund, P, Løvendahl, P, Kadarmideen, H N
• Format: Journal Article
• Language: English
• Published: England BioMed Central 24.03.2017
• Subjects: Animal Feed; Animal husbandry; Animal lactation; Animal Nutritional Physiological Phenomena; Animals; Arachidonic acid; Biomarkers; Biosynthesis; Breeding; Cattle; Cattle feeds; Chromosome Mapping; Cluster Analysis; Cytochrome P450; Cytochromes P450; Dairy cattle; Diet; Drug metabolism; Efficiency; Feed conversion; Feed efficiency; Feeds; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Gene sequencing; Genes; Genes, Regulator; Genomes; Genomics; High-Throughput Nucleotide Sequencing; Immunodeficiency; Lipid metabolism; Lipids; Liver; Liver - metabolism; Metabolic disorders; Milk; Molecular modelling; Primary immunodeficiencies; Profits; Ribonucleic acid; RNA; Selective breeding; Signal Transduction; Starch; Steroids; Studies; Sucrose; Sugar; Transcriptome; Transcriptomics; Vitamin A; Differentially expressed genes; Residual feed intake; Pathways; Feed efficiency; RNA-Seq; Dairy cattle

The selective breeding of cattle with high-feed efficiencies (FE) is an important goal of beef and dairy cattle producers. Global gene expression patterns in relevant tissues can be used to study the functions of genes that are potentially involved in regulating FE. In the present study, high-throug...