Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects

• Published in: Psychological medicine Vol. 52; no. 6; pp. 1069 - 1079
• Main Authors: Nenadić, Igor, Meller, Tina, Schmitt, Simon, Stein, Frederike, Brosch, Katharina, Mosebach, Johannes, Ettinger, Ulrich, Grant, Phillip, Meinert, Susanne, Opel, Nils, Lemke, Hannah, Fingas, Stella, Förster, Katharina, Hahn, Tim, Jansen, Andreas, Andlauer, Till F. M., Forstner, Andreas J., Heilmann-Heimbach, Stefanie, Hall, Alisha S. M., Awasthi, Swapnil, Ripke, Stephan, Witt, Stephanie H., Rietschel, Marcella, Müller-Myhsok, Bertram, Nöthen, Markus M., Dannlowski, Udo, Krug, Axel, Streit, Fabian, Kircher, Tilo
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.04.2022
• Subjects: Affective disorders; Bipolar Disorder; Blood & organ donations; Blood donors; Donors; Emotional disorders; Genetic susceptibility; Genomes; Genotype & phenotype; Hallucinations; Humans; Mental disorders; Multicenter studies; Original Article; Personality disorders; Phenotype; Phenotypes; Polygenic inheritance; Population; Psychosis; Psychotic Disorders - psychology; Quantitative psychology; Questionnaires; Schizophrenia; Schizophrenia - genetics; Schizotypal personality; Schizotypal personality disorder; Schizotypal Personality Disorder - psychology; major depressive disorder; Bipolar disorder; depression; schizophrenia; schizotypy; psychosis proneness; psychosis

Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood. We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in...