E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis

• Published in: Cellular & molecular immunology Vol. 15; no. 12; pp. 1057 - 1070
• Main Authors: Chong, Zhenlu, Bao, Chunjing, He, Jia, Chen, Tianxiao, Zhong, Lijia, Li, Gaopeng, Li, Huanle, Fang, Lutong, Song, Yinjing, Fu, Guoxiang, Yang, Xuyan, Lai, Lihua, Liu, Yang, Wang, Qingqing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2018; Nature Publishing Group
• Subjects: Antibodies; Apoptosis; Autoantibodies; Autoimmune diseases; Biomedical and Life Sciences; Biomedicine; Cancer; CD11b antigen; Cdc4 protein; Cell proliferation; Glomerulonephritis; Hemorrhage; Immunology; Inflammation; Kidneys; Lupus; Lymphocytes B; Major histocompatibility complex; Mcl-1 protein; Medical Microbiology; Microbiology; Monocytes; Myeloid cells; Pathogenesis; Peritoneum; Systemic lupus erythematosus; Tumor suppressor genes; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination; Vaccine; apoptosis; Systemic lupus erythematosus; ubiquitination; MCL1; FBXW7

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, and the pathogenesis of SLE has not been fully elucidated. The E3 ubiquitin ligase FBXW7 has been well characterized in cancer as a tumor suppressor that can promote the ubiquitination and subsequent degradation of various oncoprot...