Claudin-1 contributes to the epithelial barrier function in MDCK cells

• Published in: European journal of cell biology Vol. 78; no. 12; pp. 849 - 855
• Main Authors: Inai, Tetsuichiro, Kobayashi, Junichi, Shibata, Yosaburo
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.12.1999
• Subjects: Animals; Biological Transport; Cell Communication - physiology; Cell Line; Cell Membrane Permeability - physiology; Claudin-1; Dogs; epithelial barrier; Epithelial Cells - physiology; Epithelial Cells - ultrastructure; Membrane Proteins - physiology; Mice; occludin; tight junction; Tight Junctions - physiology; ZO-1; occludin; ZO-1; epithelial barrier; Claudin-1; tight junction

Tight junctions (TJs) create a paracellular permeability barrier and also act as a fence preventing intermixing of proteins and lipids between the apical and basolateral plasma membranes. Recently, claudin-1 has been identified as an integral membrane protein localizing at TJs, and introduced claudi...