The influence of glutamatergic antagonism on motor variability, and comparison to findings in schizophrenia patients

• Published in: Acta neuropsychiatrica Vol. 25; no. 2; pp. 105 - 112
• Main Authors: Johnsen, Erik, Fasmer, Ole Bernt, van Wageningen, Heidi, Hugdahl, Kenneth, Hauge, Erik, Jørgensen, Hugo A.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.04.2013
• Subjects: Alzheimer's disease; Antipsychotics; Drug dosages; Entropy; Human subjects; Medical research; Original Articles; Physiology; Psychiatrists; Psychotropic drugs; Sample variance; Schizophrenia; Time series; glutamate antagonists; schizophrenia; motor activity

The primary aim of this explorative study was to investigate the influence of the glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist memantine on motor activity in healthy subjects. Secondarily, we wanted to compare these data to findings in a sample of schizophrenia patients. The healthy...