Generating favorable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment

[Display omitted] Tissue engineering (particularly for the case of load-bearing cardiovascular and connective tissues) requires the ability to promote the production and accumulation of extracellular matrix (ECM) components (e.g., collagen, glycosaminoglycan and elastin). Although different approach...

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Published inActa biomaterialia Vol. 54; pp. 81 - 94
Main Authors Zhang, Xiaoqing, Battiston, Kyle G., Labow, Rosalind S., Simmons, Craig A., Santerre, J. Paul
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.05.2017
Elsevier BV
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Abstract [Display omitted] Tissue engineering (particularly for the case of load-bearing cardiovascular and connective tissues) requires the ability to promote the production and accumulation of extracellular matrix (ECM) components (e.g., collagen, glycosaminoglycan and elastin). Although different approaches have been attempted in order to enhance ECM accumulation in tissue engineered constructs, studies of underlying signalling mechanisms that influence ECM deposition and degradation during tissue remodelling and regeneration in multi-cellular culture systems have been limited. The current study investigated vascular smooth muscle cell (VSMC)-monocyte co-culture systems using different VSMC:monocyte ratios, within a degradable polyurethane scaffold, to assess their influence on ECM generation and degradation processes, and to elucidate relevant signalling molecules involved in this in vitro vascular tissue engineering system. It was found that a desired release profile of growth factors (e.g. insulin growth factor-1 (IGF-1)) and hydrolytic proteases (e.g. matrix-metalloproteinases 2, 9, 13 and 14 (MMP2, MMP9, MMP13 and MMP14)), could be achieved in co-culture systems, yielding an accumulation of ECM (specifically for 2:1 and 4:1 VSMC:monocyte culture systems). This study has significant implications for the tissue engineering field (including vascular tissue engineering), not only because it identified important cytokines and proteases that control ECM accumulation/degradation within synthetic tissue engineering scaffolds, but also because the established culture systems could be applied to improve the development of different types of tissue constructs. Sufficient extracellular matrix accumulation within cardiovascular and connective tissue engineered constructs is a prerequisite for their appropriate function in vivo. This study established co-culture systems with tissue specific cells (vascular smooth muscle cells (VSMCs)) and defined ratios of immune cells (monocytes) to investigate extracellular matrix (ECM) generation and degradation processes, revealing important mechanisms underlying ECM turnover during vascular tissue regeneration/remodelling. A specific growth factor (IGF-1), as well as hydrolytic proteases (e.g. MMP2, MMP9, MMP13 and MMP14), were identified as playing important roles in these processes. ECM accumulation was found to be dependent on achieving a desired release profile of these ECM-promoting and ECM-degrading factors within the multi-cellular microenvironment. The findings enhance our understanding of ECM deposition and degradation during in vitro tissue engineering and would be applicable to the repair or regeneration of a variety of tissues.
AbstractList Tissue engineering (particularly for the case of load-bearing cardiovascular and connective tissues) requires the ability to promote the production and accumulation of extracellular matrix (ECM) components (e.g., collagen, glycosaminoglycan and elastin). Although different approaches have been attempted in order to enhance ECM accumulation in tissue engineered constructs, studies of underlying signalling mechanisms that influence ECM deposition and degradation during tissue remodelling and regeneration in multi-cellular culture systems have been limited. The current study investigated vascular smooth muscle cell (VSMC)-monocyte co-culture systems using different VSMC:monocyte ratios, within a degradable polyurethane scaffold, to assess their influence on ECM generation and degradation processes, and to elucidate relevant signalling molecules involved in this in vitro vascular tissue engineering system. It was found that a desired release profile of growth factors (e.g. insulin growth factor-1 (IGF-1)) and hydrolytic proteases (e.g. matrix-metalloproteinases 2, 9, 13 and 14 (MMP2, MMP9, MMP13 and MMP14)), could be achieved in co-culture systems, yielding an accumulation of ECM (specifically for 2:1 and 4:1 VSMC:monocyte culture systems). This study has significant implications for the tissue engineering field (including vascular tissue engineering), not only because it identified important cytokines and proteases that control ECM accumulation/degradation within synthetic tissue engineering scaffolds, but also because the established culture systems could be applied to improve the development of different types of tissue constructs. Sufficient extracellular matrix accumulation within cardiovascular and connective tissue engineered constructs is a prerequisite for their appropriate function in vivo. This study established co-culture systems with tissue specific cells (vascular smooth muscle cells (VSMCs)) and defined ratios of immune cells (monocytes) to investigate extracellular matrix (ECM) generation and degradation processes, revealing important mechanisms underlying ECM turnover during vascular tissue regeneration/remodelling. A specific growth factor (IGF-1), as well as hydrolytic proteases (e.g. MMP2, MMP9, MMP13 and MMP14), were identified as playing important roles in these processes. ECM accumulation was found to be dependent on achieving a desired release profile of these ECM-promoting and ECM-degrading factors within the multi-cellular microenvironment. The findings enhance our understanding of ECM deposition and degradation during in vitro tissue engineering and would be applicable to the repair or regeneration of a variety of tissues.
[Display omitted] Tissue engineering (particularly for the case of load-bearing cardiovascular and connective tissues) requires the ability to promote the production and accumulation of extracellular matrix (ECM) components (e.g., collagen, glycosaminoglycan and elastin). Although different approaches have been attempted in order to enhance ECM accumulation in tissue engineered constructs, studies of underlying signalling mechanisms that influence ECM deposition and degradation during tissue remodelling and regeneration in multi-cellular culture systems have been limited. The current study investigated vascular smooth muscle cell (VSMC)-monocyte co-culture systems using different VSMC:monocyte ratios, within a degradable polyurethane scaffold, to assess their influence on ECM generation and degradation processes, and to elucidate relevant signalling molecules involved in this in vitro vascular tissue engineering system. It was found that a desired release profile of growth factors (e.g. insulin growth factor-1 (IGF-1)) and hydrolytic proteases (e.g. matrix-metalloproteinases 2, 9, 13 and 14 (MMP2, MMP9, MMP13 and MMP14)), could be achieved in co-culture systems, yielding an accumulation of ECM (specifically for 2:1 and 4:1 VSMC:monocyte culture systems). This study has significant implications for the tissue engineering field (including vascular tissue engineering), not only because it identified important cytokines and proteases that control ECM accumulation/degradation within synthetic tissue engineering scaffolds, but also because the established culture systems could be applied to improve the development of different types of tissue constructs. Sufficient extracellular matrix accumulation within cardiovascular and connective tissue engineered constructs is a prerequisite for their appropriate function in vivo. This study established co-culture systems with tissue specific cells (vascular smooth muscle cells (VSMCs)) and defined ratios of immune cells (monocytes) to investigate extracellular matrix (ECM) generation and degradation processes, revealing important mechanisms underlying ECM turnover during vascular tissue regeneration/remodelling. A specific growth factor (IGF-1), as well as hydrolytic proteases (e.g. MMP2, MMP9, MMP13 and MMP14), were identified as playing important roles in these processes. ECM accumulation was found to be dependent on achieving a desired release profile of these ECM-promoting and ECM-degrading factors within the multi-cellular microenvironment. The findings enhance our understanding of ECM deposition and degradation during in vitro tissue engineering and would be applicable to the repair or regeneration of a variety of tissues.
Tissue engineering (particularly for the case of load-bearing cardiovascular and connective tissues) requires the ability to promote the production and accumulation of extracellular matrix (ECM) components (e.g., collagen, glycosaminoglycan and elastin). Although different approaches have been attempted in order to enhance ECM accumulation in tissue engineered constructs, studies of underlying signalling mechanisms that influence ECM deposition and degradation during tissue remodelling and regeneration in multi-cellular culture systems have been limited. The current study investigated vascular smooth muscle cell (VSMC)-monocyte co-culture systems using different VSMC:monocyte ratios, within a degradable polyurethane scaffold, to assess their influence on ECM generation and degradation processes, and to elucidate relevant signalling molecules involved in this in vitro vascular tissue engineering system. It was found that a desired release profile of growth factors (e.g. insulin growth factor-1 (IGF-1)) and hydrolytic proteases (e.g. matrix-metalloproteinases 2, 9, 13 and 14 (MMP2, MMP9, MMP13 and MMP14)), could be achieved in co-culture systems, yielding an accumulation of ECM (specifically for 2:1 and 4:1 VSMC:monocyte culture systems). This study has significant implications for the tissue engineering field (including vascular tissue engineering), not only because it identified important cytokines and proteases that control ECM accumulation/degradation within synthetic tissue engineering scaffolds, but also because the established culture systems could be applied to improve the development of different types of tissue constructs.STATEMENT OF SIGNIFICANCESufficient extracellular matrix accumulation within cardiovascular and connective tissue engineered constructs is a prerequisite for their appropriate function in vivo. This study established co-culture systems with tissue specific cells (vascular smooth muscle cells (VSMCs)) and defined ratios of immune cells (monocytes) to investigate extracellular matrix (ECM) generation and degradation processes, revealing important mechanisms underlying ECM turnover during vascular tissue regeneration/remodelling. A specific growth factor (IGF-1), as well as hydrolytic proteases (e.g. MMP2, MMP9, MMP13 and MMP14), were identified as playing important roles in these processes. ECM accumulation was found to be dependent on achieving a desired release profile of these ECM-promoting and ECM-degrading factors within the multi-cellular microenvironment. The findings enhance our understanding of ECM deposition and degradation during in vitro tissue engineering and would be applicable to the repair or regeneration of a variety of tissues.
Tissue engineering (particularly for the case of load-bearing cardiovascular and connective tissues) requires the ability to promote the production and accumulation of extracellular matrix (ECM) components (e.g., collagen, glycosaminoglycan and elastin). Although different approaches have been attempted in order to enhance ECM accumulation in tissue engineered constructs, studies of underlying signalling mechanisms that influence ECM deposition and degradation during tissue remodelling and regeneration in multi-cellular culture systems have been limited. The current study investigated vascular smooth muscle cell (VSMC)-monocyte co-culture systems using different VSMC:monocyte ratios, within a degradable polyurethane scaffold, to assess their influence on ECM generation and degradation processes, and to elucidate relevant signalling molecules involved in this in vitro vascular tissue engineering system. It was found that a desired release profile of growth factors (e.g. insulin growth factor-1 (IGF-1)) and hydrolytic proteases (e.g. matrix-metalloproteinases 2, 9, 13 and 14 (MMP2, MMP9, MMP13 and MMP14)), could be achieved in co-culture systems, yielding an accumulation of ECM (specifically for 2:1 and 4:1 VSMC:monocyte culture systems). This study has significant implications for the tissue engineering field (including vascular tissue engineering), not only because it identified important cytokines and proteases that control ECM accumulation/degradation within synthetic tissue engineering scaffolds, but also because the established culture systems could be applied to improve the development of different types of tissue constructs.Sufficient extracellular matrix accumulation within cardiovascular and connective tissue engineered constructs is a prerequisite for their appropriate function in vivo. This study established co-culture systems with tissue specific cells (vascular smooth muscle cells (VSMCs)) and defined ratios of immune cells (monocytes) to investigate extracellular matrix (ECM) generation and degradation processes, revealing important mechanisms underlying ECM turnover during vascular tissue regeneration/remodelling. A specific growth factor (IGF-1), as well as hydrolytic proteases (e.g. MMP2, MMP9, MMP13 and MMP14), were identified as playing important roles in these processes. ECM accumulation was found to be dependent on achieving a desired release profile of these ECM-promoting and ECM-degrading factors within the multi-cellular microenvironment. The findings enhance our understanding of ECM deposition and degradation during in vitro tissue engineering and would be applicable to the repair or regeneration of a variety of tissues.
Author Zhang, Xiaoqing
Battiston, Kyle G.
Simmons, Craig A.
Santerre, J. Paul
Labow, Rosalind S.
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Cites_doi 10.1016/j.jvs.2007.03.001
10.2174/156652311795684740
10.1242/jcs.023820
10.1007/s40610-016-0034-6
10.1016/S0022-4804(02)00037-9
10.1007/s10439-006-9226-1
10.1083/jcb.121.3.679
10.1089/ten.2006.12.751
10.1126/science.aaf4238
10.1002/glia.21266
10.1016/j.actbio.2013.12.022
10.1002/jcp.24683
10.1016/j.carbpol.2016.07.058
10.1016/j.biomaterials.2010.09.041
10.1016/j.biomaterials.2012.08.014
10.1016/j.joca.2011.07.005
10.1016/j.biomaterials.2013.02.045
10.1016/j.imlet.2006.04.007
10.1159/000331405
10.1124/dmd.114.061317
10.1073/pnas.1017834108
10.1038/ncb2441
10.1111/j.1582-4934.2007.00031.x
10.1161/01.ATV.0000105902.89459.09
10.1016/j.addr.2014.01.013
10.1016/j.cardiores.2005.08.002
10.1089/ten.teb.2009.0527
10.1016/j.matbio.2015.05.006
10.1242/jcs.035279
10.1002/jor.22663
10.1093/gerona/gls102
10.1038/mt.2015.66
10.1016/S0945-053X(03)00052-0
10.1371/journal.pone.0039871
10.1016/j.cardiores.2006.02.021
10.1111/j.1432-0436.2007.00221.x
10.1016/j.biomaterials.2011.04.048
10.3892/ijmm.2015.2320
10.1016/j.actbio.2015.05.038
10.1161/ATVBAHA.107.157537
10.1371/journal.pone.0040951
10.1161/01.ATV.11.5.1223
10.1002/jcp.22322
10.1038/nrd3799
10.1016/j.ejcts.2008.03.062
10.1016/j.biomaterials.2014.02.023
10.1038/mi.2008.85
10.1089/ten.tea.2009.0129
10.1038/nrm3902
10.1371/journal.pone.0073279
10.1161/ATVBAHA.108.173898
10.1016/j.biomaterials.2011.09.044
10.1016/S0142-9612(00)00196-4
10.1016/j.addr.2011.01.009
10.1098/rsif.2012.0308
10.1016/j.biomaterials.2012.05.042
10.1002/1097-4636(200011)52:2<239::AID-JBM1>3.0.CO;2-R
10.1016/j.matbio.2015.01.005
10.1016/j.smim.2007.11.004
10.1186/1479-5876-12-88
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Keywords Extracellular matrix
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References Long, Tranquillo (b0030) 2003; 22
Amento, Ehsani, Palmer, Libby (b0280) 1991; 11
Muiznieks, Keeley (b0170) 1832; 2013
Meretoja, Dahlin, Kasper, Mikos (b0110) 2012; 33
Hinz (b0265) 2015; 47
Krenning, Zeisberg, Kalluri (b0120) 2010; 225
Dahl, Rhim, Song, Niklason (b0175) 2007; 35
Higashi, Sukhanov, Anwar, Shai, Delafontaine (b0200) 2012; 67
Battiston, Cheung, Jain, Santerre (b0060) 2014; 35
Yi, Noh, Lee (b0055) 2011; 11
Lehti, Rose, Valavaara, Weiss, Keski-Oja (b0250) 2009; 122
Chen, Duan, Zhu, Xiong, Wang (b0015) 2014; 12
Di Maggio, Piccinini, Jaworski, Trumpp, Wendt, Martin (b0140) 2011; 32
Zachos, Steubesand, Seekamp, Fuchs, Lippross (b0315) 2014; 32
Kirkpatrick, Fuchs, Unger (b0065) 2011; 63
Keire, L'Heureux, Vernon, Merrilees, Starcher, Okon, Dusserre, McAllister, Wight (b0045) 2010; 16
Boynton, Waddell, Meek, Labow, Edwards, Santerre (b0235) 2000; 52
Cooke, Allon, Cheng, Kuo, Kim, Vail, Marcucio, Schneider, Lotz, Alliston (b0085) 2011; 19
Tonkin, Temmerman, Sampson, Gallego-Colon, Barberi, Bilbao, Schneider, Musaro, Rosenthal (b0215) 2015; 23
Nicolaidou, Wong, Redpath, Ersek, Baban, Williams, Cope, Horwood (b0310) 2012; 7
Wakelin, Sabroe, Gregory, Poxton, Forsythe, Garden, Howie (b0050) 2006; 106
Jacobsen, Major Jourden, Miller, Cohen (b0270) 1803; 2010
Akhyari, Kamiya, Haverich, Karck, Lichtenberg (b0010) 2008; 34
Rhodes, Simons (b0020) 2007; 11
Mann, Schmedlen, West (b0025) 2001; 22
Yan, Wang, Hu, Wang, Qiao, Ma, Tang, Gu (b0275) 2015; 36
Patel, Fine, Sandig, Mequanint (b0180) 2006; 71
Neuzi, Giselbrecht, Lange, Huang, Manz (b0135) 2012; 11
Rzucidlo, Martin, Powell (b0285) 2007; 45
McBane, Sharifpoor, Cai, Labow, Santerre (b0185) 2011; 32
Mouw, Ou, Weaver (b0165) 2014; 15
Waldeck, Wang, Joyce, Kao (b0290) 2012; 33
Berg, Hsu, Lee (b0125) 2014; 69–70
Ravi, Paramesh, Kaviya, Anuradha, Solomon (b0105) 2015; 230
Van Doren (b0240) 2015; 44–46
Xu, Gao, Hao, Li, Wang, Zhang, Wang, Gao, Wang (b0130) 2013; 34
Wang, Wang, Farhangfar, Zimmer, Zhang (b0080) 2012; 7
Jones, Gockerman, Busby, Camacho-Hubner, Clemmons (b0260) 1993; 121
Morhayim, Rudjito, van Leeuwen, van Driel (b0095) 2016; 2
Mass, Ballesteros, Farlik, Halbritter, Gunther, Crozet, Jacome-Galarza, Handler, Klughammer, Kobayashi, Gomez-Perdiguero, Schultze, Beyer, Bock, Geissmann (b0070) 2016; 353
Nguyen, Ukairo, Khetani, McVay, Kanchagar, Seghezzi, Ayanoglu, Irrechukwu, Evers (b0295) 2015; 43
Zinchenko, Schrum, Clemens, Coger (b0300) 2006; 12
Battiston, Labow, Santerre (b0190) 2012; 33
Battiston, Labow, Simmons, Santerre (b0035) 2015; 24
Delafontaine, Song, Li (b0210) 2004; 24
Battiston, Ouyang, Labow, Simmons, Santerre (b0195) 2014; 10
Kubota, Okazaki, Louie, Kent, Liu (b0205) 2003; 109
Schubert, Benarroch, Ostvang, Edelman (b0075) 2008; 28
Frantz, Stewart, Weaver (b0160) 2010; 123
Hergenreider, Heydt, Treguer, Boettger, Horrevoets, Zeiher, Scheffer, Frangakis, Yin, Mayr, Braun, Urbich, Boon, Dimmeler (b0145) 2012; 14
Naito, Williams-Fritze, Duncan, Church, Hibino, Madri, Humphrey, Shinoka, Breuer (b0225) 2012; 195
Kaji, Camci-Unal, Langer, Khademhosseini (b0150) 1810; 2011
Nkyimbeng, Ruppert, Shiomi, Dahal, Lang, Seeger, Okada, D'Armiento, Gunther (b0255) 2013; 8
Anderson, Rodriguez, Chang (b0155) 2008; 20
Wilson, Wynn (b0115) 2009; 2
Song, Zhang, Lv, Guo, Lou, Wang, Wang, Yu, Ma (b0090) 2016; 153
Olah, Amor, Brouwer, Vinet, Eggen, Biber, Boddeke (b0305) 2012; 60
Dinnes, Santerre, Labow (b0230) 2008; 76
Villalona, Udelsman, Duncan, McGillicuddy, Sawh-Martinez, Hibino, Painter, Mirensky, Erickson, Shinoka, Breuer (b0005) 2010; 16
Lee, Stolz, Wang (b0040) 2011; 108
Ventre, Causa, Netti (b0100) 2012; 9
Newby (b0245) 2008; 28
Newby (b0220) 2006; 69
Newby (10.1016/j.actbio.2017.02.041_b0245) 2008; 28
Hergenreider (10.1016/j.actbio.2017.02.041_b0145) 2012; 14
Zinchenko (10.1016/j.actbio.2017.02.041_b0300) 2006; 12
Nicolaidou (10.1016/j.actbio.2017.02.041_b0310) 2012; 7
Ventre (10.1016/j.actbio.2017.02.041_b0100) 2012; 9
Olah (10.1016/j.actbio.2017.02.041_b0305) 2012; 60
Akhyari (10.1016/j.actbio.2017.02.041_b0010) 2008; 34
Rzucidlo (10.1016/j.actbio.2017.02.041_b0285) 2007; 45
Morhayim (10.1016/j.actbio.2017.02.041_b0095) 2016; 2
Rhodes (10.1016/j.actbio.2017.02.041_b0020) 2007; 11
Song (10.1016/j.actbio.2017.02.041_b0090) 2016; 153
Yi (10.1016/j.actbio.2017.02.041_b0055) 2011; 11
Cooke (10.1016/j.actbio.2017.02.041_b0085) 2011; 19
Neuzi (10.1016/j.actbio.2017.02.041_b0135) 2012; 11
Ravi (10.1016/j.actbio.2017.02.041_b0105) 2015; 230
Dinnes (10.1016/j.actbio.2017.02.041_b0230) 2008; 76
Jones (10.1016/j.actbio.2017.02.041_b0260) 1993; 121
Long (10.1016/j.actbio.2017.02.041_b0030) 2003; 22
Delafontaine (10.1016/j.actbio.2017.02.041_b0210) 2004; 24
Villalona (10.1016/j.actbio.2017.02.041_b0005) 2010; 16
Battiston (10.1016/j.actbio.2017.02.041_b0060) 2014; 35
Kaji (10.1016/j.actbio.2017.02.041_b0150) 1810; 2011
Meretoja (10.1016/j.actbio.2017.02.041_b0110) 2012; 33
Kubota (10.1016/j.actbio.2017.02.041_b0205) 2003; 109
Xu (10.1016/j.actbio.2017.02.041_b0130) 2013; 34
Newby (10.1016/j.actbio.2017.02.041_b0220) 2006; 69
Nkyimbeng (10.1016/j.actbio.2017.02.041_b0255) 2013; 8
Higashi (10.1016/j.actbio.2017.02.041_b0200) 2012; 67
Di Maggio (10.1016/j.actbio.2017.02.041_b0140) 2011; 32
Muiznieks (10.1016/j.actbio.2017.02.041_b0170) 1832; 2013
Battiston (10.1016/j.actbio.2017.02.041_b0190) 2012; 33
Naito (10.1016/j.actbio.2017.02.041_b0225) 2012; 195
Mann (10.1016/j.actbio.2017.02.041_b0025) 2001; 22
Wang (10.1016/j.actbio.2017.02.041_b0080) 2012; 7
Boynton (10.1016/j.actbio.2017.02.041_b0235) 2000; 52
Keire (10.1016/j.actbio.2017.02.041_b0045) 2010; 16
Wilson (10.1016/j.actbio.2017.02.041_b0115) 2009; 2
Frantz (10.1016/j.actbio.2017.02.041_b0160) 2010; 123
Battiston (10.1016/j.actbio.2017.02.041_b0035) 2015; 24
Anderson (10.1016/j.actbio.2017.02.041_b0155) 2008; 20
Mouw (10.1016/j.actbio.2017.02.041_b0165) 2014; 15
Nguyen (10.1016/j.actbio.2017.02.041_b0295) 2015; 43
Battiston (10.1016/j.actbio.2017.02.041_b0195) 2014; 10
Amento (10.1016/j.actbio.2017.02.041_b0280) 1991; 11
Jacobsen (10.1016/j.actbio.2017.02.041_b0270) 1803; 2010
Wakelin (10.1016/j.actbio.2017.02.041_b0050) 2006; 106
Kirkpatrick (10.1016/j.actbio.2017.02.041_b0065) 2011; 63
Waldeck (10.1016/j.actbio.2017.02.041_b0290) 2012; 33
Tonkin (10.1016/j.actbio.2017.02.041_b0215) 2015; 23
Van Doren (10.1016/j.actbio.2017.02.041_b0240) 2015; 44–46
Yan (10.1016/j.actbio.2017.02.041_b0275) 2015; 36
Lehti (10.1016/j.actbio.2017.02.041_b0250) 2009; 122
Chen (10.1016/j.actbio.2017.02.041_b0015) 2014; 12
Lee (10.1016/j.actbio.2017.02.041_b0040) 2011; 108
Hinz (10.1016/j.actbio.2017.02.041_b0265) 2015; 47
Krenning (10.1016/j.actbio.2017.02.041_b0120) 2010; 225
McBane (10.1016/j.actbio.2017.02.041_b0185) 2011; 32
Patel (10.1016/j.actbio.2017.02.041_b0180) 2006; 71
Berg (10.1016/j.actbio.2017.02.041_b0125) 2014; 69–70
Mass (10.1016/j.actbio.2017.02.041_b0070) 2016; 353
Dahl (10.1016/j.actbio.2017.02.041_b0175) 2007; 35
Schubert (10.1016/j.actbio.2017.02.041_b0075) 2008; 28
Zachos (10.1016/j.actbio.2017.02.041_b0315) 2014; 32
References_xml – volume: 14
  start-page: 249
  year: 2012
  end-page: 256
  ident: b0145
  article-title: Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Dimmeler
– volume: 153
  start-page: 652
  year: 2016
  end-page: 662
  ident: b0090
  article-title: Microfabrication of a tunable collagen/alginate-chitosan hydrogel membrane for controlling cell-cell interactions
  publication-title: Carbohydr. Polym.
  contributor:
    fullname: Ma
– volume: 9
  start-page: 2017
  year: 2012
  end-page: 2032
  ident: b0100
  article-title: Determinants of cell-material crosstalk at the interface: towards engineering of cell instructive materials
  publication-title: J. R. Soc. Interface
  contributor:
    fullname: Netti
– volume: 33
  start-page: 6362
  year: 2012
  end-page: 6369
  ident: b0110
  article-title: Enhanced chondrogenesis in co-cultures with articular chondrocytes and mesenchymal stem cells
  publication-title: Biomaterials
  contributor:
    fullname: Mikos
– volume: 36
  start-page: 1001
  year: 2015
  end-page: 1011
  ident: b0275
  article-title: Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury
  publication-title: Int. J. Mol. Med.
  contributor:
    fullname: Gu
– volume: 11
  start-page: 1223
  year: 1991
  end-page: 1230
  ident: b0280
  article-title: Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells
  publication-title: Arterioscler. Thromb.
  contributor:
    fullname: Libby
– volume: 63
  start-page: 291
  year: 2011
  end-page: 299
  ident: b0065
  article-title: Co-culture systems for vascularization–learning from nature
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Unger
– volume: 11
  start-page: 218
  year: 2011
  end-page: 228
  ident: b0055
  article-title: Current advances in retroviral gene therapy
  publication-title: Curr. Gene Ther.
  contributor:
    fullname: Lee
– volume: 12
  year: 2014
  ident: b0015
  article-title: Extracellular matrix production in vitro in cartilage tissue engineering
  publication-title: J. Transl. Med.
  contributor:
    fullname: Wang
– volume: 2
  start-page: 103
  year: 2009
  end-page: 121
  ident: b0115
  article-title: Pulmonary fibrosis: pathogenesis, etiology and regulation
  publication-title: Mucosal Immunol.
  contributor:
    fullname: Wynn
– volume: 35
  start-page: 4465
  year: 2014
  end-page: 4476
  ident: b0060
  article-title: Biomaterials in co-culture systems: towards optimizing tissue integration and cell signaling within scaffolds
  publication-title: Biomaterials
  contributor:
    fullname: Santerre
– volume: 19
  start-page: 1210
  year: 2011
  end-page: 1218
  ident: b0085
  article-title: Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Alliston
– volume: 76
  start-page: 232
  year: 2008
  end-page: 244
  ident: b0230
  article-title: Influence of biodegradable and non-biodegradable material surfaces on the differentiation of human monocyte-derived macrophages
  publication-title: Differentiation
  contributor:
    fullname: Labow
– volume: 2011
  start-page: 239
  year: 1810
  end-page: 250
  ident: b0150
  article-title: Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Khademhosseini
– volume: 22
  start-page: 339
  year: 2003
  end-page: 350
  ident: b0030
  article-title: Elastic fiber production in cardiovascular tissue-equivalents
  publication-title: Matrix Biol.
  contributor:
    fullname: Tranquillo
– volume: 225
  start-page: 631
  year: 2010
  end-page: 637
  ident: b0120
  article-title: The origin of fibroblasts and mechanism of cardiac fibrosis
  publication-title: J. Cell. Physiol.
  contributor:
    fullname: Kalluri
– volume: 122
  start-page: 126
  year: 2009
  end-page: 135
  ident: b0250
  article-title: MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing
  publication-title: J. Cell Sci.
  contributor:
    fullname: Keski-Oja
– volume: 109
  start-page: 43
  year: 2003
  end-page: 50
  ident: b0205
  article-title: TGF-beta stimulates collagen (I) in vascular smooth muscle cells via a short element in the proximal collagen promoter
  publication-title: J. Surg. Res.
  contributor:
    fullname: Liu
– volume: 28
  start-page: 97
  year: 2008
  end-page: 104
  ident: b0075
  article-title: Regulation of endothelial cell proliferation by primary monocytes
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  contributor:
    fullname: Edelman
– volume: 23
  start-page: 1189
  year: 2015
  end-page: 1200
  ident: b0215
  article-title: Monocyte/macrophage-derived IGF-1 orchestrates murine skeletal muscle regeneration and modulates autocrine polarization
  publication-title: Mol. Ther.
  contributor:
    fullname: Rosenthal
– volume: 16
  start-page: 341
  year: 2010
  end-page: 350
  ident: b0005
  article-title: Cell-seeding techniques in vascular tissue engineering
  publication-title: Tissue Eng. Part B. Rev.
  contributor:
    fullname: Breuer
– volume: 52
  start-page: 239
  year: 2000
  end-page: 245
  ident: b0235
  article-title: The effect of polyethylene particle chemistry on human monocyte-macrophage function in vitro
  publication-title: J. Biomed. Mater. Res.
  contributor:
    fullname: Santerre
– volume: 2010
  start-page: 72
  year: 1803
  end-page: 94
  ident: b0270
  article-title: To bind zinc or not to bind zinc: an examination of innovative approaches to improved metalloproteinase inhibition
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Cohen
– volume: 16
  start-page: 501
  year: 2010
  end-page: 512
  ident: b0045
  article-title: Expression of versican isoform V3 in the absence of ascorbate improves elastogenesis in engineered vascular constructs
  publication-title: Tissue Eng. Part A
  contributor:
    fullname: Wight
– volume: 24
  start-page: 435
  year: 2004
  end-page: 444
  ident: b0210
  article-title: Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  contributor:
    fullname: Li
– volume: 7
  start-page: e39871
  year: 2012
  ident: b0310
  article-title: Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation
  publication-title: PLoS ONE
  contributor:
    fullname: Horwood
– volume: 20
  start-page: 86
  year: 2008
  end-page: 100
  ident: b0155
  article-title: Foreign body reaction to biomaterials
  publication-title: Semin. Immunol.
  contributor:
    fullname: Chang
– volume: 28
  start-page: 2108
  year: 2008
  end-page: 2114
  ident: b0245
  article-title: Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  contributor:
    fullname: Newby
– volume: 67
  start-page: 626
  year: 2012
  end-page: 639
  ident: b0200
  article-title: Aging, atherosclerosis, and IGF-1
  publication-title: J. Gerontol. A: Biol. Sci. Med. Sci.
  contributor:
    fullname: Delafontaine
– volume: 69
  start-page: 614
  year: 2006
  end-page: 624
  ident: b0220
  article-title: Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates
  publication-title: Cardiovasc. Res.
  contributor:
    fullname: Newby
– volume: 108
  start-page: 2705
  year: 2011
  end-page: 2710
  ident: b0040
  article-title: Substantial expression of mature elastin in arterial constructs
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  contributor:
    fullname: Wang
– volume: 10
  start-page: 1146
  year: 2014
  end-page: 1155
  ident: b0195
  article-title: Monocyte/macrophage cytokine activity regulates vascular smooth muscle cell function within a degradable polyurethane scaffold
  publication-title: Acta Biomater.
  contributor:
    fullname: Santerre
– volume: 22
  start-page: 439
  year: 2001
  end-page: 444
  ident: b0025
  article-title: Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells
  publication-title: Biomaterials
  contributor:
    fullname: West
– volume: 121
  start-page: 679
  year: 1993
  end-page: 687
  ident: b0260
  article-title: Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I
  publication-title: J. Cell Biol.
  contributor:
    fullname: Clemmons
– volume: 353
  year: 2016
  ident: b0070
  article-title: Specification of tissue-resident macrophages during organogenesis
  publication-title: Science
  contributor:
    fullname: Geissmann
– volume: 60
  start-page: 306
  year: 2012
  end-page: 321
  ident: b0305
  article-title: Identification of a microglia phenotype supportive of remyelination
  publication-title: Glia
  contributor:
    fullname: Boddeke
– volume: 34
  start-page: 4109
  year: 2013
  end-page: 4117
  ident: b0130
  article-title: Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer
  publication-title: Biomaterials
  contributor:
    fullname: Wang
– volume: 7
  start-page: e40951
  year: 2012
  ident: b0080
  article-title: Enhanced keratinocyte proliferation and migration in co-culture with fibroblasts
  publication-title: PLoS ONE
  contributor:
    fullname: Zhang
– volume: 123
  start-page: 4195
  year: 2010
  end-page: 4200
  ident: b0160
  article-title: The extracellular matrix at a glance
  publication-title: J. Cell Sci.
  contributor:
    fullname: Weaver
– volume: 33
  start-page: 8316
  year: 2012
  end-page: 8328
  ident: b0190
  article-title: Protein binding mediation of biomaterial-dependent monocyte activation on a degradable polar hydrophobic ionic polyurethane
  publication-title: Biomaterials
  contributor:
    fullname: Santerre
– volume: 24
  start-page: 74
  year: 2015
  end-page: 86
  ident: b0035
  article-title: Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation
  publication-title: Acta Biomater.
  contributor:
    fullname: Santerre
– volume: 47
  start-page: 54
  year: 2015
  end-page: 65
  ident: b0265
  article-title: The extracellular matrix and transforming growth factor-beta1: tale of a strained relationship
  publication-title: Matrix Biol.
  contributor:
    fullname: Hinz
– volume: 44–46
  start-page: 224
  year: 2015
  end-page: 231
  ident: b0240
  article-title: Matrix metalloproteinase interactions with collagen and elastin
  publication-title: Matrix Biol.
  contributor:
    fullname: Van Doren
– volume: 8
  start-page: e73279
  year: 2013
  ident: b0255
  article-title: Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis
  publication-title: PLoS ONE
  contributor:
    fullname: Gunther
– volume: 34
  start-page: 229
  year: 2008
  end-page: 241
  ident: b0010
  article-title: Myocardial tissue engineering: the extracellular matrix
  publication-title: Eur. J. Cardiothorac. Surg.
  contributor:
    fullname: Lichtenberg
– volume: 230
  start-page: 16
  year: 2015
  end-page: 26
  ident: b0105
  article-title: 3D cell culture systems: advantages and applications
  publication-title: J. Cell. Physiol.
  contributor:
    fullname: Solomon
– volume: 33
  start-page: 29
  year: 2012
  end-page: 37
  ident: b0290
  article-title: Active leukocyte detachment and apoptosis/necrosis on PEG hydrogels and the implication in the host inflammatory response
  publication-title: Biomaterials
  contributor:
    fullname: Kao
– volume: 11
  start-page: 176
  year: 2007
  end-page: 205
  ident: b0020
  article-title: The extracellular matrix and blood vessel formation: not just a scaffold
  publication-title: J. Cell Mol. Med.
  contributor:
    fullname: Simons
– volume: 35
  start-page: 348
  year: 2007
  end-page: 355
  ident: b0175
  article-title: Mechanical properties and compositions of tissue engineered and native arteries
  publication-title: Ann. Biomed. Eng.
  contributor:
    fullname: Niklason
– volume: 106
  start-page: 1
  year: 2006
  end-page: 7
  ident: b0050
  article-title: “Dirty little secrets”–endotoxin contamination of recombinant proteins
  publication-title: Immunol. Lett.
  contributor:
    fullname: Howie
– volume: 32
  start-page: 1264
  year: 2014
  end-page: 1270
  ident: b0315
  article-title: Co-cultures of programmable cells of monocytic origin and mesenchymal stem cells do increase osteogenic differentiation
  publication-title: J. Orthop. Res.
  contributor:
    fullname: Lippross
– volume: 2
  start-page: 48
  year: 2016
  end-page: 55
  ident: b0095
  article-title: Paracrine signaling by extracellular vesicles via osteoblasts
  publication-title: Curr. Mol. Biol. Rep.
  contributor:
    fullname: van Driel
– volume: 69–70
  start-page: 190
  year: 2014
  end-page: 204
  ident: b0125
  article-title: Consideration of the cellular microenvironment: physiologically relevant co-culture systems in drug discovery
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Lee
– volume: 15
  start-page: 771
  year: 2014
  end-page: 785
  ident: b0165
  article-title: Extracellular matrix assembly: a multiscale deconstruction
  publication-title: Nat. Rev. Mol. Cell Biol.
  contributor:
    fullname: Weaver
– volume: 43
  start-page: 774
  year: 2015
  end-page: 785
  ident: b0295
  article-title: Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters
  publication-title: Drug Metab. Dispos.
  contributor:
    fullname: Evers
– volume: 12
  start-page: 751
  year: 2006
  end-page: 761
  ident: b0300
  article-title: Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function
  publication-title: Tissue Eng.
  contributor:
    fullname: Coger
– volume: 11
  start-page: 620
  year: 2012
  end-page: 632
  ident: b0135
  article-title: Revisiting lab-on-a-chip technology for drug discovery
  publication-title: Nat. Rev. Drug Discov.
  contributor:
    fullname: Manz
– volume: 71
  start-page: 40
  year: 2006
  end-page: 49
  ident: b0180
  article-title: Elastin biosynthesis: the missing link in tissue-engineered blood vessels
  publication-title: Cardiovasc. Res.
  contributor:
    fullname: Mequanint
– volume: 45
  start-page: A25
  year: 2007
  end-page: A32
  ident: b0285
  article-title: Regulation of vascular smooth muscle cell differentiation
  publication-title: J. Vasc. Surg.
  contributor:
    fullname: Powell
– volume: 32
  start-page: 6034
  year: 2011
  end-page: 6044
  ident: b0185
  article-title: Biodegradation and in vivo biocompatibility of a degradable, polar/hydrophobic/ionic polyurethane for tissue engineering applications
  publication-title: Biomaterials
  contributor:
    fullname: Santerre
– volume: 32
  start-page: 321
  year: 2011
  end-page: 329
  ident: b0140
  article-title: Toward modeling the bone marrow niche using scaffold-based 3D culture systems
  publication-title: Biomaterials
  contributor:
    fullname: Martin
– volume: 2013
  start-page: 866
  year: 1832
  end-page: 875
  ident: b0170
  article-title: Molecular assembly and mechanical properties of the extracellular matrix: a fibrous protein perspective
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Keeley
– volume: 195
  start-page: 60
  year: 2012
  end-page: 72
  ident: b0225
  article-title: Characterization of the natural history of extracellular matrix production in tissue-engineered vascular grafts during neovessel formation
  publication-title: Cells Tissues Organs
  contributor:
    fullname: Breuer
– volume: 45
  start-page: A25
  issue: Suppl. A
  year: 2007
  ident: 10.1016/j.actbio.2017.02.041_b0285
  article-title: Regulation of vascular smooth muscle cell differentiation
  publication-title: J. Vasc. Surg.
  doi: 10.1016/j.jvs.2007.03.001
  contributor:
    fullname: Rzucidlo
– volume: 11
  start-page: 218
  year: 2011
  ident: 10.1016/j.actbio.2017.02.041_b0055
  article-title: Current advances in retroviral gene therapy
  publication-title: Curr. Gene Ther.
  doi: 10.2174/156652311795684740
  contributor:
    fullname: Yi
– volume: 123
  start-page: 4195
  year: 2010
  ident: 10.1016/j.actbio.2017.02.041_b0160
  article-title: The extracellular matrix at a glance
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.023820
  contributor:
    fullname: Frantz
– volume: 2
  start-page: 48
  year: 2016
  ident: 10.1016/j.actbio.2017.02.041_b0095
  article-title: Paracrine signaling by extracellular vesicles via osteoblasts
  publication-title: Curr. Mol. Biol. Rep.
  doi: 10.1007/s40610-016-0034-6
  contributor:
    fullname: Morhayim
– volume: 109
  start-page: 43
  year: 2003
  ident: 10.1016/j.actbio.2017.02.041_b0205
  article-title: TGF-beta stimulates collagen (I) in vascular smooth muscle cells via a short element in the proximal collagen promoter
  publication-title: J. Surg. Res.
  doi: 10.1016/S0022-4804(02)00037-9
  contributor:
    fullname: Kubota
– volume: 35
  start-page: 348
  year: 2007
  ident: 10.1016/j.actbio.2017.02.041_b0175
  article-title: Mechanical properties and compositions of tissue engineered and native arteries
  publication-title: Ann. Biomed. Eng.
  doi: 10.1007/s10439-006-9226-1
  contributor:
    fullname: Dahl
– volume: 121
  start-page: 679
  year: 1993
  ident: 10.1016/j.actbio.2017.02.041_b0260
  article-title: Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.121.3.679
  contributor:
    fullname: Jones
– volume: 12
  start-page: 751
  year: 2006
  ident: 10.1016/j.actbio.2017.02.041_b0300
  article-title: Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function
  publication-title: Tissue Eng.
  doi: 10.1089/ten.2006.12.751
  contributor:
    fullname: Zinchenko
– volume: 353
  year: 2016
  ident: 10.1016/j.actbio.2017.02.041_b0070
  article-title: Specification of tissue-resident macrophages during organogenesis
  publication-title: Science
  doi: 10.1126/science.aaf4238
  contributor:
    fullname: Mass
– volume: 60
  start-page: 306
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0305
  article-title: Identification of a microglia phenotype supportive of remyelination
  publication-title: Glia
  doi: 10.1002/glia.21266
  contributor:
    fullname: Olah
– volume: 10
  start-page: 1146
  year: 2014
  ident: 10.1016/j.actbio.2017.02.041_b0195
  article-title: Monocyte/macrophage cytokine activity regulates vascular smooth muscle cell function within a degradable polyurethane scaffold
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2013.12.022
  contributor:
    fullname: Battiston
– volume: 2010
  start-page: 72
  year: 1803
  ident: 10.1016/j.actbio.2017.02.041_b0270
  article-title: To bind zinc or not to bind zinc: an examination of innovative approaches to improved metalloproteinase inhibition
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Jacobsen
– volume: 230
  start-page: 16
  year: 2015
  ident: 10.1016/j.actbio.2017.02.041_b0105
  article-title: 3D cell culture systems: advantages and applications
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.24683
  contributor:
    fullname: Ravi
– volume: 153
  start-page: 652
  year: 2016
  ident: 10.1016/j.actbio.2017.02.041_b0090
  article-title: Microfabrication of a tunable collagen/alginate-chitosan hydrogel membrane for controlling cell-cell interactions
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2016.07.058
  contributor:
    fullname: Song
– volume: 32
  start-page: 321
  year: 2011
  ident: 10.1016/j.actbio.2017.02.041_b0140
  article-title: Toward modeling the bone marrow niche using scaffold-based 3D culture systems
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2010.09.041
  contributor:
    fullname: Di Maggio
– volume: 33
  start-page: 8316
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0190
  article-title: Protein binding mediation of biomaterial-dependent monocyte activation on a degradable polar hydrophobic ionic polyurethane
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2012.08.014
  contributor:
    fullname: Battiston
– volume: 19
  start-page: 1210
  year: 2011
  ident: 10.1016/j.actbio.2017.02.041_b0085
  article-title: Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2011.07.005
  contributor:
    fullname: Cooke
– volume: 34
  start-page: 4109
  year: 2013
  ident: 10.1016/j.actbio.2017.02.041_b0130
  article-title: Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.02.045
  contributor:
    fullname: Xu
– volume: 106
  start-page: 1
  year: 2006
  ident: 10.1016/j.actbio.2017.02.041_b0050
  article-title: “Dirty little secrets”–endotoxin contamination of recombinant proteins
  publication-title: Immunol. Lett.
  doi: 10.1016/j.imlet.2006.04.007
  contributor:
    fullname: Wakelin
– volume: 195
  start-page: 60
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0225
  article-title: Characterization of the natural history of extracellular matrix production in tissue-engineered vascular grafts during neovessel formation
  publication-title: Cells Tissues Organs
  doi: 10.1159/000331405
  contributor:
    fullname: Naito
– volume: 43
  start-page: 774
  year: 2015
  ident: 10.1016/j.actbio.2017.02.041_b0295
  article-title: Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.114.061317
  contributor:
    fullname: Nguyen
– volume: 108
  start-page: 2705
  year: 2011
  ident: 10.1016/j.actbio.2017.02.041_b0040
  article-title: Substantial expression of mature elastin in arterial constructs
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.1017834108
  contributor:
    fullname: Lee
– volume: 14
  start-page: 249
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0145
  article-title: Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2441
  contributor:
    fullname: Hergenreider
– volume: 11
  start-page: 176
  year: 2007
  ident: 10.1016/j.actbio.2017.02.041_b0020
  article-title: The extracellular matrix and blood vessel formation: not just a scaffold
  publication-title: J. Cell Mol. Med.
  doi: 10.1111/j.1582-4934.2007.00031.x
  contributor:
    fullname: Rhodes
– volume: 24
  start-page: 435
  year: 2004
  ident: 10.1016/j.actbio.2017.02.041_b0210
  article-title: Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/01.ATV.0000105902.89459.09
  contributor:
    fullname: Delafontaine
– volume: 69–70
  start-page: 190
  year: 2014
  ident: 10.1016/j.actbio.2017.02.041_b0125
  article-title: Consideration of the cellular microenvironment: physiologically relevant co-culture systems in drug discovery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2014.01.013
  contributor:
    fullname: Berg
– volume: 69
  start-page: 614
  year: 2006
  ident: 10.1016/j.actbio.2017.02.041_b0220
  article-title: Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates
  publication-title: Cardiovasc. Res.
  doi: 10.1016/j.cardiores.2005.08.002
  contributor:
    fullname: Newby
– volume: 16
  start-page: 341
  year: 2010
  ident: 10.1016/j.actbio.2017.02.041_b0005
  article-title: Cell-seeding techniques in vascular tissue engineering
  publication-title: Tissue Eng. Part B. Rev.
  doi: 10.1089/ten.teb.2009.0527
  contributor:
    fullname: Villalona
– volume: 2013
  start-page: 866
  year: 1832
  ident: 10.1016/j.actbio.2017.02.041_b0170
  article-title: Molecular assembly and mechanical properties of the extracellular matrix: a fibrous protein perspective
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Muiznieks
– volume: 47
  start-page: 54
  year: 2015
  ident: 10.1016/j.actbio.2017.02.041_b0265
  article-title: The extracellular matrix and transforming growth factor-beta1: tale of a strained relationship
  publication-title: Matrix Biol.
  doi: 10.1016/j.matbio.2015.05.006
  contributor:
    fullname: Hinz
– volume: 122
  start-page: 126
  year: 2009
  ident: 10.1016/j.actbio.2017.02.041_b0250
  article-title: MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.035279
  contributor:
    fullname: Lehti
– volume: 32
  start-page: 1264
  year: 2014
  ident: 10.1016/j.actbio.2017.02.041_b0315
  article-title: Co-cultures of programmable cells of monocytic origin and mesenchymal stem cells do increase osteogenic differentiation
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.22663
  contributor:
    fullname: Zachos
– volume: 67
  start-page: 626
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0200
  article-title: Aging, atherosclerosis, and IGF-1
  publication-title: J. Gerontol. A: Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/gls102
  contributor:
    fullname: Higashi
– volume: 23
  start-page: 1189
  year: 2015
  ident: 10.1016/j.actbio.2017.02.041_b0215
  article-title: Monocyte/macrophage-derived IGF-1 orchestrates murine skeletal muscle regeneration and modulates autocrine polarization
  publication-title: Mol. Ther.
  doi: 10.1038/mt.2015.66
  contributor:
    fullname: Tonkin
– volume: 2011
  start-page: 239
  year: 1810
  ident: 10.1016/j.actbio.2017.02.041_b0150
  article-title: Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Kaji
– volume: 22
  start-page: 339
  year: 2003
  ident: 10.1016/j.actbio.2017.02.041_b0030
  article-title: Elastic fiber production in cardiovascular tissue-equivalents
  publication-title: Matrix Biol.
  doi: 10.1016/S0945-053X(03)00052-0
  contributor:
    fullname: Long
– volume: 7
  start-page: e39871
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0310
  article-title: Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0039871
  contributor:
    fullname: Nicolaidou
– volume: 71
  start-page: 40
  year: 2006
  ident: 10.1016/j.actbio.2017.02.041_b0180
  article-title: Elastin biosynthesis: the missing link in tissue-engineered blood vessels
  publication-title: Cardiovasc. Res.
  doi: 10.1016/j.cardiores.2006.02.021
  contributor:
    fullname: Patel
– volume: 76
  start-page: 232
  year: 2008
  ident: 10.1016/j.actbio.2017.02.041_b0230
  article-title: Influence of biodegradable and non-biodegradable material surfaces on the differentiation of human monocyte-derived macrophages
  publication-title: Differentiation
  doi: 10.1111/j.1432-0436.2007.00221.x
  contributor:
    fullname: Dinnes
– volume: 32
  start-page: 6034
  year: 2011
  ident: 10.1016/j.actbio.2017.02.041_b0185
  article-title: Biodegradation and in vivo biocompatibility of a degradable, polar/hydrophobic/ionic polyurethane for tissue engineering applications
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2011.04.048
  contributor:
    fullname: McBane
– volume: 36
  start-page: 1001
  year: 2015
  ident: 10.1016/j.actbio.2017.02.041_b0275
  article-title: Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury
  publication-title: Int. J. Mol. Med.
  doi: 10.3892/ijmm.2015.2320
  contributor:
    fullname: Yan
– volume: 24
  start-page: 74
  year: 2015
  ident: 10.1016/j.actbio.2017.02.041_b0035
  article-title: Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2015.05.038
  contributor:
    fullname: Battiston
– volume: 28
  start-page: 97
  year: 2008
  ident: 10.1016/j.actbio.2017.02.041_b0075
  article-title: Regulation of endothelial cell proliferation by primary monocytes
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.107.157537
  contributor:
    fullname: Schubert
– volume: 7
  start-page: e40951
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0080
  article-title: Enhanced keratinocyte proliferation and migration in co-culture with fibroblasts
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0040951
  contributor:
    fullname: Wang
– volume: 11
  start-page: 1223
  year: 1991
  ident: 10.1016/j.actbio.2017.02.041_b0280
  article-title: Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells
  publication-title: Arterioscler. Thromb.
  doi: 10.1161/01.ATV.11.5.1223
  contributor:
    fullname: Amento
– volume: 225
  start-page: 631
  year: 2010
  ident: 10.1016/j.actbio.2017.02.041_b0120
  article-title: The origin of fibroblasts and mechanism of cardiac fibrosis
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.22322
  contributor:
    fullname: Krenning
– volume: 11
  start-page: 620
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0135
  article-title: Revisiting lab-on-a-chip technology for drug discovery
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd3799
  contributor:
    fullname: Neuzi
– volume: 34
  start-page: 229
  year: 2008
  ident: 10.1016/j.actbio.2017.02.041_b0010
  article-title: Myocardial tissue engineering: the extracellular matrix
  publication-title: Eur. J. Cardiothorac. Surg.
  doi: 10.1016/j.ejcts.2008.03.062
  contributor:
    fullname: Akhyari
– volume: 35
  start-page: 4465
  year: 2014
  ident: 10.1016/j.actbio.2017.02.041_b0060
  article-title: Biomaterials in co-culture systems: towards optimizing tissue integration and cell signaling within scaffolds
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2014.02.023
  contributor:
    fullname: Battiston
– volume: 2
  start-page: 103
  year: 2009
  ident: 10.1016/j.actbio.2017.02.041_b0115
  article-title: Pulmonary fibrosis: pathogenesis, etiology and regulation
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2008.85
  contributor:
    fullname: Wilson
– volume: 16
  start-page: 501
  year: 2010
  ident: 10.1016/j.actbio.2017.02.041_b0045
  article-title: Expression of versican isoform V3 in the absence of ascorbate improves elastogenesis in engineered vascular constructs
  publication-title: Tissue Eng. Part A
  doi: 10.1089/ten.tea.2009.0129
  contributor:
    fullname: Keire
– volume: 15
  start-page: 771
  year: 2014
  ident: 10.1016/j.actbio.2017.02.041_b0165
  article-title: Extracellular matrix assembly: a multiscale deconstruction
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3902
  contributor:
    fullname: Mouw
– volume: 8
  start-page: e73279
  year: 2013
  ident: 10.1016/j.actbio.2017.02.041_b0255
  article-title: Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0073279
  contributor:
    fullname: Nkyimbeng
– volume: 28
  start-page: 2108
  year: 2008
  ident: 10.1016/j.actbio.2017.02.041_b0245
  article-title: Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.108.173898
  contributor:
    fullname: Newby
– volume: 33
  start-page: 29
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0290
  article-title: Active leukocyte detachment and apoptosis/necrosis on PEG hydrogels and the implication in the host inflammatory response
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2011.09.044
  contributor:
    fullname: Waldeck
– volume: 22
  start-page: 439
  year: 2001
  ident: 10.1016/j.actbio.2017.02.041_b0025
  article-title: Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(00)00196-4
  contributor:
    fullname: Mann
– volume: 63
  start-page: 291
  year: 2011
  ident: 10.1016/j.actbio.2017.02.041_b0065
  article-title: Co-culture systems for vascularization–learning from nature
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2011.01.009
  contributor:
    fullname: Kirkpatrick
– volume: 9
  start-page: 2017
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0100
  article-title: Determinants of cell-material crosstalk at the interface: towards engineering of cell instructive materials
  publication-title: J. R. Soc. Interface
  doi: 10.1098/rsif.2012.0308
  contributor:
    fullname: Ventre
– volume: 33
  start-page: 6362
  year: 2012
  ident: 10.1016/j.actbio.2017.02.041_b0110
  article-title: Enhanced chondrogenesis in co-cultures with articular chondrocytes and mesenchymal stem cells
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2012.05.042
  contributor:
    fullname: Meretoja
– volume: 52
  start-page: 239
  year: 2000
  ident: 10.1016/j.actbio.2017.02.041_b0235
  article-title: The effect of polyethylene particle chemistry on human monocyte-macrophage function in vitro
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/1097-4636(200011)52:2<239::AID-JBM1>3.0.CO;2-R
  contributor:
    fullname: Boynton
– volume: 44–46
  start-page: 224
  year: 2015
  ident: 10.1016/j.actbio.2017.02.041_b0240
  article-title: Matrix metalloproteinase interactions with collagen and elastin
  publication-title: Matrix Biol.
  doi: 10.1016/j.matbio.2015.01.005
  contributor:
    fullname: Van Doren
– volume: 20
  start-page: 86
  year: 2008
  ident: 10.1016/j.actbio.2017.02.041_b0155
  article-title: Foreign body reaction to biomaterials
  publication-title: Semin. Immunol.
  doi: 10.1016/j.smim.2007.11.004
  contributor:
    fullname: Anderson
– volume: 12
  year: 2014
  ident: 10.1016/j.actbio.2017.02.041_b0015
  article-title: Extracellular matrix production in vitro in cartilage tissue engineering
  publication-title: J. Transl. Med.
  doi: 10.1186/1479-5876-12-88
  contributor:
    fullname: Chen
SSID ssj0038128
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Snippet [Display omitted] Tissue engineering (particularly for the case of load-bearing cardiovascular and connective tissues) requires the ability to promote the...
Tissue engineering (particularly for the case of load-bearing cardiovascular and connective tissues) requires the ability to promote the production and...
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StartPage 81
SubjectTerms Accumulation
Bioaccumulation
Biomaterial
Cell culture
Co-culture
Coculture Techniques
Collagen
Collagenase 3
Collagenases - secretion
Connective tissues
Construction engineering
Cytokines
Cytokines - secretion
Degradation
Deposition
Elastin
Electrochemical machining
Extracellular matrix
Extracellular Matrix - chemistry
Gelatinase A
Gelatinase B
Growth factors
Humans
Immune system
In vitro methods and tests
In vivo methods and tests
Insulin
Insulin-like growth factor I
Matrix metalloproteinase
Monocytes
Monocytes - cytology
Monocytes - secretion
Muscle, Smooth, Vascular - cytology
Muscle, Smooth, Vascular - secretion
Myocytes, Smooth Muscle - cytology
Myocytes, Smooth Muscle - secretion
Polyurethane
Polyurethane resins
Protease
Proteinase
Regeneration
Scaffolds
Signaling
Smooth muscle
Studies
Tissue culture
Tissue Engineering
Underlying mechanisms
Vascular tissue
Title Generating favorable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment
URI https://dx.doi.org/10.1016/j.actbio.2017.02.041
https://www.ncbi.nlm.nih.gov/pubmed/28242454
https://www.proquest.com/docview/1916143773
https://search.proquest.com/docview/1872870788
Volume 54
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