Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects

Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood. We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in...

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Published inPsychological medicine Vol. 52; no. 6; pp. 1069 - 1079
Main Authors Nenadić, Igor, Meller, Tina, Schmitt, Simon, Stein, Frederike, Brosch, Katharina, Mosebach, Johannes, Ettinger, Ulrich, Grant, Phillip, Meinert, Susanne, Opel, Nils, Lemke, Hannah, Fingas, Stella, Förster, Katharina, Hahn, Tim, Jansen, Andreas, Andlauer, Till F. M., Forstner, Andreas J., Heilmann-Heimbach, Stefanie, Hall, Alisha S. M., Awasthi, Swapnil, Ripke, Stephan, Witt, Stephanie H., Rietschel, Marcella, Müller-Myhsok, Bertram, Nöthen, Markus M., Dannlowski, Udo, Krug, Axel, Streit, Fabian, Kircher, Tilo
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 01.04.2022
Subjects
Affective disorders
Bipolar Disorder
Blood & organ donations
Blood donors
Donors
Emotional disorders
Genetic susceptibility
Genomes
Genotype & phenotype
Hallucinations
Humans
Mental disorders
Multicenter studies
Original Article
Personality disorders
Phenotype
Phenotypes
Polygenic inheritance
Population
Psychosis
Psychotic Disorders - psychology
Quantitative psychology
Questionnaires
Schizophrenia
Schizophrenia - genetics
Schizotypal personality
Schizotypal personality disorder
Schizotypal Personality Disorder - psychology
major depressive disorder
Bipolar disorder
depression
schizophrenia
schizotypy
psychosis proneness
psychosis
Online AccessGet full text
ISSN0033-2917
1469-8978
1469-8978
DOI10.1017/S0033291720002822

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Abstract Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood. We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors. We did not find correlations of schizophrenia PRS with either overall SPQ or specific dimension scores, nor with adjusted schizotypy scores derived from the SPQ (addressing inter-scale variance). Also, PRS for affective disorders (bipolar disorder and major depression) were not significantly associated with schizotypy. This important negative finding demonstrates that despite the hypothesised continuum of schizotypy and schizophrenia, schizotypy might share less genetic risk with schizophrenia than previously assumed (and possibly less compared to psychotic-like experiences).
AbstractList Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood.BACKGROUNDSchizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood.We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors.METHODSWe tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors.We did not find correlations of schizophrenia PRS with either overall SPQ or specific dimension scores, nor with adjusted schizotypy scores derived from the SPQ (addressing inter-scale variance). Also, PRS for affective disorders (bipolar disorder and major depression) were not significantly associated with schizotypy.RESULTSWe did not find correlations of schizophrenia PRS with either overall SPQ or specific dimension scores, nor with adjusted schizotypy scores derived from the SPQ (addressing inter-scale variance). Also, PRS for affective disorders (bipolar disorder and major depression) were not significantly associated with schizotypy.This important negative finding demonstrates that despite the hypothesised continuum of schizotypy and schizophrenia, schizotypy might share less genetic risk with schizophrenia than previously assumed (and possibly less compared to psychotic-like experiences).CONCLUSIONSThis important negative finding demonstrates that despite the hypothesised continuum of schizotypy and schizophrenia, schizotypy might share less genetic risk with schizophrenia than previously assumed (and possibly less compared to psychotic-like experiences).
Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood. We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors. We did not find correlations of schizophrenia PRS with either overall SPQ or specific dimension scores, nor with adjusted schizotypy scores derived from the SPQ (addressing inter-scale variance). Also, PRS for affective disorders (bipolar disorder and major depression) were not significantly associated with schizotypy. This important negative finding demonstrates that despite the hypothesised continuum of schizotypy and schizophrenia, schizotypy might share less genetic risk with schizophrenia than previously assumed (and possibly less compared to psychotic-like experiences).
BackgroundSchizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood.MethodsWe tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors.ResultsWe did not find correlations of schizophrenia PRS with either overall SPQ or specific dimension scores, nor with adjusted schizotypy scores derived from the SPQ (addressing inter-scale variance). Also, PRS for affective disorders (bipolar disorder and major depression) were not significantly associated with schizotypy.ConclusionsThis important negative finding demonstrates that despite the hypothesised continuum of schizotypy and schizophrenia, schizotypy might share less genetic risk with schizophrenia than previously assumed (and possibly less compared to psychotic-like experiences).
Author Forstner, Andreas J.
Meller, Tina
Heilmann-Heimbach, Stefanie
Ettinger, Ulrich
Hall, Alisha S. M.
Krug, Axel
Stein, Frederike
Grant, Phillip
Witt, Stephanie H.
Hahn, Tim
Streit, Fabian
Andlauer, Till F. M.
Meinert, Susanne
Ripke, Stephan
Brosch, Katharina
Rietschel, Marcella
Mosebach, Johannes
Müller-Myhsok, Bertram
Nenadić, Igor
Jansen, Andreas
Fingas, Stella
Awasthi, Swapnil
Opel, Nils
Lemke, Hannah
Dannlowski, Udo
Schmitt, Simon
Kircher, Tilo
Nöthen, Markus M.
Förster, Katharina
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32758327$$D View this record in MEDLINE/PubMed
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Keywords major depressive disorder
Bipolar disorder
depression
schizophrenia
schizotypy
psychosis proneness
psychosis
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Snippet Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood. We tested...
BackgroundSchizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly...
Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly...
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crossref
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StartPage 1069
SubjectTerms Affective disorders
Bipolar Disorder
Blood & organ donations
Blood donors
Donors
Emotional disorders
Genetic susceptibility
Genomes
Genotype & phenotype
Hallucinations
Humans
Mental disorders
Multicenter studies
Original Article
Personality disorders
Phenotype
Phenotypes
Polygenic inheritance
Population
Psychosis
Psychotic Disorders - psychology
Quantitative psychology
Questionnaires
Schizophrenia
Schizophrenia - genetics
Schizotypal personality
Schizotypal personality disorder
Schizotypal Personality Disorder - psychology
Title Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects
URI https://www.cambridge.org/core/product/identifier/S0033291720002822/type/journal_article
https://www.ncbi.nlm.nih.gov/pubmed/32758327
https://www.proquest.com/docview/2673461690
https://www.proquest.com/docview/2431812574
Volume 52
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