Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection

• Published in: Cell death & disease Vol. 11; no. 3; p. 196
• Main Authors: Dang, Xindi, Ogbu, Stella C, Zhao, Juan, Nguyen, Lam Ngoc Thao, Cao, Dechao, Nguyen, Lam Nhat, Khanal, Sushant, Schank, Madison, Thakuri, Bal Krishna Chand, Wu, Xiao Y, Morrison, Zheng D, Zhang, Jinyu, Li, Zhengke, El Gazzar, Mohamed, Ning, Shunbin, Wang, Ling, Wang, Zhengqiang, Moorman, Jonathan P, Yao, Zhi Q
• Format: Journal Article
• Language: English
• Published: England Springer Nature B.V 19.03.2020; Nature Publishing Group UK
• Subjects: Adult; Aged; Apoptosis; Apoptosis - drug effects; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - enzymology; CD4-Positive T-Lymphocytes - immunology; Cell death; Chronic Disease; Chronic infection; Deoxyribonucleic acid; Diketopiperazines; DNA; DNA biosynthesis; DNA Damage; DNA Repair; DNA topoisomerase (ATP-hydrolysing); DNA Topoisomerases, Type II - biosynthesis; DNA Topoisomerases, Type II - metabolism; DNA-Binding Proteins - antagonists & inhibitors; DNA-Binding Proteins - metabolism; Enzymatic activity; Etoposide; Etoposide - pharmacology; Female; Genomics; HIV; Human immunodeficiency virus; Humans; Infections; Lymphocytes; Lymphocytes T; Male; Middle Aged; Phosphodiesterase; Phosphoric Diester Hydrolases - metabolism; Piperazines - pharmacology; Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors; Poly (ADP-Ribose) Polymerase-1 - metabolism; Telomerase - antagonists & inhibitors; Telomerase - metabolism; Telomere - drug effects; Telomere - enzymology; Telomere - genetics; Telomeric Repeat Binding Protein 2 - metabolism; Topoisomerase II Inhibitors - pharmacology; Viral infections; Virus Diseases - enzymology; Virus Diseases - genetics; Virus Diseases - immunology; Young Adult

T cells play a critical role in controlling viral infection; however, the mechanisms regulating their responses remain incompletely understood. Here, we investigated the role of topoisomerase IIA (Top2α, an enzyme that is essential in resolving entangled DNA strands during replication) in telomeric...